Refining cell-type annotation and fibrotic comparisons in chronic lung allograft dysfunction in single-cell RNA-seq studies [0.03%]
单细胞RNA测序研究中慢性肺移植受者细胞类型注释和纤维化比较的细化工作
Allen Duong,Sajad Moshkelgosha,Tereza Martinu et al.
Allen Duong et al.
This commentary contextualizes recent findings in chronic lung transplant rejection, highlighting challenges in cell classification and the need for disease-specific fibrosis research. ...
Mitochondrial dysfunction underlies cell cycle arrest and tubular hypoplasia in ClC-Kb-deficient Bartter syndrome mice [0.03%]
克氏症候群基因ClC-Kb缺陷小鼠近端肾小管发育不全和细胞凋亡源于线粒体功能异常
Chiao-Hui Hsieh,Yu-Jen Chen,Chih-Chien Sung et al.
Chiao-Hui Hsieh et al.
The pathogenesis of Bartter syndrome (BS) has long been attributed to decreased salt reabsorption in the thick ascending limb of Henle's loop (TAL). By studying Clc-k2-KO (mouse ortholog of ClC-Kb-KO [Clc-k2-/-]) mice, we recently uncovered...
The pleural tuberculosis-associated microenvironment promotes HIV-1 persistence by impairing CD8+ T cell-mediated viral control [0.03%]
胸膜结核相关微环境通过损害CD8⁺T细胞介导的病毒控制来促进HIV-1持续存在
Samantha Cronin,Jennifer Simpson,Andrea Pereyra-Casanova et al.
Samantha Cronin et al.
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the most common coinfection in people living with HIV-1. This coinfection is associated with accelerated HIV-1 disease progression and reduced survival. However,...
Histopathology and spatial transcriptomics jointly map myofiber-specific pathological programs in mTORC1-driven myopathy [0.03%]
mTORC1驱动的肌病中联合应用组织病理学和空间转录组学揭示肌纤维特异性病理程序
Jer-En Hsu,Qingyang Zhao,Weiqiu Cheng et al.
Jer-En Hsu et al.
Skeletal muscle is composed of heterogeneous myofiber types and non-myocyte populations. Myopathies occur in many diseases, but the mechanisms driving these pathologies remain largely unknown, partly because conventional approaches cannot l...
Lactate controls glomerular endothelial barrier integrity in lupus nephritis [0.03%]
乳酸控制狼疮性肾炎中的肾小球内皮屏障完整性
Jiaxin Lei,Xingyu Zhai,Yixin Wang et al.
Jiaxin Lei et al.
Systemic lupus erythematosus (SLE) is a progressive autoimmune disease that affects multiple organs and tissues, with lupus nephritis (LN) as one of its most severe complications. Although LN progression is associated with compromised perme...
Pan-African hybridization of PfSPZ increases antigenic diversity and replicative capacity for malaria vaccine design [0.03%]
泛非洲恶性疟原虫(PfSPZ)杂交增加疟疾疫苗设计的抗原多样性及增殖能力
Lucia Pazzagli,Bethany Jenkins,Ankit Dwivedi et al.
Lucia Pazzagli et al.
Plasmodium falciparum sporozoite (PfSPZ) vaccines, composed of aseptic, purified, live parasites that arrest during or just after liver-stage development, show excellent safety and efficacy in humans. They can induce complete protection aga...
Chronic Hypertension Impairs Lymphatic Drainage in Deep Cervical Lymph Nodes [0.03%]
慢性高血压会损害颈部深部淋巴结的淋巴引流功能
Kaiming Xu,Ankita Bhardwaj,Sunil Koundal et al.
Kaiming Xu et al.
The glymphatic-meningeal pathway, important for brain homeostasis, depends on the drainage function of the cervical lymphatic system. Although new therapies aim to modulate this pathway, a lack of methods for quantifying lymphatic drainage ...
SMOC2 promotes partial epithelial-to-mesenchymal transition and maladaptive repair in renal tubular epithelial cells [0.03%]
SMOC2促进肾小管上皮细胞部分上皮间质转化及不良修复反应
Schrodinger Cenatus,Peng Gao,Nathalie Henley et al.
Schrodinger Cenatus et al.
Chronic kidney disease is a global health concern characterized by maladaptive repair processes leading to kidney fibrosis. Following injury, early alterations in the extracellular matrix precede the development of kidney fibrosis and repre...
Mononuclear phagocyte-specific cGAS/STING targeting suppresses experimental choroidal neovascularization [0.03%]
单核吞噬细胞特异性cGAS/STING抑制可减轻实验性脉络膜新生血管生成
Le Shi,Durgadas Cherukaraveedu,Hongkwan Cho et al.
Le Shi et al.
Neovascular age-related macular degeneration (nAMD) is a major cause of blindness and is characterized by pathologic angiogenesis, specifically choroidal neovascularization (CNV). Mononuclear phagocytes (MPs), including infiltrating systemi...
Acute tubular injury versus acute interstitial nephritis in the kidney precision medicine project [0.03%]
肾脏精密医学项目中的急性肾小管损伤与急性间质性肾炎的区别
Jennifer A Schaub,Rajasree Menon,Ricardo Melo Ferreira et al.
Jennifer A Schaub et al.
BACKGROUNDAcute interstitial nephritis (AIN) is a common cause of acute kidney injury (AKI), but the diagnosis may be missed as kidney biopsies are rarely obtained when acute tubular injury (ATI) is suspected.METHODSThe Kidney Precision Med...