Transcriptomic analysis of tigecycline-induced colistin collateral sensitivity in carbapenem-resistant Enterobacter cloacae complex [0.03%]
替加环素诱导碳青霉烯耐药阴沟肠杆菌复敏的转录组分析
Youtao Liang,Jiming Wu,Jisheng Zhang et al.
Youtao Liang et al.
Utilizing treatment strategies based on collateral sensitivity (CS) represents a promising approach to suppressing antibiotic resistance. Although the mechanism of CS between numerous drugs has been researched, the mechanism of CS between t...
Laura Veschetti
Laura Veschetti
Laura Veschetti works in the field of microbial genomics and adaptation. In this mSphere of Influence article, she reflects on how the work of Marvig et al. on within-host evolution of Pseudomonas aeruginosa, together with long-term evoluti...
mSphere of Influence: The power of in situ-structural biology without leaving "home" [0.03%]
不离“故园”的原位结构生物学的威力
Nicholas A Wood
Nicholas A Wood
Nicholas A. Wood works in the field of biophysics with an emphasis on in situ protein structures in microbiological systems. In this mSphere of Influence article, he reflects on the power and limitations of AlphaFold, open questions in stru...
Differential assembly and functional roles of bacterial communities in coniferous and mixed conifer-broadleaf forest soils [0.03%]
针叶林和针阔混交林土壤细菌群落的装配及功能差异
Dexing Chen,Ziyang Zhang,Shunfen Wang et al.
Dexing Chen et al.
Forest soils harbor a diverse array of bacteria that play a crucial role in nutrient cycling. However, the differential effects of coniferous versus mixed conifer-broadleaf forests on the distribution of both abundant and rare bacterial tax...
Insights into bacterial stress adaptation, host interactions, and drug resistance: key findings from the fall 2025 ASM Theobald Smith Society meeting [0.03%]
2025年秋季美国微生物学会西贝尔史密斯分会会议关键发现：细菌应激适应、宿主相互作用和药物抗性的新见解
Nitish Sharma,Madhulika Singh,Joycelyn Radeny et al.
Nitish Sharma et al.
The annual fall meeting for the Theobald Smith Society (TSS), the New Jersey Branch of the American Society for Microbiology (ASM), took place in November 2025 at Cooper Medical School of Rowan University in Camden, New Jersey. A total of 7...
Durable protection against lethal Rift Valley fever hepatitis and encephalitis following low-dose ΔNSsΔNSm vaccination in mice [0.03%]
低剂量ΔNSsΔNSm疫苗对小鼠致命的 rift 值谷热病毒性肝炎和脑炎的长期保护作用
Karina Mueller Brown,Angel M Kindsvogel,Lingqing Xu et al.
Karina Mueller Brown et al.
Rift Valley fever virus (RVFV) is a zoonotic arbovirus that infects and causes disease in both humans and livestock. In humans, RVFV infection mostly results in febrile illness but has the potential to cause severe complications such as hep...
Grant Brooke,Dalton Dacus,Rose Pollina et al.
Grant Brooke et al.
Beta human papillomaviruses (β-HPVs) are ubiquitous double-stranded DNA (dsDNA) viruses that may promote skin cancers by destabilizing the host genome. Supporting this, expression of the E6 gene from a β-HPV (β-HPV 8 E6) results in incre...
Long-term persistence of pneumococcal antibodies 5 years after a sequential PCV13 and PPSV23 vaccination in kidney transplant recipients: indications for revaccination [0.03%]
肾移植受者接种肺炎球菌结合疫苗和多糖疫苗五年后的持久体液免疫：关于加强剂的启示
Lukas van de Sand,Monika Lindemann,Kim L Völk et al.
Lukas van de Sand et al.
Pneumococcal vaccination is essential to prevent invasive Streptococcus pneumoniae infections in immunocompromised individuals, including kidney transplant recipients. Current recommendations favor single-dose immunization with higher-valen...
The IrlS2-IrlR2 two-component system is a global regulator of biofilm formation, stress adaptation, and virulence in Burkholderia pseudomallei [0.03%]
IrlS2-IrlR2双组分系统是Burkholderia pseudomallei生物膜形成、应激适应和毒力的全球调节因子
Fang Chen,Jian Luo,Yingjuan Wang et al.
Fang Chen et al.
Burkholderia pseudomallei, which causes melioidosis, is an adaptable pathogen that survives in diverse environments. Two-component systems (TCSs) play pivotal roles in bacterial signal transduction and adaptation, yet the functions of most ...
The utility of fibroblast co-culture for the maintenance of episomes in human papillomavirus-associated cancer models [0.03%]
人乳头瘤病毒相关癌症模型中纤毛共培养维持染色体外dna元件的效用
Austin J Witt,Rachel L Lewis,Xu Wang et al.
Austin J Witt et al.
Human papillomavirus-associated head and neck squamous cell carcinomas (HPV+ HNSCCs) lack early diagnostics and continue to rise in incidence. HPV16 has been detected in ~90% of HPV+ oropharyngeal cancers (HPV+ OPCs), an anatomical subset o...