Esophageal cancer research today and tomorrow: Lessons from algae and other perspectives [0.03%]
今天的食管癌研究及未来展望——从藻类和其他视角获得的启示
Vladlena Tiasto,Valeriia Mikhailova,Valeriia Gulaia et al.
Vladlena Tiasto et al.
Esophageal cancer is an increasing concern due to poor prognosis, aggressive disease modalities, and a lack of efficient therapeutics. The two types of esophageal cancer: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcino...
Rpb5, a subunit shared by eukaryotic RNA polymerases, cooperates with prefoldin-like Bud27/URI [0.03%]
真核RNA聚合酶的共同亚基Rpb5与分子伴侣Bud27/URI协同作用
Verónica Martínez-Fernández,Francisco Navarro
Verónica Martínez-Fernández
Rpb5 is one of the five common subunits to all eukaryotic RNA polymerases, which is conserved in archaea, but not in bacteria. Among these common subunits, it is the only one that is not interchangeable between yeasts and humans, and accoun...
Identification of a novel functional miR-143-5p recognition element in the Cystic Fibrosis Transmembrane Conductance Regulator 3'UTR [0.03%]
鉴定出一个新的功能性miR-143-5p识别元件位于囊性纤维化跨膜转导调节器3'非翻译区中
Chiara De Santi,Sucharitha Gadi,Agnieszka Swiatecka-Urban et al.
Chiara De Santi et al.
MicroRNAs (miRNAs) are small non-coding RNAs involved in regulation of gene expression. They bind in a sequence-specific manner to miRNA recognition elements (MREs) located in the 3' untranslated region (UTR) of target mRNAs and prevent mRN...
Time-dependent modulation of FoxO activity by HDAC inhibitor in oncogene-transformed E1A+Ras cells [0.03%]
表皮生长因子E1A和Ras双转基因细胞中组蛋白去乙酰化酶抑制剂对FoxO活性的时序调节作用研究
Alisa Morshneva,Olga Gnedina,Svetlana Svetlikova et al.
Alisa Morshneva et al.
HDAC inhibitors (HDACIs) induce irreversible cell cycle arrest and senescence in mouse embryonic fibroblasts transformed with E1A and c-Ha-Ras oncogenes (E1A+Ras cell line). The aging rate has been associated with the production of high lev...
Our love-hate relationship with DNA barcodes, the Y2K problem, and the search for next generation barcodes [0.03%]
我们的爱恨情仇：DNA条形码、千禧年问题以及下一代条形码的寻找之旅
Jeffrey M Marcus
Jeffrey M Marcus
DNA barcodes are very useful for species identification especially when identification by traditional morphological characters is difficult. However, the short mitochondrial and chloroplast barcodes currently in use often fail to distinguis...
High frequency of microdeletion in TTY2 gene family in peripheral blood leukocytes of non-obstructive azoospermia patients [0.03%]
非梗阻性无精子症患者外周血白细胞中TTY2基因家族微缺失高频检出
Farideh Zonozi,Hossein Mozdarani,Mahdieh Salimi et al.
Farideh Zonozi et al.
About 10-15% of non-obstructive azoospermia (NOA) patients show AZFc microdeletion in their blood leukocytes. However, if AZF genes were involved in impaired spermatogenesis, a higher frequency of chromosomal microdeletions was expected. In...
Evidence for two types of nrDNA existing in Chinese medicinal fungus Ophiocordyceps sinensis [0.03%]
冬虫夏草中存在两种核糖体DNA类型的证据
Chih-Sheng Chen,Ching-Tsan Huang,Ruey-Shyang Hseu
Chih-Sheng Chen
Nuclear ribosomal DNA (nrDNA) sequences are widely used in the molecular classification of fungi. Previous phylogenetic studies of highly-valued traditional Chinese medicinal fungus Ophiocordyceps sinensis were mostly based on 18S and inter...
The use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studies [0.03%]
基因毒性生物标志物在环境、职业和饮食研究中的分子流行病学应用
Carina Ladeira,Lenka Smajdova
Carina Ladeira
Molecular epidemiology is an approach increasingly used in the establishment of associations between exposure to hazardous substances and development of disease, including the possible modulation by genetic susceptibility factors. Environme...
In-silico based identification and functional analyses of miRNAs and their targets in Cowpea (Vigna unguiculata L.) [0.03%]
基于计算机的田间识别及对美洲花生（Vigna unguiculata L.）中miRNA及其靶基因的功能分析
Zareen Gul,Muhammad Younas Khan Barozai,Muhammad Din
Zareen Gul
Cowpea (Vigna unguiculata L.) is an important leguminous plant and a good diet due to presence of carbohydrate and high protein contents. Currently, only few cowpea microRNAs (miRNAs) are reported. This study is intended to identify and fun...
DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity [0.03%]
脂质过氧化产物所致的 DNA 损伤及其在癌症、炎症和自身免疫病中的作用
Fabrizio Gentile,Alessia Arcaro,Stefania Pizzimenti et al.
Fabrizio Gentile et al.
Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage and excess caloric intake cause generalized DNA damage, producing genotoxic and mutagenic effects. The consequent deregulation of cell homeostasis i...