mSphere of Influence: Host-pathogen interactions-the fascinating world of molecular interplay [0.03%]
施氏微刊：宿主与病原菌的互作——分子互作的精彩世界
Dilip Kumar
Dilip Kumar
Dilip Kumar is a structural biologist, working on developing novel antiviral strategies against pathogenic RNA viruses by using an integrated structural biology approach. In this mSphere of Influence article, he emphasizes how two remarkabl...
Pan-genomic insights into resistance, virulence, and stress adaptation in Clostridium perfringens from the Tibetan Plateau [0.03%]
来自青藏高原的产气荚膜梭菌泛基因组学对耐药性、毒力和应激适应性的见解
Runbo Luo,Yanxi Wan,Wanting Chen et al.
Runbo Luo et al.
Clostridium perfringens is a ubiquitous foodborne and zoonotic pathogen responsible for necrotizing enteritis, food poisoning, and gas gangrene in humans and livestock, with mortality reaching 100% in specific subtypes. The Qinghai-Tibetan ...
Persistence of azole-resistant Aspergillus fumigatus in a southeastern United States environmental hotspot: a prospective genomic study [0.03%]
氟康唑耐药烟曲霉在美國东南部环境热点地区的持续存在：一项前瞻性基因组研究
Brandi N Celia-Sanchez,Amanda R Santos,Jorge Chavez et al.
Brandi N Celia-Sanchez et al.
Aspergillus fumigatus is a globally distributed fungal pathogen that can infect humans and is commonly found in the environment. Azole antifungals are the primary treatment for A. fumigatus infections; however, the emergence of azole resist...
Targeted metatranscriptomic detection of viruses from floors for simultaneous evaluation of respiratory disease burden and viral variant identification [0.03%]
基于地板的呼吸道病毒元转录组检测方法及其在疾病负担评估和病毒变异鉴定中的应用
Amanda C Carroll,Aaron Hinz,Alexandra M A Hicks et al.
Amanda C Carroll et al.
Built environment surveillance is a proven approach for tracking disease burden of some viruses within hospitals and long-term care facilities. However, studies in clinical settings are lacking for simultaneously surveying targets in a buil...
Role of the transcription factor Wor2 in biofilm formation of Candidozyma auris [0.03%]
转录因子Wor2在耳念珠菌生物被膜形成中的作用
Marine Louvet,Jizhou Li,Maialen Areitio et al.
Marine Louvet et al.
The yeast pathogen Candidozyma (Candida) auris can form biofilms, which contribute to its virulence and nosocomial transmission. In this study, we identified the transcription factor Wor2 as a negative regulator of biofilm formation in C. a...
Bacterial alteration of redox stressors impacts environmental stability of influenza A virus [0.03%]
细菌对氧化还原胁迫因子的影响影响流感病毒的环境稳定性
Matthew R Williams,Hannah M Rowe
Matthew R Williams
Influenza A virus (IAV) causes annual morbidity and mortality and remains a constant pandemic threat due to the emergence of novel strains. Therefore, understanding the factors important in host-to-host transmission of IAV is a key control ...
New inhibitors of the Pseudomonas aeruginosa enzyme, PqsE, and methods assessing their potential to induce a conformational change via active site binding [0.03%]
用于结合活性位点并评估其潜在诱导构象变化的铜绿假单胞菌PqsE酶的新抑制剂及其检测方法
Samantha B Orr,Hannah A Jones,Margaret G O&#x;Hara et al.
Samantha B Orr et al.
Pseudomonas aeruginosa is an opportunistic pathogen known for its ability to produce virulence factors and biofilms. These, among many other traits, enable P. aeruginosa to cause infections and resist treatment with antimicrobial agents. Bo...
Liquid-infused silicone catheters reduce fungal burden and inflammation in Candidozyma auris bladder infections [0.03%]
液体浸泡硅胶导管可降低Candida auris膀胱感染中的真菌负荷和炎症反应
Alyssa Ann La Bella,Hope Akegbe,Caitlin Howell et al.
Alyssa Ann La Bella et al.
Candidozyma auris is a high-priority, emerging fungal pathogen frequently isolated from urine in healthcare settings. These isolates are often associated with indwelling urinary catheters, a primary risk factor for catheter-associated urina...
Fungal endophytes of cactus (Stenocereus spp.) as a potential alternative to alleviate drought stress in juveniles of Theobroma cacao L. ICS95 [0.03%]
茎囊霉属仙人掌内生真菌作为减轻可可幼苗干旱胁迫的潜在替代方法 ICS95
Karen Sofía Trujillo-Ortigoza,Angelis Marbello-Santrich,Juliana González-Tobón et al.
Karen Sofía Trujillo-Ortigoza et al.
Theobroma cacao, one of Colombia's most socially significant crops, faces productivity challenges due to drought. This stress can reduce growth, leaf area, and stomatal conductance (Ks) and generate reactive oxygen species. Therefore, explo...
The missing thread of One Health efforts: improper drug disposal as an overlooked driver of antimicrobial resistance [0.03%]
被忽视的驱动因素：“不合理药物处置对抗微生物耐药性的影响”
Sandip Mukhopadhyay,Falguni Debnath,Debjit Chakraborty
Sandip Mukhopadhyay
With gradual recognition of the components and the stakeholders, "One Health approach" became a global strategy for mitigating antimicrobial resistance (AMR). However, the role of improper pharmaceutical disposal, particularly antimicrobial...