Disease modifying biomaterials for modulating mechanical allodynia in a preclinical model of rheumatoid arthritis [0.03%]
用于调节类风湿关节炎临床前模型机械痛觉过敏的疾病修饰生物材料
Maksim Dolmat,Julia Borges Paes Lemes,Wade T Johnson et al.
Maksim Dolmat et al.
Pain is a key symptom associated with rheumatoid arthritis (RA) and can persist even in the context of overall disease control by standard-of-care disease modifying anti-rheumatic drugs (DMARDs). Analgesic agents and corticosteroids are oft...
Decellularized lymph node scaffolds accelerate restoration of lymphatic drainage in rat hind limb lymphedema [0.03%]
脱细胞淋巴结支架加速大鼠后肢淋巴水肿的淋巴回流恢复
Yang Jian,Jian Zhou,Wenjie Pan et al.
Yang Jian et al.
Background: There is a lack of effective lymphedema prevention methods. The objective of this study was to investigate the ability of decellularized lymph nodes (dLNs) transplantation to prevent hindlimb lymphedema. ...
Engineered probiotic ameliorates hyperlipidemia and atherosclerosis by secreting PCSK9 nanobodies and regulating gut microbiota [0.03%]
一种工程益生菌通过分泌PCSK9纳米抗体和调节肠道微生物群来改善高脂血症和动脉粥样硬化
Chuan Wang,Junyue Xing,Huan Zhao et al.
Chuan Wang et al.
Elevated levels of low-density lipoprotein cholesterol (LDL-C) play a critical role in the onset and progression of cardiovascular disease (CVD). Inhibitors or monoclonal antibody drugs targeting pro-protein convertase subtilisin/kexin type...
Advances in biosensors for diagnosis and monitoring of inflammatory bowel disease: A review [0.03%]
炎症性肠病诊断和监测的生物传感器进展：综述
Wenyu Fu,Ruier Xue,Mohit N Shivdasani et al.
Wenyu Fu et al.
Inflammatory bowel disease (IBD) encompasses a group of intestinal disorders, primarily Crohn's disease (CD) and ulcerative colitis (UC), characterized by chronic inflammation of the digestive tract. Despite extensive research, the etiology...
Enhanced Schwann cell differentiation of skin-derived neural crest-like stem cells through the synergistic action of SOX10 and immobilized NRG1 signaling [0.03%]
通过SOX10和固定化NRG1信号的协同作用增强皮肤源性神经嵴样干细胞向施万细胞分化
Ashis Kumar Podder,Pihu Mehrotra,Pedro Lei et al.
Ashis Kumar Podder et al.
Human skin-derived neural crest (NC)-like stem cells present a highly accessible, autologous source of multipotent cells, with the potential to differentiate into a variety of cell types, including Schwann cells (SCs). However, these cells ...
A digital ELISA for multiplexed detection of allergen-specific IgE against Der p 1, Der p 2, and Der p 23 [0.03%]
一种数字化ELISA技术以实现Der p 1、Der p 2和Der p 23特异性IgE的多重检测
Feifei Han,Shih-Mo Yang,Ju Xue et al.
Feifei Han et al.
The house dust mite Dermatophagoides pteronyssinus produces major allergens (Der p 1, Der p 2, and Der p 23) that require precise IgE detection for clinical diagnosis. We developed a multiplex digital ELISA using fluorescence-encoded microm...
Ex vivo single-cell profiling of acute myocardial infarction patients reveals disproportionate CD66b+ cell secretion response [0.03%]
急性心肌梗死患者的体外单细胞转录组分析揭示了CD66b+细胞的分泌反应失调
Kerwin Kwek Zeming,Ri Lu,Elizabeth Lee et al.
Kerwin Kwek Zeming et al.
Acute myocardial infarction (AMI), a leading cause of death globally, triggers complex inflammatory responses critical to patient outcomes. However, rapid tools for profiling immune responses at the single-cell level are lacking. The integr...
3D printed nerve guidance conduit for biologics-free nerve regeneration and vascular integration [0.03%]
一种用于生物制品自由的神经再生和血管整合的3D打印神经导管
Jacob Schimelman,David B Berry,Susie Johnson et al.
Jacob Schimelman et al.
There is a clinical need for an effective nerve guidance conduit to treat peripheral nerve injuries. Many studies have explored different materials and active cues to guide neural regeneration, with some success. However, none have demonstr...
Dante Disharoon,Sonali Rohiwal,Selvin Hernandez et al.
Dante Disharoon et al.
Blood is a liquid connective tissue containing cellular and non-cellular components. Blood circulation is vital to life since it transports gases and nutrients, maintains immune surveillance, promotes necessary clotting to prevent hemorrhag...
Near Infrared-light responsive chlorin e6 pro-drug micellar photodynamic therapy for oral cancer [0.03%]
用于口腔癌治疗的近红外光响应氯化e6前药micellar光动力疗法
Milan Paul,Swati Biswas
Milan Paul
A major concern of conventional photodynamic therapy is its non-specific toxicity due to off-site drug accumulation. Micelles tend to localize the drug to the tumor site. However, rapid drug release at high concentrations from the micelles ...