Mononuclear phagocyte-specific cGAS/STING targeting suppresses experimental choroidal neovascularization [0.03%]
单核吞噬细胞特异性cGAS/STING抑制可减轻实验性脉络膜新生血管生成
Le Shi,Durgadas Cherukaraveedu,Hongkwan Cho et al.
Le Shi et al.
Neovascular age-related macular degeneration (nAMD) is a major cause of blindness and is characterized by pathologic angiogenesis, specifically choroidal neovascularization (CNV). Mononuclear phagocytes (MPs), including infiltrating systemi...
Acute tubular injury versus acute interstitial nephritis in the kidney precision medicine project [0.03%]
肾脏精密医学项目中的急性肾小管损伤与急性间质性肾炎的区别
Jennifer A Schaub,Rajasree Menon,Ricardo Melo Ferreira et al.
Jennifer A Schaub et al.
BACKGROUNDAcute interstitial nephritis (AIN) is a common cause of acute kidney injury (AKI), but the diagnosis may be missed as kidney biopsies are rarely obtained when acute tubular injury (ATI) is suspected.METHODSThe Kidney Precision Med...
From aging biology to cardiac biotechnology: emerging platforms for modeling cardiac aging [0.03%]
从衰老生物学到心脏生物技术：用于模拟心脏衰老的新兴平台
Kritika Chaddha,Mabel Bartlett,Tzahi Cohen-Karni et al.
Kritika Chaddha et al.
Aging is a major contributor to cardiovascular disease and mortality in older adults. Yet most preclinical and experimental cardiac studies fail to account for age as a primary biological variable, leaving a critical gap in our understandin...
Periostin defines a pathological fibroblast program enriched in restrictive allograft syndrome [0.03%]
骨膜素定义了限制性同种异体移植综合征中病理纤维化程序的富集现象
Yudai Miyashita,Taisuke Kaiho,Yuriko Yagi et al.
Yudai Miyashita et al.
This study identifies POSTN-positive pathological fibroblasts as key contributors to fibrotic restrictive chronic lung allograft dysfunction after lung transplantation. ...
The monoclonal antibody VYD2311 potently neutralizes dominant and emerging SARS-CoV-2 variants [0.03%]
单克隆抗体VYD2311能有效中和主要流行的SARS-CoV-2变异毒株
Ian A Mellis,Madeline Wu,Kristin Daniel et al.
Ian A Mellis et al.
Deep learning-based histologic classifiers enable molecular subtyping of metastatic prostate cancer [0.03%]
基于深度学习的病理分类器能够对转移性前列腺癌进行分子分型
Zhijun Chen,Erolcan Sayar,Daniela Guevara et al.
Zhijun Chen et al.
Metastatic prostate cancer is a clinically and molecularly heterogeneous disease. Under the selective pressure of androgen receptor (AR)-directed therapies, resistant phenotypes frequently emerge, posing significant diagnostic and therapeut...
Interferon regulatory factor 5 in myeloid cells promotes obstructive nephropathy-induced renal fibrosis in vivo [0.03%]
髓系细胞干扰素调节因子5促进阻塞性肾病诱导的肾纤维化
Jia Wei,Gengyu Du,Zixia Li et al.
Jia Wei et al.
Obstructive nephropathy is a significant and preventable contributor to chronic kidney disease, yet no disease-modifying anti-fibrotic agents are currently available.We hypothesized that interferon regulatory factor 5 (IRF5) functions as a ...
IFNG-producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison's disease [0.03%]
分泌IFNG的自身反应性CD4+T细胞在Addison病小鼠模型中诱导自身免疫性肾上腺炎
Arina Andreyeva,Juraj Michalik,Veronika Niederlova et al.
Arina Andreyeva et al.
Autoimmune Addison's disease (AD) is a rare but life-threatening disorder caused by immune-mediated destruction of the adrenal cortex, and progress in therapy has been limited by insufficient mechanistic insight. Here, we establish a model ...
CXCR4 coordinates adhesion, migration, and development of human NK cells [0.03%]
CXCR4调节人NK细胞的粘附、迁移和发育
Shira E Eisman,Francesca E Grossberg,Batya S Koenigsberg et al.
Shira E Eisman et al.
Natural killer (NK) cells undergo stepwise differentiation from multipotent progenitors within secondary lymphoid tissues. Despite the central importance of the tissue microenvironment in their development, little is known about cell-cell i...
Aberrant mucin expression and keratinization distinguishing severe from mild asthma revealed by interpretable machine learning [0.03%]
可解释机器学习揭示的严重哮喘与轻度哮喘的区别：黏蛋白异常表达和角质化区分
Sagar L Kale,Augusta M Vincent,Mark A Ross et al.
Sagar L Kale et al.
Type 2 (T2) immune cells dominate the airways of mild-moderate asthma (MMA) patients with a more complex Type 1 (T1)-T2 mixed immune response evident in treatment-refractory severe asthma (SA). We hypothesized that comparing the transcripto...