Multi-modal screening for synergistic neuroprotection of mild extremely preterm brain injury [0.03%]
多模态筛选极早产儿脑损伤的协同神经保护作用
Zheyu Ruby Jin,Kylie A Corry,Olivia C Brandon et al.
Zheyu Ruby Jin et al.
Preterm brain injury affects both white and gray matter, including altered cortical development and gyrification, with associated neurodevelopmental sequelae such as cerebral palsy and learning deficits. The preterm brain also displays regi...
Pediatric dilated cardiomyopathy caused by TNNT2-R151W mutation: Modeling and rescue in patient-derived induced pluripotent stem cells and engineered heart tissue [0.03%]
TNNT2-R151W突变所致儿童扩张型心肌病的病人诱导多能干细胞和工程心脏组织中的建模与修复研究
Toshiaki Nagashima,Kenji Miki,Masaru Tsuchida et al.
Toshiaki Nagashima et al.
Dilated cardiomyopathy (DCM) is the most prevalent pediatric cardiomyopathy and has a poor prognosis. Although heart transplantation is the only curative option, the severe donor shortage in Japan underscores an urgent need for alternative ...
Dynamic and living devices for overcoming fibrosis of implanted biomaterials [0.03%]
用于克服植入生物材料纤维化的动态和活体装置
Joy M Jackson,Lolita Testu,Alex Abramson
Joy M Jackson
The fibrotic encapsulation of implantable medical devices reduces diffusion-based mass transport and electrical conductivity between the tissue and implant, limiting many devices to weeks-long rather than years-long lifetimes. Most strategi...
Neuron-targeted 2-deoxyglucose-dendrimer-rosiglitazone nanotherapy mitigates neuroinflammation and cognitive deficits in pediatric traumatic brain injury [0.03%]
神经靶向2-脱氧葡萄糖-树枝状分子-罗格列酮纳米疗法可缓解儿童创伤性脑损伤的神经炎症和认知缺陷
Aqib Iqbal Dar,Zhi Zhang,Shamila Gopalakrishnan et al.
Aqib Iqbal Dar et al.
Traumatic brain injury (TBI) remains a major global health challenge, characterized by high morbidity and mortality rates. Despite advances in neuroscience, the blood-brain barrier (BBB) limits the effectiveness of potential neuroprotective...
Olfactory ensheathing cells exosomes enhance neurological recovery in brain-injured rats by modulating Nrf2-ferroptosis pathway [0.03%]
嗅鞘细胞外泌体通过调节Nrf2-铁死亡途径促进脑损伤大鼠的神经功能恢复
Xin-Li Chen,Yi-Bin Liu,Cheng-Ye Lin et al.
Xin-Li Chen et al.
This study aimed to evaluate the therapeutic potential of the olfactory ensheathing cells (OECs) exosomes (EXOs) in traumatic brain injury (TBI) and the regulatory role of nuclear factor E2-related factor (Nrf2). Rats were divided into Sham...
Lipid stress evolved, microbiome-based probiotics reduce lipid uptake in mice [0.03%]
脂质压力的进化及基于微生物组的益生菌可降低小鼠的脂质吸收
Abhinav P Acharya,Matthew A Borrelli,Michael J Jurczak et al.
Abhinav P Acharya et al.
Controlling the molecular transport of nutrients through the gut is an attractive strategy to modulate host metabolism. Herein, a technique of stress-based evolution of an individual's own microbiota to enhance lipid metabolism is presented...
Quantitative determination of embolization endpoints based on local arterial pressure [0.03%]
基于局部动脉压的栓塞终点量化确定方法
Dongcheng Ren,Xingyuan Li,Shijie Guo et al.
Dongcheng Ren et al.
This study aims to optimize the embolization endpoint to improve therapeutic outcomes in interventional procedures and minimize the risk of ectopic embolism caused by excessive embolic agent injection. Hemodynamic changes during embolizatio...
Revolutionizing nephrocalcinosis treatment: IL-10 engineered macrophages as a novel therapeutic approach [0.03%]
革新肾钙质沉着症治疗：利用IL-10工程化巨噬细胞的新型治疗方法
Wenlei Zhao,Kailong Wang,Hairui Chen et al.
Wenlei Zhao et al.
Nephrocalcinosis provides a nidus for stone formation and is strongly linked to renal injury and chronic kidney disease. Although the crucial role of macrophages in the formation and progression of calcium oxalate (CaOx) crystals has long b...
Glioma chemotherapeutic resistance is tied to membrane electrophysiological properties and glycosylation [0.03%]
胶质瘤的化学疗法耐药性与膜电生理特性和糖基化有关
Alan Y L Jiang,Andrew R Yale,J Nicole Hanamoto et al.
Alan Y L Jiang et al.
Diffuse gliomas are brain tumors that include oligodendroglioma, astrocytoma, and glioblastoma (GBM), the most common and deadly primary brain tumor. A major challenge in glioma treatment is resistance to the first-line chemotherapeutic, te...
Patient-specific visco-hyperelastic mechanical model for breast tumor localization in surgical planning [0.03%]
用于手术规划中乳腺肿瘤定位的患者特异性黏弹塑性力学模型
Felicia Alfano,Pedro Navas,Pablo Lamata et al.
Felicia Alfano et al.
Breast-conserving surgery is typically performed with the patient in a supine position, whereas preoperative diagnostic MRI breast images are obtained with the patient in a prone position. The change in patient positioning causes significan...