Time-dependent modulation of FoxO activity by HDAC inhibitor in oncogene-transformed E1A+Ras cells
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HDAC inhibitors (HDACIs) induce irreversible cell cycle arrest and senescence in mouse embryonic fibroblasts transformed with E1A and c-Ha-Ras oncogenes (E1A+Ras cell line). The aging rate has been associated with the production of high levels of Reactive Oxyg... ...
