Ariangela J Kozik
Ariangela J Kozik
The study of the human microbiome (mirroring broader practice across biomedical science), has historically defaulted to the use of simplified, socially constructed "boxes," such as racial and ethnic labels, that fail to accurately capture h...
Regulation of hyphal development by protein kinase A, stress-responsive MAP kinases, and calcineurin via transcription factors Sfl1 and Sfl2 in Candida albicans [0.03%]
蛋白激酶A、应激反应MAPK和钙调神经素通过转录因子Sfl1和Sfl2调节白假丝酵母菌丝发育
Misty R Peterson,Shannon Au,Andrew Nhat Ho et al.
Misty R Peterson et al.
Candida albicans is a major human fungal pathogen whose ability to undergo reversible morphological transitions between yeast and hyphal growth forms represents a key virulence trait. While the cAMP-protein kinase A (PKA) pathway is essenti...
Genomic and phenotypic analysis of ST25 A. baumannii identifies virulence-associated clades and capsular/outer core locus types [0.03%]
基因组和表型分析鉴定出ST25鲍曼不动杆菌中与毒力相关的谱系及荚膜/外核心位点类型
Antonella Migliaccio,Thibault Destanque,Marisa Haenni et al.
Antonella Migliaccio et al.
The increase in the infection caused by Acinetobacter baumannii is sustained by the selection of distinct epidemic clonal lineages, which are frequently resistant to a broad range of antimicrobials and possess virulence traits responsible f...
Design and evaluation of dual-function antimicrobial peptides FPON for gram-negative bacteria with membrane disruption and translation inhibition abilities [0.03%]
兼具裂解和抑制功能的双效抗菌肽FPON的设计及评价
Yingqi Tang,Jiye Liu,Wei Zhong et al.
Yingqi Tang et al.
The situation regarding drug resistance among gram-negative bacteria is becoming increasingly severe. While antimicrobial peptides are an ideal alternative to traditional antibiotics, single-target natural antimicrobial peptides exhibit lim...
Enterococcus faecalis induces H₂O₂-mediated epithelial cell death and enhances Candida albicans virulence in oropharyngeal candidiasis [0.03%]
粪肠球菌通过诱导表皮细胞死亡促进白色念珠菌在口咽念珠菌病中的致病性增强
Roberto Vazquez-Munoz,Amit Ranjan,Martinna Bertolini et al.
Roberto Vazquez-Munoz et al.
In immunosuppressed humans with oropharyngeal candidiasis (OPC) and in mice with experimental OPC, Candida albicans infection is associated with a bacterial imbalance characterized by significantly reduced oral microbiome diversity and the ...
Molecular evolution and diversity of isomerase-reductase clusters involved in the bacterial metabolism of glycosaminoglycans [0.03%]
糖胺聚糖细菌代谢中异构酶-还原酶簇的分子进化和多样性研究
Yu Nishimura,Kenji Okumura,Sayoko Oiki et al.
Yu Nishimura et al.
Glycosaminoglycans (GAGs), comprising uronic acids and amino sugars, are widely distributed in human tissues such as the intestine and oral cavity. Various bacteria colonize these tissues by assimilating GAGs. During GAG degradation, 4-deox...
NapR, a novel nucleoid-associated protein, regulates antioxidant defense in mycobacteria [0.03%]
一个新的核关联蛋白NapR调控分枝杆菌抗氧化防御功能
Kun Wang,Xujie Cui,Xiangyang Zhang et al.
Kun Wang et al.
Nucleoid-associated proteins (NAPs) are essential in bacteria for maintaining nucleoid architecture and regulating the expression of target genes. Although some NAPs have been well studied in certain bacterial species, their specific functi...
Randomized, placebo-controlled trial reveals the impact of dose and timing of Bifidobacterium infantis probiotic supplementation on breastfed infants' gut microbiome [0.03%]
随机对照试验揭示了剂量和时机对纯母乳喂养婴儿肠道菌群的影响
Claire E O&#x;Brien,Steven A Frese,Karina Cernioglo et al.
Claire E O&#x;Brien et al.
A dysfunctional gut microbiome has become increasingly common in infants born in high-income countries as Bifidobacterium strains no longer dominate the gut microbiome. Probiotics containing Bifidobacterium infantis have been used in breast...
Response of Candida albicans white and opaque cells to phagocytosis by macrophages suggests that opaque cells are "pre-adapted" [0.03%]
白细胞和透明细胞对巨噬细胞吞噬的反应表明透明细胞具有“预适应”性质
Matthew B Lohse,Megan E Garber,Haley Gause et al.
Matthew B Lohse et al.
Candida albicans is a normal resident of the human gut and mucosal microbiomes and also an opportunistic fungal pathogen. It undergoes several morphological transitions, one of which is white-opaque switching, where C. albicans reversibly a...
Effects of intraspecies and interspecies competition on genetic device construction and performance [0.03%]
种间及种内竞争对遗传装置构建和性能的影响
Samantha Thompson,A Robert Williams,Veronica Dill et al.
Samantha Thompson et al.
One exciting class of future genetic devices could be those deployed in microbes that join complex microbial environments in the wild. We sought to determine whether genetic parts designed for monoculture are predictable when used in co-cul...