Julia de Amorim,Anne Slavotinek,Milo B Fasken et al.
Julia de Amorim et al.
Exosomopathies are a collection of rare diseases caused by mutations in genes that encode structural subunits of the RNA exosome complex (EXOSC). The RNA exosome is critical for both processing and degrading many RNA targets. Mutations in i...
Justin Halman,Emily Satterwhite,Jaclyn Smollett et al.
Justin Halman et al.
The targeted and conditional activation of pharmaceuticals is an increasingly important feature in modern personalized medicine. Nucleic acid nanoparticles show tremendous potential in this exploit due to their programmability and biocompat...
Ziad El Tannir,Kirill A Afonin,Bruce A Shapiro
Ziad El Tannir
Control over the delivery of different functionalities and their synchronized activation in vivo is a challenging undertaking that requires careful design and implementation. The goal of the research highlighted herein was to develop a plat...
Matthew F Jones,Toshifumi Hara,Ashish Lal
Matthew F Jones
Human cancers are driven by genetic mutations which cause aberrant activation of pro-growth pathways. Although cancers are uniquely dependent on the pro-growth signaling from oncogenic pathways, efforts to directly target these have been la...
One aptamer, two functions: the full-length aptamer inhibits AMPA receptors, while the short one inhibits both AMPA and kainate receptors [0.03%]
一个适配子具有两种功能：全长的适配子抑制AMPA受体，而短序列的适配子同时抑制AMPA和kainate受体
William J Jaremko,Zhen Huang,Wei Wen et al.
William J Jaremko et al.
AMPA and kainate receptors, along with NMDA receptors, are distinct subtypes of glutamate ion channels. Excessive activity of AMPA and kainate receptors has been implicated in neurological diseases, such as epilepsy and neuropathic pain. An...
The miR-125a and miR-320c are potential tumor suppressor microRNAs epigenetically silenced by the polycomb repressive complex 2 in multiple myeloma [0.03%]
miR-125a和miR-320c是多发性骨髓瘤中被Polycomb抑制复合物2表观遗传沉默的潜在抑癌microRNA
Mohammad Alzrigat,Helena Jernberg-Wiklund
Mohammad Alzrigat
We have previously presented the histone methyltransferase enhancer of zeste homolog 2 (EZH2) of the polycomb repressive complex 2 (PRC2) as a potential therapeutic target in Multiple Myeloma (MM). In a recent article in Oncotarget by Alzri...
microRNA-29 mediates a novel negative feedback loop to regulate SCAP/SREBP-1 and lipid metabolism [0.03%]
微小核糖核酸-29通过新型负反馈环调节SCAP/SREBP-1和脂质代谢
Peng Ru,Deliang Guo
Peng Ru
The membrane-bound transcription factors, SREBPs (sterol regulatory element-binding proteins), play a central role in regulating lipid metabolism. The transcriptional activation of SREBPs requires the key protein SCAP (SREBP-cleavage activa...
Antisense Oligonucleotides: Treatment Strategies and Cellular Internalization [0.03%]
反义寡核苷酸：治疗策略及细胞内吞机制
Colton M Miller,Edward N Harris
Colton M Miller
The clinical applicaton of antisense oligonucleotides (ASOs) is becoming more of a reality as several drugs have been approved for the treatment of human disorders and many others are in various phases in development and clinical trials. AS...
The anti-melanoma activity and oncogenic targets of hsa-miR-15a-5p [0.03%]
hsa-miR-15a-5p的抗黑色素瘤活性及其致癌靶点研究
Christopher Alderman,Yixin Yang
Christopher Alderman
MiRNAs regulate gene expression post-transcriptionally and pre-translationally. Through gene regulation, several miRNAs have been found to play a significant role in various diseases. Each miRNA has multiple targets and is able to have a po...
A novel microRNA-1207-3p/FNDC1/FN1/AR regulatory pathway in prostate cancer [0.03%]
前列腺癌中新型的microRNA-1207-3p/FNDC1/FN1/AR调节通路
Dibash K Das,Olorunseun O Ogunwobi
Dibash K Das
Prostate cancer (PCa) is the second most common cause of cancer-specific deaths in the U.S. Unfortunately, the underlying molecular mechanisms for its development and progression remain unclear. Studies have established that microRNAs (miRN...