An Apigenin-Based Bone-Targeted System Enhances Antioxidant Capacity of Bone Marrow Mesenchymal Stem Cells via the PI3K/Akt Pathway to Alleviate Osteoporosis [0.03%]
一种基于芹菜素的骨靶向系统通过PI3K/Akt途径增强骨髓间充质干细胞抗氧化能力以缓解骨质疏松症
Daihui Liu,Yi Wang,Can Zhu et al.
Daihui Liu et al.
The primary etiology of osteoporosis (OP) is the imbalance of bone homeostasis, which is characterized by insufficient formation and excessive resorption. Current clinical drugs for osteoporosis often cause off-target toxicity due to their ...
Green Functionalization of Chitosan via Multicomponent Reactions: Unlocking New Horizons in Biomedical Materials [0.03%]
基于多组分反应的壳聚糖绿色衍生化：生物医药材料的新机遇
Alaleh Omidi,Seyedeh Rozhan Mousavi,Mohammad Taghi Nazeri et al.
Alaleh Omidi et al.
This review presents recent progress in the functionalization of chitosan (Cs) through multicomponent reactions (MCRs) as a promising route for creating innovative biofunctional materials for biomedical applications. Owing to its inherent b...
Mechanical and Electrochemical Corrosion Behavior of Porous Ti-10Zr-xNb Alloys Processed via Powder Metallurgy for Biomedical Implants [0.03%]
用于生物医学植入物的Ti-10Zr-xNb多孔合金的粉末冶金制备及其机械和电化学腐蚀行为研究
Rupesh Kumar,Anshu Raj,Dileep Pathote et al.
Rupesh Kumar et al.
Titanium alloys are widely used for biomedical implants due to their favorable mechanical properties, corrosion resistance, and biocompatibility; however, their high stiffness relative to bone can lead to stress shielding. This study develo...
Intra-articular Methotrexate-Loaded Microsponge as an Adjuvant Strategy for Rheumatoid Arthritis: Localized Treatment with a Systemic Impact [0.03%]
用于 rheumatoid arthritis 的辅助治疗策略的甲氨蝶呤微海绵制剂：局部给药系统ically影响
Patrizia Nadia Hanieh,Noemi Fiaschini,Anna Scotto d&#x;Abusco et al.
Patrizia Nadia Hanieh et al.
Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic synovial inflammation and progressive joint destruction. Methotrexate (MTX) remains the gold standard in RA therapy, yet systemic administration often p...
Tailorable Metal-Polyphenol Nanoparticles for Targeted Treatment of Inflammatory Bowel Disease [0.03%]
用于治疗炎症性肠病的可塑金属-聚酚纳米粒子
Jie Bai,Ying Bao,Shan Li et al.
Jie Bai et al.
Reactive oxygen species (ROS) exert critical influence in inflammatory bowel disease (IBD). Metal-polyphenol nanoparticles (MPNs) have exhibited a promising ability to regulate ROS levels and restore homeostasis in the context of IBD. Howev...
Bioactive and Injectable Granular Hydrogels Incorporating Decellularized Extracellular Matrix [0.03%]
负载脱细胞基质的生物活性注射型颗粒水凝胶
Daniela Trindade,Nikolas Di Caprio,Ana C Maurício et al.
Daniela Trindade et al.
Decellularized extracellular matrices (dECMs) provide bioactive cues that may be useful for the repair of fibrocartilaginous tissues, such as the temporomandibular joint disc (TMJd), which lacks a natural regenerative capacity. While potent...
Biomaterial Screening Identifies Enhanced Osteogenic and Angiogenic Potential of Mn-Doped Calcium Phosphate Coatings [0.03%]
生物材料筛选识别出 Mn 掺杂钙磷酸盐涂层的增强型成骨和促血管生成潜力
Maria Eischen-Loges,Zeineb Tahmasebi Birgani,Yousra Alaoui Selsouli et al.
Maria Eischen-Loges et al.
Synthetic biomaterials such as calcium phosphate (CaP) ceramics are promising substitutes for autologous bone grafts, as they are easy to produce, cost-effective and closely resemble the mineral component of natural bone. However, their per...
Physiological Mechanical Loading Is Crucial for Chondrogenesis and Cartilage Formation by Human Synovium-Derived Stem Cells Stimulated by Kartogenin [0.03%]
生理机械刺激对Kartogenin诱导人滑膜干细胞软骨分化和形成的必要性研究
Jiawei Li,Yixi Li,Haoran Feng et al.
Jiawei Li et al.
Meniscus injuries, prevalent among osteoarthritis patients, the aging population, and athletes, present ongoing challenges in terms of repair and regeneration. As a result, the tissue-engineered meniscus (TEM) has become a prominent focus i...
Catecholamine-Derived Surface Chemistry Regulates Cell-Type-Specific Adhesion and Migration in Uterine Cells [0.03%]
儿茶酚胺衍生的表面化学调节子宫细胞类型的特异性黏附和迁移
Alexander J Steeves,Fabio Variola
Alexander J Steeves
Effective healing of the uterine wall after surgical or pathological injury remains a major clinical challenge that can impair fertility and quality of life. Bioadhesive polymers derived from catecholamines offer a promising platform for ut...
Covalent Surface Modification by Amino Acid Derivatives Improved the Surface Thromboresistance in Glutaraldehyde-Processed Bovine Pericardium for Use as a Heart Valve Leaflet [0.03%]
戊二醛处理的牛心包材表面用氨基酸衍生物进行共价修饰可提高其抗凝血性能以用于心脏瓣膜修复或替换手术
Devika S L,Jesna Puthiya Veettil,Sagar Jawla et al.
Devika S L et al.
Subclinical leaflet thrombosis is a major cause of failure in both surgical and transcatheter bioprosthetic heart valves. Thromboresistance is a basic prerequisite for a cardiovascular biomaterial. In this study, bovine pericardium (BP) was...