Identification of distinct HIV reservoir phenotypes and associated immune landscapes [0.03%]
识别不同HIV储存库表型及其相关免疫景观
Ruoyu Wang,Aparna B Bhattacharyya,Lily Pohlenz et al.
Ruoyu Wang et al.
Virally suppressed people with HIV (PWH) remain at risk for developing comorbidities due to chronic inflammation with one potential contributor being the HIV reservoir. Associations between the CD4-reservoir and inflammation have been exten...
miR-205-5p promotes endothelial dysfunction and senescence in pulmonary fibrosis [0.03%]
miR-205-5p促进肺纤维化中的内皮功能障碍和衰老
Giuseppe Muscato,Benjamin B Roos,Sharonda Harris et al.
Giuseppe Muscato et al.
Idiopathic Pulmonary Fibrosis (IPF) is a fatal, aging-related disease characterized by persistent lung fibroblast activation, progressive lung scarring and several vascular abnormalities. We have previously demonstrated that aging-associate...
HMGB1-mediated formation of IL-33-abundant NETs drives lung-to-kidney injury in severe pneumonia-associated acute kidney injury [0.03%]
HMGB1介导的IL-33丰富型NETs形成驱动严重肺炎相关急性肾损伤中的肺至肾损伤
Mengqing Ma,Hao Zhang,Weijuan Deng et al.
Mengqing Ma et al.
Acute kidney injury (AKI) is a common and fatal complication of severe pneumonia, yet the mechanisms linking pulmonary inflammation to remote kidney injury remain poorly understood. Multicenter cohort data (n = 300) revealed that the incide...
Hemodynamic and metabolomic responses to infusion of GLP-1 agonist exenatide in pulmonary arterial hypertension [0.03%]
利拉鲁肽在肺动脉高压患者中的血流动力学和代谢组学反应研究
Chinthaka B Samaranayake,Marili Niglas,Nicoleta Baxan et al.
Chinthaka B Samaranayake et al.
Preclinical studies suggest beneficial effects of GLP-1 agonists in pulmonary arterial hypertension (PAH). This first-in-disease study evaluated acute hemodynamic effects of GLP-1 agonist, exenatide administered i.v. in patients with idiopa...
ELN orchestrates prometastatic and immunosuppressive niche in bladder cancer via TGFB1 autocrine signaling [0.03%]
通过TGFB1自分泌信号，ELN在膀胱癌中调控促进转移和免疫抑制的生态位
Wentao Xu,Jia Gao,Shanshan Wu et al.
Wentao Xu et al.
Bladder cancer (BCa) mortality is mainly driven by metastatic dissemination and an immunosuppressive tumor microenvironment. Here, we identify ELN (tropoelastin), an extracellular matrix protein abundantly secreted by cancer-associated fibr...
CD11c+ CD8 T cells cause IFN-γ-dependent autoimmune neuroinflammation that is restrained by PD-1 signaling [0.03%]
CD11c+ CD8 T细胞引发的IFN-γ依赖性自身免疫神经炎症受到PD-1信号通路的抑制
Daniel Hwang,Gholamreza Azizi,Larissa Lumi Watanabe Ishikawa et al.
Daniel Hwang et al.
In multiple sclerosis (MS) lesions, CD8 T cells outnumber CD4 T cells, suggesting that they contribute to MS pathology. However, little is known about the role of CD8 T cells in MS, partly due to the prevalent use of experimental autoimmune...
Distinct immune landscapes characterize highly versus minimally invasive brain metastases [0.03%]
不同的免疫微环境特征高度侵袭性与低度侵袭性脑转移瘤
Sarah M Maritan,Elham Karimi,Matthew Dankner et al.
Sarah M Maritan et al.
Brain metastases (BrMs) occur in approximately 30% of cancer patients, causing nearly one-fifth of cancer deaths. While immune checkpoint inhibitors (ICIs) benefit some BrM patients, responses remain highly variable. This variability partly...
Overexpression of small-conductance Ca2+-activated K+ channel 2 attenuates pain-like behavior in female mice with cystitis [0.03%]
小导管钙激活钾通道2过度表达可减轻女性膀胱炎样行为疼痛
Guadalupe Manrique-Maldonado,Xuejiao Sun,Allison L Marciszyn et al.
Guadalupe Manrique-Maldonado et al.
Small-conductance Ca2+-activated K+ (SK) channels regulate neuronal excitability and act as a feedback mechanism to limit firing during sustained stimulation. In the present study, we demonstrated that SK2 plays an important role in the con...
Glucosamine links hyperglycemia to mTORC1 activation and glucose toxicity in diabetes [0.03%]
葡萄糖胺连接高血糖与糖尿病中的mTORC1激活和葡萄糖毒性
Yael Riahi,Aviram Kogot-Levin,Ziv Teselpapa et al.
Yael Riahi et al.
Hyperglycemia is a principal driver of β cell failure and multiple-organ complications in diabetes. Chronic exposure to hyperglycemia overstimulates mTORC1, disrupting glucose metabolism and promoting ER stress, oxidative stress, and infla...
Gregory D Whitehill,Alexis V Stephens,Timothy J Thauland et al.
Gregory D Whitehill et al.
BACKGROUNDCoccidioidomycosis ranges from self-limiting uncomplicated Valley fever (UVF) in most cases to life-threatening disseminated coccidioidomycosis (DCM) in rare individuals. A few patterns of immunologic deficits allowing for dissemi...