CRISPR/Cas-Based Electrochemical Biosensor for Human Immunodeficiency Virus-1 Nucleic Acid Amplification-Free Detection to the Attomolar Level [0.03%]
基于CRISPR/Cas的电化学生物传感器可直接检测艾滋病病毒DNA至阿托摩尔级别
Lingxuan Qu,Lingyi Meng,Xilin Sun et al.
Lingxuan Qu et al.
Aiming at realizing field detection during HIV-1 patient screening in developing countries and point of care testing (POCT) of virus levels in HIV-1 patients receiving medication, an urgent demand for portable nucleic acid detection technol...
Real-Time, Light-Activated, and Multiplexed Monitoring of Base Excision Repair in Living Cells Using Chimeric d/l-DNA Molecular Beacons [0.03%]
用于活细胞中基底切除修复的实时、光控及复用监测的嵌合d/l- DNA分子信标技术
Rosemarie Elloisa P Acero,Charles E Deckard rd,Jonathan T Sczepanski
Rosemarie Elloisa P Acero
Base excision repair (BER) is a biologically and biomedically important cellular pathway responsible for repairing common DNA lesions. As a central member of the BER pathway, apurinic/apyrimidinic endonuclease 1 (APE1) is important in DNA r...
Reflection-Enhanced Raman Identification of Single Bacterial Cells Patterned Using Capillary Assembly [0.03%]
微流控组装单细菌的表面增强拉曼识别
Joong Bum Lee,Eojin Rho,Minjoon Kim et al.
Joong Bum Lee et al.
Raman spectroscopy is an enticing tool for the rapid identification of pathogenic bacteria and has the potential to meet the demand for early diagnosis and timely treatment of patients. However, it remains a challenge to devise a reliable R...
3D-Printed CNT-Reinforced Bioresorbable Vascular Scaffold with Enhanced Mechanical Stability and Integrated Wireless Pressure Sensor for Continuous Hemodynamic Monitoring [0.03%]
一种集成了无线压力传感器的增强型机械稳定性的3D打印CNT增强型可降解血管支架用于连续血流动力学监测
Nomin-Erdene Oyunbaatar,Jinliang Wei,Lei Wang et al.
Nomin-Erdene Oyunbaatar et al.
Polymer-based bioresorbable vascular scaffolds (BVS) have garnered significant attention in biomedical applications. Among various BVS, polycaprolactone (PCL)-based scaffolds exhibit excellent biocompatibility, flexibility, chemical stabili...
Temporal Profiling of Cytokines in Passively Expressed Sweat for Detection of Infection Using the AWARE Device [0.03%]
基于AWARE设备的被动式取汗检测感染病原引起细胞因子动态变化初步探索研究
Preeti Singh,Akash Kumar,Kundan Kumar Mishra et al.
Preeti Singh et al.
This study highlights the assay development of a wearable AWARE-SENSOR (a wearable awareness with real-time exposure) designed for the noninvasive detection of key pro-inflammatory cytokines, TNF-α and IL-6, in passively perspired sweat. T...
Stabilizing Ti(III) Species in Black TiO2 via a Phosphate Capping Layer for Sub-Parts-per-Billion-Level NO2 Detection at Room Temperature [0.03%]
室温下通过磷酸盐封端层稳定黑钛白中的Ti(III)用于低至ppb级NO2检测
Haiquan Wang,Jilong Zheng,Yang Du et al.
Haiquan Wang et al.
The requirement of a high operating temperature to achieve sufficient sensitivity is a common challenge for metal oxide semiconductor (MOS)-based chemiresistive gas sensors because of their intrinsic poor conductivity and scarce active site...
Background-Free Surface-Enhanced Raman Scattering Aptasensor for Ultrasensitive Aβ40 Detection [0.03%]
一种用于检测Aβ40的高灵敏度背景-free表面增强拉曼散射适配子传感器
Guolin Hong,Xiaoyi Chen,Yuanyuan Yang et al.
Guolin Hong et al.
The quantitative and ultrasensitive detection of amyloid-beta peptides Aβ40 in blood is considered as a powerful strategy for early screening of Alzheimer's disease (AD). In this study, combining dual-aptamer recognition and magnetic-induc...
A Wearable Enzymatic Uric Acid Sensor on Microfluidics-on-Fabrics with Octadecane (C18) Modification [0.03%]
基于十八烷(C18)修饰的织物微流体无酶尿酸传感器
Tao Zhang,John A Terrell,Hui Chen et al.
Tao Zhang et al.
This study introduces a technology for creating microfluidic devices on garments and an octadecane (C18) modification of the fabric-based microfluidics, representing a novel wearable chemical sensing platform. Integrating microfluidics dire...
Tracking Intracellular Labile Iron with a Genetically Encoded Fluorescent Reporter System Based on Protein Stability [0.03%]
基于蛋白质稳定性的遗传编码荧光报告系统监测细胞内易变铁离子动态分布的新方法
Ali Akyol,Şeyma Çimen,Benjamin Gottschalk et al.
Ali Akyol et al.
Here, we developed IronFist, a genetically encoded fluorescent reporter that enables dynamic tracking of labile ferrous ions (Fe2+) in live cells. IronFist is a bicistronic system combining the iron-sensitive hemerythrin-like (Hr) domain fr...
Skin-Conformal Multifunctional Microfluidic Colorimetric Detection Device for Multiplexed Sweat Analysis [0.03%]
一种用于汗液多重分析的皮肤贴合型多功能微流体比色检测装置
Fang Li,Nuotong Shen,Limin Zhang et al.
Fang Li et al.
Real-time and in situ sweat analysis provides a straightforward, economical, convenient, and noninvasive method for monitoring human health and diagnosing diseases at an early stage. In this study, a flexible, skin-interfaced, multifunction...