An innovative organoid model to screen for bacteria and their metabolites that protect against inflammation-induced colonic barrier disruption [0.03%]
一种创新的类器官模型用于筛选可防止炎症引起的结肠屏障损伤的细菌及其代谢产物
Nicole Cady,Sophia R Meyer,Kwi Kim et al.
Nicole Cady et al.
Organoids provide a useful model system to study interactions between gut microbes and the activity of host tissues, including gastrointestinal (GI) barrier function. However, most organoid models have limited capacity to mimic the physiolo...
Cyclic di-AMP signaling and regulation in Staphylococcus aureus [0.03%]
金黄色葡萄球菌中 cyclic di-AMP 的信号传导与调控功能
Seonmin Lee,Ji-Hoon Kim,Taegwan Yun et al.
Seonmin Lee et al.
Cyclic di-AMP (c-di-AMP) is an essential bacterial second messenger that coordinates multiple cellular processes and is closely linked to central physiology in many bacteria. In Staphylococcus aureus, both depletion and excessive accumulati...
Protective immunity against Shigella sonnei in vaccinated and challenged adult Thai volunteers [0.03%]
泰国产疫苗受试者挑战实验对宋内志贺菌的免疫保护作用
Esther Ndungo,Dilara Islam,Siriphan Gonwong et al.
Esther Ndungo et al.
A safe, effective, and affordable vaccine that can prevent Shigella-induced diarrhea could have a significant impact on reducing morbidity and mortality in populations at risk. WRSS1, a live attenuated Shigella sonnei vaccine candidate, was...
Satoshi Kimura
Satoshi Kimura
Satoshi Kimura works in the field of RNA modification. In this mSphere of Influence article, he reflects on how the paper "Efficient and quantitative high-throughput tRNA sequencing" by G. Zheng, Y. Qin, W. C. Clark, Q. Dai, et al. (Nat. Me...
Phenotypic diversity and shared genomic determinants among isolates causing a large incidence of disseminated gonococcal infections in Canada [0.03%]
加拿大导致广泛播散性淋病感染的分离株表型多样性及共享基因组决定因素
Gursonika Binepal,Emil Jurga,Duncan Carruthers-Lay et al.
Gursonika Binepal et al.
The incidence of disseminated gonococcal infection (DGI) has remained low since the advent of antibiotics; however, a recent surge in DGI has inexplicably emerged during the past decade. In an effort to understand whether Neisseria gonorrho...
Plasmid-mediated antimicrobial resistance across One Health sectors: transmission dynamics and surveillance needs [0.03%]
“同一健康”各部门中质粒介导的抗菌药物耐药性的传播动态及监测需求
Nuha Fairusya,Rongxuan Wang,Ryo Honda
Nuha Fairusya
Antimicrobial resistance (AMR) is increasingly recognized as a One Health challenge driven by the continuous exchange of resistant bacteria and resistance determinants across human, animal, and environmental sectors. While genomic surveilla...
Acquisition of a gene cluster in Clostridioides difficile PCR ribotype 023 strains enables xylitol utilization [0.03%]
芽孢杆菌科难辨梭菌PCR型023菌株获取一个基因簇可利用木糖醇
Katherine J Wozniak,Lei Pan,Duolong Zhu et al.
Katherine J Wozniak et al.
Hundreds of ribotypes of the gastrointestinal pathogen Clostridioides difficile have emerged over the last three decades, yet the factors driving their emergence are poorly understood. Recently, there has been an increase in infections caus...
Effects of improved water, sanitation, handwashing, and nutrition on early childhood IgG immune repertoire development against Shigella and enteroinvasive Escherichia coli (EIEC) [0.03%]
改进的供水、环境卫生、洗手和营养对儿童早期针对志贺菌和侵袭性大肠杆菌的IgG免疫谱系发展的影响
Nikolina Walas,Everlyn Kamau,Minlu Zhang et al.
Nikolina Walas et al.
We studied the effects of a combined water, sanitation, handwashing, and nutritional supplementation (WSH + N) intervention on Shigella/EIEC IgG immune development among Bangladeshi children enrolled in a cluster-randomized trial. We used a...
Dissolved oxygen concentrations influence microbial community structure and key players in an oxygen minimum zone [0.03%]
溶解氧浓度影响氧气最低层中的微生物群落结构及关键菌种
Kaitlin R Dombroski,Lauren G Campbell,Robert M Morris et al.
Kaitlin R Dombroski et al.
Oxygen minimum zones (OMZs) are expanding in the global ocean. Declining oxygen can alter microbial processes that regulate carbon, nitrogen, and sulfur cycling, including pathways with the potential to produce nitrous oxide (N₂O), a poten...
mSphere Legacy: Sharing wisdom at the culmination of a scientific career [0.03%]
求知育才皆有意，妙语金句赠晚晴——致即将退休的科学家朋友们
Ira J Blader
Ira J Blader
Editorial
mSphere. 2026 Jul 15:e0037626. DOI:10.1128/msphere.00376-26 2026