Plasma proteins associated with chronic graft-versus-host disease organ involvement [0.03%]
与慢性移植物抗宿主病器官受累相关的血浆蛋白
Stephanie J Lee,Corey Cutler,Ningxin Ma et al.
Stephanie J Lee et al.
Background: Prior studies identified plasma proteins associated with chronic graft-versus-host disease (cGVHD). The goal of this cross-sectional study was to evaluate whether plasma biomarkers were associated with specifi...
Masaki Ryuzaki,Svetlana Zonis,Neil A Bhowmick et al.
Masaki Ryuzaki et al.
Locally produced nonpituitary growth hormone (npGH) promotes DNA damage accumulation and epithelial-mesenchymal transition (EMT) in aging human colon epithelium. GH receptor (GHR) and npGH are expressed in normal human prostate and benign p...
Role of CD4 T cell mannose binding lectin in Schistosoma-induced pulmonary hypertension [0.03%]
曼坦受体结合树突状细胞在肝吸虫引起肺动脉高压中的作用
Claudia Mickael,Dara C Fonseca Balladares,Rahul Kumar et al.
Claudia Mickael et al.
Schistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. It is known that adaptive immunity and specifically CD4 T cells are necessary for experimental disease pathogenesis. The lectin complement system is activated in th...
A cross model single-cell atlas reveals conserved involvement of osteopontin in polycystic kidney disease [0.03%]
跨模型单细胞图谱揭示了骨桥蛋白在多囊肾病中的保守作用
Sarah J Miller,Hua Zhong,Weidong Wu et al.
Sarah J Miller et al.
Polycystic kidney disease (PKD) arises from mutations in cilia-associated genes, such as PKD1 and PKD2, expressed in renal epithelial cells, leading to progressive kidney dysfunction and end-stage kidney disease (ESKD). PKD patients exhibit...
Characterizing enteric pathology in MPS IIIA mice suggests disease-specific vulnerability among lysosomal storage disorders [0.03%]
MPS IIIA小鼠肠病表型的特征表明溶酶体贮积症特定疾病之间的特异性关联
Ewa A Ziółkowska,Letitia L Williams,Elizabeth M Eultgen et al.
Ewa A Ziółkowska et al.
Single-Cell RNA sequencing reveals clonally-expanded CD4+ tissue-resident memory T cells in Histidyl-tRNA Synthetase-induced myositis [0.03%]
单细胞RNA测序揭示了组氨酰-tRNA合成酶诱导的肌炎中克隆扩增的CD4+tissue-resident记忆T细胞
Decheng Li,Daniel P Reay,Iago Pinal-Fernandez et al.
Decheng Li et al.
The precise mechanisms underlying the pathogenesis of idiopathic inflammatory myopathy (IIM) remain undefined. However, there has been increasing recognition that tissue-resident memory cells (TRMs) play an important role in the pathogenesi...
Progressive hypothalamic neuroinflammation in ovariectomized mice parallels aging-related transcriptomic changes in the female human hypothalamus [0.03%]
卵巢切除小鼠下丘脑神经炎症的进展与女性人类下丘脑转录组老化改变平行
Jordana Cb Bloom,Encarnación Torres,Sidney A Pereira et al.
Jordana Cb Bloom et al.
The hypothalamic changes that occur after the loss of ovarian estrogen remain poorly characterized. Here, we performed a comprehensive temporal characterization of the mouse hypothalamus following ovariectomy (OVX), combining physiological ...
IL-27 neutralization with and without antibiotics as an approach to prevent and treat neonatal sepsis [0.03%]
使用抗生素联合或不联合IL-27中和预防和治疗新生儿败血症的研究
Madhavi Annamanedi,Jessica M Povroznik,Samantha Arevalo-Marcano et al.
Madhavi Annamanedi et al.
Neonatal sepsis is a predominant cause of neonatal mortality and long-term morbidity which severely effects preterm and low birth weight newborns. Antibiotic resistance and long-term developmental issues associated with neonatal sepsis nece...
Multi-omics links microbial dysbiosis, systemic inflammation, and metabolomic disruptions to SNAE risk in treated HIV [0.03%]
多组学关联微生物群失调、全身性炎症和代谢紊乱与HIV治疗患者的肛管鳞癌风险之间的联系
Christopher M Basting,Jodi Anderson,Kevin Escandón et al.
Christopher M Basting et al.
Serious non-AIDS events (SNAEs), including non-AIDS malignancies, cardiovascular disease, and hepatic complications, remain major causes of mortality in treated HIV infection. These outcomes are driven by persistent immune activation, syste...
Performance of expanded diagnostic criteria for APECED in independent cohorts and implications for earlier diagnosis [0.03%]
独立队列中APECED扩展诊断标准的表现及对早期诊断的影响
Elise Mn Ferré,Joseph Pechacek,Monica M Schmitt et al.
Elise Mn Ferré et al.
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED/APS-1) is a monogenic autoimmune disorder of impaired central tolerance classically diagnosed by the presence of 2 out of 3 classic triad manifestations: chronic mucocut...