Site-specific noninvasive delivery of retrograde viral vectors to the brain [0.03%]
定点非侵入性地将逆行病毒载体递送至大脑
Manwal Harb,Shirin Nouraein,Jerzy O Szablowski
Manwal Harb
Neuronal activity underlies the brain function. Different behaviors, physiological processes, and disorders depend on which neurons are active at a given moment. Treating brain disorders without side effects will require exclusive control o...
Three-dimensional modeling of flow through microvascular beds and surrounding interstitial spaces [0.03%]
微血管床及其周围间质空间内的三维流体模型
Navaneeth Krishna Rajeeva Pandian,Alanna Farrell,Emily Davis et al.
Navaneeth Krishna Rajeeva Pandian et al.
The health and function of microvascular beds are dramatically impacted by the mechanical forces that they experience due to fluid flow. These fluid flow-generated forces are challenging to measure directly and are typically calculated from...
Renal-targeted exosomes inhibiting miR-182-5p for treatment of renal ischemia-reperfusion injury [0.03%]
肾脏靶向性外泌体抑制miR-182-5p治疗肾缺血再灌注损伤
Zepeng Li,Shirui Sun,Zhenting Zhao et al.
Zepeng Li et al.
Renal ischemia-reperfusion injury (IRI) is a significant condition that leads to acute kidney injury, exacerbating the progression of renal failure clinically and affecting the patient's prognosis. Following the identification of miR-182-5p...
Engineered endothelial cells targeting and dihydrotanshinone I loaded bacterial extracellular vesicles for atherosclerosis therapy [0.03%]
工程化内皮细胞递送和载有菌体外囊泡丹参素I用于动脉粥样硬化治疗
Rong-Rong Zhu,Xue-Liang Zhou,Yan-Wei Liu et al.
Rong-Rong Zhu et al.
Atherosclerosis (AS) is a complex cardiovascular disease characterized by endothelial dysfunction, dyslipidemia, and immune-inflammatory responses, leading to arterial plaque formation and potentially fatal complications such as myocardial ...
Advanced hydrogel therapeutics for intervertebral disc degeneration: Engineering structural-functional properties in natural and synthetic biomaterials [0.03%]
用于椎间盘退变的先进水凝胶治疗：天然和合成生物材料的结构-功能属性工程学
Tao Chen,Dading Lu,Siqiao Wang et al.
Tao Chen et al.
Low back pain is a global health challenge, imposing substantial socioeconomic burdens. Intervertebral disc degeneration (IVDD) is a leading cause of low back pain and can lead to further spinal complications. Current treatments for IVDD ar...
Design and pharmacodynamic study of live biotherapeutic products with efficient degradation of branched-chain amino acids [0.03%]
高效的支链氨基酸降解型活体生物治疗产品的设计与药代动力学研究
Zhaowei Chen,Jingyi Xu,Huayue Zhang et al.
Zhaowei Chen et al.
The homeostasis of branched-chain amino acids (BCAAs) plays a crucial role in maintaining health, and the accumulation of BCAAs can lead to various diseases. Therefore, exogenous degradation or conversion of excessive BCAAs may help allevia...
Three-dimensional tissue engineering and organoid technologies for retinal regeneration and therapy [0.03%]
三维视网膜组织工程与类器官技术促进视网膜再生和修复
Yiqi Wang,Douglas Jiang,Qinglong Wang et al.
Yiqi Wang et al.
The human eye, a masterpiece of evolution, orchestrates the intricate process of vision. The retina is a tissue with a layered structure that plays a critical role in converting light signals into neural impulses interpretable by the brain....
Pegah Madaninasab,Mahsa Mohammadzadeh,Sheyda Labbaf
Pegah Madaninasab
This comprehensive review explores the therapeutic potential of carbon nanomaterials, including carbon nanotubes, graphene, carbon dots, and other related materials, in wound healing applications. These materials offer a cutting-edge approa...
Development and validation of a computational tool to predict treatment outcomes in cells from high-grade serous ovarian cancer patients [0.03%]
高_grade浆液性卵巢癌患者细胞治疗结果预测计算工具的开发和验证
Marilisa Cortesi,Dongli Liu,Elyse Powell et al.
Marilisa Cortesi et al.
Treatment of High-grade serous ovarian cancer (HGSOC) is often ineffective due to frequent late-stage diagnosis and development of resistance to therapy. Timely selection of the most effective (combination of) drug(s) for each patient would...
Engineered probiotic alleviates ulcerative colitis by inhibiting M1 macrophage polarization via glycolytic reprogramming [0.03%]
通过糖酵解重构抑制M1型巨噬细胞极化从而缓解溃疡性结肠炎的工程益生菌
Chaoqun Lv,Xinyue Hu,Xiang Li et al.
Chaoqun Lv et al.
Ulcerative colitis (UC) remains a significant therapeutic challenge due to its complex pathogenesis involving oxidative stress, immune dysregulation, and gut microbiota dysbiosis. Melanin, a natural biopolymer with robust anti-inflammatory ...