Ethical criteria for self-identifying societal risk associated with dangerous gain-of-function research [0.03%]
危险功能获得研究社会风险的伦理判定标准
Patricia Delarosa,C Matthew Sharkey,Kristjan Hollo
Patricia Delarosa
The 5 May 2025 executive order (EO) "Improving the safety and security of biological research" established a federal funding pause for dangerous gain-of-function (DGoF) research, defined as seeking certain experimental outcomes and deemed c...
Virome diversity and molecular characterization of two emerging RNA viruses in mosquito populations from Yantai, China [0.03%]
中国烟台蚊虫群体中两种新现RNA病毒的病毒组多样性及分子特征分析
Meixi Ren,Yumei Liu,Yongqin Wang et al.
Meixi Ren et al.
Mosquito-borne viruses represent a major global public health threat, with transmission dynamics governed by climatic, ecological, and anthropogenic factors. Yantai City, Shandong Province, situated in a warm-temperate monsoon climate zone,...
Small RNA promotes negative feedback of the master virulence regulator PhoP by repressing the PhoQ sensor enhancer UgtL in acidic pH [0.03%]
小RNA通过抑制UgtL感受态增强子以促进PhoP酸性pH下的负反馈调控
Michelle D Prophete,Alexander Mabel,Payton Bowman et al.
Michelle D Prophete et al.
Signal transduction allows bacterial pathogens to sense the host environment and regulate gene expression accordingly for adaptation and survival. While the success of infection largely depends on the timely induction of virulence genes, th...
An apicoplast-localized GTPase is essential for Toxoplasma gondii survival [0.03%]
一个定位于apicoplast的GTP酶对于维持托拉川巴氏体虫生存是必不可少的
Michael B Griffith,Morgan E Wagner,Victoria L Robsinson et al.
Michael B Griffith et al.
The apicoplast is an essential organelle found in Apicomplexa, a large phylum of intracellular eukaryotic pathogens. The apicoplast produces metabolites that are utilized for membrane biogenesis and energy production. A majority of apicopla...
Growth phase influences virulence in Candidozyma auris systemic infection models [0.03%]
克鲁维肠酵母菌系统性感染模型中生长阶段影响其致病力
Michael J McFadden,Juliet A E Anku,Faith A Davis et al.
Michael J McFadden et al.
Candidozyma auris is a growing public health concern, capable of causing long-term contamination of healthcare settings, skin colonization, and life-threatening bloodstream infections. However, C. auris pathogenesis is not well understood, ...
Microbiota diversity of Anopheles gambiae in Bankeng, southern Cameroon, and its association with Plasmodium falciparum infection [0.03%]
喀麦隆班肯格地区按蚊肠道微生物多样性和其与疟原虫感染的关系
Maurice Marcel Sandeu,Claudine Grâce Maffo Tatsinkou,Nsa Dada et al.
Maurice Marcel Sandeu et al.
Malaria control requires the coordination of different strategies due to the lack of an effective vaccine and the emerging resistance of parasites to drugs and of vectors to insecticides. Therefore, efficient and environmentally safe altern...
Allele-specific effects of mutations in the rifampin resistance-determining region (RRDR) of RpoB on physiology and antibiotic resistance in Enterococcus faecium [0.03%]
恩拉霉素耐药决定区(RRDR)突变的等位基因特异性效应及其对表型和抗性的影响
Adeline Supandy,Emma G Mills,Kyong T Fam et al.
Adeline Supandy et al.
Enterococcus faecium is a member of the human gut microbiota that has evolved into a problematic nosocomial pathogen and a leading cause of infections in hospitalized patients. Treatment of E. faecium infections is complicated by antibiotic...
APC24-7, a covalent combination of boronic acid and chelator moieties, restores β-lactam efficiency against metallo-β-lactamase-producers [0.03%]
一种硼酸和螯合剂的共价复合物APC24-7可恢复金属β-内酰胺酶产生菌对β-内酰胺类药物的敏感性
Rebekka Rolfsnes Hovd,Åsmund Kaupang,Pål Rongved et al.
Rebekka Rolfsnes Hovd et al.
β-Lactam/β-lactamase inhibitor combinations have significantly improved treatment outcomes for infections caused by serine β-lactamase (SBL)-producing pathogens. However, the continued emergence and spread of metallo-β-lactamases (MBLs)...
Results from the IceGut study: tracking the gut microbiome development from mothers and infants up to five years of age [0.03%]
IceGut研究结果：从母亲和婴儿的肠道微生物组追踪发育至五岁儿童
Agnes Thora Arnadottir,Sigurlaug Skirnisdottir,Stephen Knobloch et al.
Agnes Thora Arnadottir et al.
The infant gut microbiome plays a critical role in the early development of the immune system, brain function, metabolism, and defense against pathogens. However, data from underrepresented populations, like Iceland, with its distinct dieta...
Transcriptional and metabolic modeling analyses of developing Aspergillus fumigatus biofilms reveal metabolic shifts required for biofilm maturation [0.03%]
转录和代谢模型分析表明须霉菌生物被膜发育过程中产生了代谢转变以促进生物被膜的成熟
Charles Puerner,Kaesi A Morelli,Joshua D Kerkaert et al.
Charles Puerner et al.
Aspergillus fumigatus is a filamentous fungus found in compost and soil that can cause invasive and/or chronic disease in humans. Diagnosis and treatment of aspergillosis often occur when A. fumigatus has formed dense networks of hyphae wit...