Whole-tissue imaging reveals intrastrain diversity shapes the spatial organization of Pseudomonas aeruginosa in a murine infection model [0.03%]
全组织成像揭示了同种内变异影响绿脓杆菌小鼠感染模型中的空间分布
H L Fraser,D A Moustafa,J B Goldberg et al.
H L Fraser et al.
Intrastrain genetic and phenotypic heterogeneity of Pseudomonas aeruginosa is a hallmark of chronic lung infections in individuals with cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Although the coexistence of multi...
Stationary-phase Pseudomonas aeruginosa fluoroquinolone persisters mostly avoid DNA double-stranded breaks [0.03%]
静止期铜绿假单胞菌氟喹诺酮耐受细胞主要避免DNA双链断裂
Patricia J Hare,Juliet R González,Wendy W K Mok
Patricia J Hare
When susceptible bacterial cultures are treated with antibiotics, some cells can survive treatment without heritable resistance, giving rise to susceptible daughter cells in a phenomenon termed antibiotic persistence. Current models of fluo...
Plasmodium DNA ligase I is essential for parasite blood- and liver-stage development [0.03%]
毕氏疟原虫DNA连接酶I对寄生虫红血球内和肝阶段的发育是必不可少的
Eisha Pandey,Shivani Mishra,Aastha Varshney et al.
Eisha Pandey et al.
DNA ligases are a fundamental class of enzymes required for DNA replication and repair. They catalyze the formation of phosphodiester bonds, specifically at single-strand breaks in double-stranded DNA. The nuclear genome of malaria parasite...
Correlation versus causation: Helicobacter pylori population heterogeneity complicates the identification of mutant strain phenotypes [0.03%]
相关性与因果关系：幽门螺旋杆菌的种群异质性使其菌株表型的识别变得复杂
Marina R Wylie,Jeremy J Gilbreath,Angela Melton-Celsa et al.
Marina R Wylie et al.
Helicobacter pylori causes cancer in approximately 1% of infected individuals. A proposed mechanism of H. pylori persistence centers on the ability of the pathogen to form biofilms, yet little is known about specific genetic requirements fo...
N-benzyl- N-methyldithiocarbamate (BMDC) combines with metals to produce antimicrobial and anti-biofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis [0.03%]
N-苄基-N-甲基二硫代氨基甲酸盐(BMDC)与金属结合可产生抗甲氧西林耐药金黄色葡萄球菌(MRSA)和表皮葡萄球菌的抗菌和抗生物被膜作用
Yamil Sanchez-Rosario,Natasha R Cornejo,Isaiah S Gonzalez et al.
Yamil Sanchez-Rosario et al.
Methicillin-resistant Staphylococcus aureus (MRSA) is a high-priority microorganism that necessitates the development of new treatments, as it causes a substantial disease burden and economic impact globally. MRSA colonizes the skin and ant...
Ethical criteria for self-identifying societal risk associated with dangerous gain-of-function research [0.03%]
危险功能获得研究社会风险的伦理判定标准
Patricia Delarosa,C Matthew Sharkey,Kristjan Hollo
Patricia Delarosa
The 5 May 2025 executive order (EO) "Improving the safety and security of biological research" established a federal funding pause for dangerous gain-of-function (DGoF) research, defined as seeking certain experimental outcomes and deemed c...
Virome diversity and molecular characterization of two emerging RNA viruses in mosquito populations from Yantai, China [0.03%]
中国烟台蚊虫群体中两种新现RNA病毒的病毒组多样性及分子特征分析
Meixi Ren,Yumei Liu,Yongqin Wang et al.
Meixi Ren et al.
Mosquito-borne viruses represent a major global public health threat, with transmission dynamics governed by climatic, ecological, and anthropogenic factors. Yantai City, Shandong Province, situated in a warm-temperate monsoon climate zone,...
Small RNA promotes negative feedback of the master virulence regulator PhoP by repressing the PhoQ sensor enhancer UgtL in acidic pH [0.03%]
小RNA通过抑制UgtL感受态增强子以促进PhoP酸性pH下的负反馈调控
Michelle D Prophete,Alexander Mabel,Payton Bowman et al.
Michelle D Prophete et al.
Signal transduction allows bacterial pathogens to sense the host environment and regulate gene expression accordingly for adaptation and survival. While the success of infection largely depends on the timely induction of virulence genes, th...
An apicoplast-localized GTPase is essential for Toxoplasma gondii survival [0.03%]
一个定位于apicoplast的GTP酶对于维持托拉川巴氏体虫生存是必不可少的
Michael B Griffith,Morgan E Wagner,Victoria L Robsinson et al.
Michael B Griffith et al.
The apicoplast is an essential organelle found in Apicomplexa, a large phylum of intracellular eukaryotic pathogens. The apicoplast produces metabolites that are utilized for membrane biogenesis and energy production. A majority of apicopla...
Growth phase influences virulence in Candidozyma auris systemic infection models [0.03%]
克鲁维肠酵母菌系统性感染模型中生长阶段影响其致病力
Michael J McFadden,Juliet A E Anku,Faith A Davis et al.
Michael J McFadden et al.
Candidozyma auris is a growing public health concern, capable of causing long-term contamination of healthcare settings, skin colonization, and life-threatening bloodstream infections. However, C. auris pathogenesis is not well understood, ...