Architectural Tuning of Ruthenium Centers to Drive Mitochondria-Mediated Apoptosis in Melanoma Cells [0.03%]
钌中心的架构调整可诱导黑色素瘤细胞线粒体介导的凋亡
Rakesh Kumar Rai,Kalyani Eswar,Girbide Amitkumar Ramakant et al.
Rakesh Kumar Rai et al.
New Ru(II) arene complexes, namely, Bis(η6-p-cymene)-3,3'-((2,4,6-trimethyl-1,3-phenylene)bis(methylene))bis(1-(pyridin-2-ylmethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-thione)(dichloro)ruthenium(II) dichloride (Ru-BIS) and 1-isopropyl-3-(pyr...
The Stiffness of Bone Extracellular Matrix Derived Scaffolds Regulates Macrophage Function and Osteogenesis of Mesenchymal Stromal Cells [0.03%]
骨基质衍生支架的刚度调节巨噬细胞功能和间充质干细胞成骨分化
Giovanni Gonnella,Sinead A O&#x;Rourke,Aisling Dunne et al.
Giovanni Gonnella et al.
Bone extracellular matrix (ECM) derived biomaterials possess intrinsic osteoinductive properties, motivating their use as scaffolds for bone and osteochondral defect repair. However, their translation is limited by the need for scalable and...
Three-Dimensional Printing of Polycaprolactone Scaffolds with Multiscale Porosity for Bone Tissue Engineering [0.03%]
具有多尺度孔隙率的聚己内酯骨组织工程支架的三维打印技术
Mikaela Kutrolli,Noah S Pereira,Delaram Ghanbariamin et al.
Mikaela Kutrolli et al.
Extrusion-based three-dimensional printing enables the fabrication of patient-specific scaffolds. Polycaprolactone (PCL)-based scaffolds have been widely used for the treatment of bone defects. However, extruded filaments are typically nonp...
A Dual-Crosslinked Collagen/Hyaluronic Acid/Chitosan Hydrogel for Integrated Hemostasis and Infected Wound Healing [0.03%]
一种双重交联的胶原蛋白/透明质酸/壳聚糖水凝胶，用于综合止血和感染伤口愈合
Sheji Weng,Zhongqin Lin,Kai Tan et al.
Sheji Weng et al.
Conventional wound dressings often fail to integrate rapid hemostasis, antibacterial protection, and a pro-regenerative microenvironment, leading to persistent infection and delayed healing in complex wounds. Herein, we report a multifuncti...
Electrospun Nanofiber Dressings for Diabetic Wounds: From Single-Layer to Intelligent Composite Systems [0.03%]
用于糖尿病伤口的静电纺纳米纤维敷料：从单层到智能复合系统
Yuqing Dong,Wenbo Wu,Xinyu Li et al.
Yuqing Dong et al.
Diabetic chronic wounds have become a major challenge for clinical treatment due to their complex pathological microenvironment, including persistent inflammatory response, angiogenesis disorder, excessive oxidative stress, and susceptible ...
Mechanical Response and Damage Evolution of PMMA-Based Bone Cement from Compressive Calibration to Shear Prediction [0.03%]
聚甲基丙烯酸甲酯骨水泥的压缩标定及剪切预测下的力学响应与损伤演化规律研究
Huanli Qi,Yinwang Zhang,Zhen Xu et al.
Huanli Qi et al.
In this study, a three-dimensional viscoelastic lattice spring model (VLSM) is employed to evaluate the transferability of compression-calibrated material parameters to shear loading for poly(methyl methacrylate) (PMMA)-based bone cement (B...
Structure-Guided CDR3 Insertion Enables Affinity Maturation of Naive Single-Domain Antibodies against Small-Molecule Haptens [0.03%]
结构指导的CDR3插入使 naive 型单域抗体的小分子半抗原亲和力成熟成为可能
Zenglin Yang,Guoqiang Li,Yuanyuan Ge et al.
Zenglin Yang et al.
Single-domain antibodies (sdAbs) derived from naive phage display libraries offer a time-efficient alternative to animal immunization but often exhibit suboptimal affinity, particularly for small-molecule haptens, where restricted binding i...
ROS-Responsive, Water-Oil Biphasic Hydrogel-Based Separable Microneedle System for Intra-Articular Delivery in Osteoarthritis Therapy [0.03%]
响应ROS的水油双相性水凝胶基可分离microneedle系统，用于骨关节炎治疗的关节内输送
Xian Zhang,Na Li,ChengRong Zhang et al.
Xian Zhang et al.
Osteoarthritis (OA) is characterized by a chronic inflammatory microenvironment with excessive reactive oxygen species (ROS) and progressive cartilage degeneration. To address these challenges, we developed a ROS-responsive, water-oil bipha...
Photocurable Allyl-Succinylated Collagen Bioink for High-Resolution 3D Bioprinting and Regenerative Diabetic Wound Healing [0.03%]
用于高分辨率3D生物打印和再生糖尿病伤口愈合的光固化烯丙基琥珀酰明胶生物墨水
Mingzhu Ye,Guoqi Cui,Ziheng Zhu et al.
Mingzhu Ye et al.
Three-dimensional (3D) bioprinting of collagen-based hydrogels remains limited by poor solubility, weak mechanics, and slow photocrosslinking, which hinder print fidelity and restrict clinical translation. Here, we report a photocurable all...
Microfluidic Engineered Gelatin Methacryloyl Microsphere Scaffolds Loaded with Extracellular Vesicles Derived from Mesenchymal Stromal Cells Promote Functional Recovery in Rats with Spinal Cord Injury [0.03%]
载有间充质基质细胞源外泌体的微流控工程明胶甲基丙烯酰微球支架促进脊髓损伤大鼠的功能恢复
Haoyu Sheng,Yihe Wang,Yijing Zhao et al.
Haoyu Sheng et al.
Spinal cord injury (SCI) leads to significant locomotor, sensory, and autonomic deficits and remains refractory to current therapies. Extracellular vesicles from mesenchymal stromal cells (MSC-EVs) are potential acellular therapeutic strate...