Therapeutic potential and translational challenges of extracellular vesicles in neonatal medicine [0.03%]
新生儿医学中细胞外囊泡的治疗潜力和转化挑战
Ali M Atoom,Media Hamed-Ahmed,Shaker Al-Hasnaawei et al.
Ali M Atoom et al.
Extracellular vesicles (EVs) have emerged as promising therapeutic candidates for a range of neonatal diseases, including sepsis, necrotizing enterocolitis, hypoxic-ischemic encephalopathy (HIE), and bronchopulmonary dysplasia (BPD). Derive...
Kidney organoids as a novel platform to evaluate heat-stress-induced acute kidney injury pathogenesis [0.03%]
肾脏类器官作为评估高温应激诱导的急性肾损伤发病机制的新平台
Qisheng Su,Liang Yue,Leixing Ge et al.
Qisheng Su et al.
Acute kidney injury (AKI) is a serious condition with significant global impact. To explore mechanisms and biomarkers of heat-stress-induced AKI, we used human kidney organoids derived from induced pluripotent stem cells via suspension cult...
Kyung Soo Park,Yong In Cho,Samir Mitragotri et al.
Kyung Soo Park et al.
Gene therapy has advanced considerably in recent years, driven by innovations in vector engineering and a more advanced understanding of virology for clinical translation. Since 2021, the U.S. Food and Drug Administration (FDA) has approved...
Revolutionizing cancer treatment: The multifaceted role of graphene oxide in modern oncology [0.03%]
癌症治疗的革命：石墨烯氧化物在现代肿瘤学中的多方面作用
Yutong Wu,Ting Zhu,Kou Wu et al.
Yutong Wu et al.
The rising global incidence and mortality rates of cancer underscore the persistent reliance on chemotherapy as the primary treatment modality. Despite its widespread use, challenges such as chemotherapy resistance and the absence of tumor-...
Hypoxia-preconditioned MiotEVs from bone marrow mesenchymal stem cells inhibit myocardial infarction-induced cardiac fibrosis [0.03%]
骨髓间充质干细胞衍生的缺氧预处理MioExos抑制心梗诱导的心脏纤维化作用
Jungang Nie,Hongwen Zhu,Zhiming Gao et al.
Jungang Nie et al.
Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived mitochondrial extracellular vesicles (Hypoxia-BMSC MitoEVs) emerged as a novel therapeutic candidate for myocardial infarction (MI)-induced cardiac fibrosis. Here, we demonstr...
Injectable hyaluronic acid-metformin conjugate gel for sustained intra-articular delivery and prevention of post-traumatic osteoarthritis [0.03%]
用于持续性滑膜递送和预防创伤后骨关节炎的可注射透明质酸-盐酸二甲双胍共轭凝胶
Vasyl Pastukh,Jianying Zhang,Soichi Hattori et al.
Vasyl Pastukh et al.
We developed an injectable hyaluronic acid-metformin (HA-Met) conjugate gel for localized intra-articular delivery to mitigate post-traumatic osteoarthritis (PTOA). Conjugation was verified by Fourier-transform infrared spectroscopy, proton...
Precise mimicry of physiological Ca2+ oscillations for mammalian oocyte activation by nanosecond pulsed electric field [0.03%]
纳秒脉冲电场精确模拟生理钙振荡以激活哺乳动物卵母细胞
Yi-Dan Sun,Tong An,Rong Liang et al.
Yi-Dan Sun et al.
Oocyte activation deficiency is a primary cause of fertilization failure following intracytoplasmic sperm injection, a problem that can potentially be overcome through artificial oocyte activation (AOA). However, concerns persist regarding ...
Low-cost, handheld, multi-pulse electroporators for simplified nucleic acid delivery in skin [0.03%]
低成本手持多脉冲电穿孔仪用于简化皮肤核酸输送
Pankaj Rohilla,Erkan Azizoglu,Sion Park et al.
Pankaj Rohilla et al.
Electroporation-mediated delivery offers a promising alternative to carrier-based nucleic acid delivery methods for vaccination and therapeutic applications. Carrier-based systems like lipid nanoparticles and viral vectors often suffer from...
Transcatheter measurement of mitral valve coaptation pressure: A proof-of-concept study using animal models [0.03%]
经导管测量二尖瓣同闭压力：一种动物模型的验证概念研究
Joseph Faudou,Anupriya Roul,Mohammed Benwadih et al.
Joseph Faudou et al.
Mitral valve repair (MVr) is the preferred surgical treatment for primary mitral regurgitation; however, its success is limited by the lack of validated, accurate, and objective parameters for assessing the complete restoration of physiolog...
Vitrification and rapid rewarming of precision-cut liver slices for pharmacological and biomedical research [0.03%]
用于药理和生物医学研究的肝精密切片的玻璃化和快速复温
Srivasupradha Ramesh,Joseph Sushil Rao,Bat-Erdene Namsrai et al.
Srivasupradha Ramesh et al.
High-throughput in vitro pharmacological toxicity testing is essential for drug discovery. Precision-cut liver slices (PCLS) provide a robust system for screening that is representative of the complex 3D structure of the whole liver. Howeve...