An Innovative Machine Learning Based Multistage Signal Amplification Method Breaks through the Detection Limits of Conventional Optical Sensors [0.03%]
一种基于机器学习的多级信号放大方法突破了传统光电传感器的检测极限
Yihui Yang,Jiawei Liang,Hongli Fan et al.
Yihui Yang et al.
Surface plasmon resonance (SPR) enables in situ, label-free, real-time molecular detection. However, traditional SPR biosensors require complex and precise large-scale equipment, with detection limits constrained by multiple factors, compli...
An Enhanced Red Bioluminescent Indicator for Responsive Detection of Physiological Calcium Dynamics in Cells and Mice [0.03%]
用于细胞和活体小鼠生理钙离子动态响应检测的增强型红色生物发光指示剂
Xiaodong Tian,Yiyu Zhang,Haoyang Du et al.
Xiaodong Tian et al.
Calcium (Ca2+) is a crucial metal ion and signaling messenger. While bioluminescent indicators for Ca2+ have emerged as powerful imaging tools, their performance has been suboptimal. In this study, we developed an enhanced bioluminescent re...
Dual-Pathway Lateral Flow Assay for Rapid and Sensitive SARS-CoV-2 RNA Detection via CRISPR/Cas13a-Mediated SERS [0.03%]
基于CRISPR/Cas13a介导的SERS的双通道 lateral flow试纸条法实现快速灵敏检测SARS-CoV-2RNA
Younju Joung,Do Kyoung Han,Hyowon Jang et al.
Younju Joung et al.
Reverse transcription-polymerase chain reaction (RT-PCR) has been the gold standard for SARS-CoV-2 detection during the COVID-19 pandemic. However, its requirement for RNA-to-DNA conversion, reliance on centralized laboratory infrastructure...
Harnessing the Power of a H2O2-Activated Theranostic Probe against Doxorubicin-Induced Cardiotoxicity [0.03%]
一种用于对抗多柔比星引起的心脏毒性的H2O2激活型诊疗探针
Zhixing Cao,Jia Li,Wenya Yang et al.
Zhixing Cao et al.
Doxorubicin (Dox) is a highly effective antitumor drug with established therapeutic benefits across various tumor types, whose non-negligible and potent side effect is the Dox-induced cardiotoxicity (DIC). Early diagnosis of DIC is difficul...
Plasmonic Fiber Optic Sensing Platform for Point-of-Care Pharmacokinetic Monitoring of Platinum Chemotherapeutics: Toward Ultratrace Multi-omics Precision Chemotherapy Management [0.03%]
用于床边铂基化疗药物药代动力学监测的等离子体光纤传感平台：迈向超痕量多组学精准化疗管理
Yifan Duan,Jiahui Jin,Shenqi Yang et al.
Yifan Duan et al.
Precision chemotherapy management requires efficient and ultrasensitive dynamic monitoring of drug pharmacokinetics alongside real-time tracking of critical biomarker responses, yet existing clinical diagnostic systems neither achieve real-...
Multimodal Sensing Smart Skin System for Wide-Range and High-Sensitivity Stress Detection [0.03%]
广范围高灵敏度应力检测的多模态感知电子皮肤系统
Bocheng Wang,Boya Chang,Kerui Li et al.
Bocheng Wang et al.
In natural environments, mechanical stress interactions manifest across multiple orders of magnitude in intensity. Conventional single-mechanism mechanical sensors exhibit constrained dynamic detection ranges, presenting fundamental limitat...
PtNPs/Prussian Blue-Modified Microelectrode Arrays for Detection of Key Neurons Regulating Hibernation State [0.03%]
修饰的微电极阵列用于检测调节冬眠状态的关键神经元
Yiding Wang,Chao Yang,Yilin Song et al.
Yiding Wang et al.
Studying neuronal activity during hibernation's extremely low metabolic state may offer novel solutions for metabolic disorders, stroke treatment, and space travel challenges. To explore hibernation's neural mechanisms, we developed a natur...
Absolute Quantitative Detection of Hypervirulent Klebsiella pneumoniae Using a Novel Silicon-Doped Carbon Quantum Dot-Probe-Graphene Oxide [0.03%]
一种新型掺硅碳量子点探针石墨烯氧化合物用于绝对定量检测高毒性的肺炎克雷伯氏菌
Lijuan Huang,Bing Du,Xiaohu Cui et al.
Lijuan Huang et al.
Klebsiella pneumoniae (Kpn) is a common opportunistic pathogen, with hypervirulent strains (hvKpn) posing significant risks even to healthy individuals. Traditional clinical diagnostics often use real-time quantitative polymerase chain reac...
Coreaction Accelerator Au Nanoparticle-Confined Coordination Polymers with Highly Efficient Electrochemiluminescence for Sensitive Detection of Neurological Disease Biomarkers [0.03%]
一种新型核壳结构高效电化学发光纳米探针用于神经退行性疾病标志物检测
Li Song,Yilan Ding,Shuchun Bu et al.
Li Song et al.
In this study, a highly efficient electrochemiluminescent (ECL) coordination polymer, Au-Zn-DTBA, was synthesized by employing 2,2'-dithiodibenzoic acid (DTBA) as the luminescent ligand and Zn2+ as the metal node as well as Au nanoparticles...
Active Microfluidic Platforms for Particle Separation and Integrated Sensing Applications [0.03%]
用于粒子分离和集成感测应用的微流控平台
Tianlong Zhang,Tianyuan Zhou,Qi Cui et al.
Tianlong Zhang et al.
The active manipulation and separation of particles in microfluidic systems using externally applied forces, such as acoustic, electric, magnetic, and optical fields, have transformed our capacity to detect pathogens, biomarkers, and enviro...