MicroRNA-based screens for synthetic lethal interactions with c-Myc [0.03%]
基于微小核糖核酸的合成致死与c-Myc相互作用筛选
Youjun Li,Yahui Zhu,Edward V Prochownik
Youjun Li
microRNAs (miRs) are small, non-coding RNAs, which play crucial roles in the development and progression of human cancer. Given that miRs are stable, easy to synthetize and readily introduced into cells, they have been viewed as having pote...
Links between mRNA splicing, mRNA quality control, and intellectual disability [0.03%]
关于信使RNA剪接、信使RNA质量检测和智力障碍之间的联系
Milo B Fasken,Anita H Corbett
Milo B Fasken
In recent years, the impairment of RNA binding proteins that play key roles in the post-transcriptional regulation of gene expression has been linked to numerous neurological diseases. These RNA binding proteins perform critical mRNA proces...
The miR-132/212 locus: a complex regulator of neuronal plasticity, gene expression and cognition [0.03%]
miR-132/212位点：调控神经可塑性、基因表达和认知的复杂因子
Sydney Aten,Katelin F Hansen,Kari R Hoyt et al.
Sydney Aten et al.
The microRNA (miRNA) class of small (typically 22-24 nt) non-coding RNA affects a wide range of physiological processes in the mammalian central nervous system (CNS). By acting as potent regulators of mRNA translation and stability, miRNAs ...
DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes [0.03%]
.DEAH-RHA解旋酶•锌指因子系统在克氏菌类RNA编辑及进化上距离甚远的RNA过程中的作用
Jorge Cruz-Reyes,Blaine H M Mooers,Zakaria Abu-Adas et al.
Jorge Cruz-Reyes et al.
Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicase•zinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which inc...
Functional interplay between PPM1G and the transcription elongation machinery [0.03%]
PPM1G与转录延长机制的相互作用
Swapna Aravind Gudipaty,Iván D&#x;Orso
Swapna Aravind Gudipaty
Transcription elongation is a critical regulatory step in the gene expression cycle. One key regulator of the switch between transcription initiation and elongation is the P-TEFb kinase, which phosphorylates RNA polymerase II (Pol II) and s...
Fast-forward generation of effective artificial small RNAs for enhanced antiviral defense in plants [0.03%]
用于增强植物抗病毒防御的有效人工小RNA的快速生成方法
Alberto Carbonell,James C Carrington,José-Antonio Daròs
Alberto Carbonell
Artificial small RNAs (sRNAs) are short ≈21-nt non-coding RNAs engineered to inactivate sequence complementary RNAs. In plants, they have been extensively used to silence cellular transcripts in gene function analyses and to target invadin...
The converging roles of BRD4 and gene transcription in pluripotency and oncogenesis [0.03%]
BRD4和基因转录在多能性和肿瘤发生中的作用收敛性
Tao Wu,Mary E Donohoe
Tao Wu
MiR-506: A Multitasker in Suppression of the Epithelial-to-Mesenchymal Transition [0.03%]
miR-506：上皮细胞-间充质转化抑制过程中的多面手
Yan Sun,Delia Mezzanzanica,Wei Zhang
Yan Sun
MiRNAs emerge as important regulators of epithelial-to-mesenchymal transition (EMT). The Best known EMT regulatory miRNAs are targeting the transcriptional repressors of E-cadherin (E-cad). We identified miR-506 as a key EMT inhibitor throu...
MicroRNA-133α regulates neurotensin-associated colonic inflammation in colonic epithelial cells and experimental colitis [0.03%]
MicroRNA-133α通过调节神经紧张素相关结肠炎症影响结肠上皮细胞及实验性结肠炎
Ivy Ka Man Law,Charalabos Pothoulakis
Ivy Ka Man Law
Ulcerative colitis (UC) and Crohn's Disease (CD) are the two most common forms of Inflammatory Bowel Diseases (IBD) marked by chronic and persistent inflammation. Neurotensin (NT), together with its receptor, NT receptor 1 (NTR1), are impor...
Cen Zhang,Juan Liu,Xiaolong Wang et al.
Cen Zhang et al.
Tumor suppressor p53 and its signaling pathway play a central role in tumor prevention. The E3 ubiquitin ligase MDM2, which is a direct p53 transcriptional target and also the most critical negative regulator of p53, forms an autoregulatory...