Daniela Isaacs-Bernal,Noor E Bahsoun,Lia Huo et al.
Daniela Isaacs-Bernal et al.
Affinity-controlled release provides a versatile approach for the delivery of proteins from hydrogel systems by harnessing noncovalent interactions between a molecule of interest and a binding ligand. We present a strategy for the controlle...
Electric Field-Guided Biomimetic Mineralization of Enamel via Interfacial Engineering of Nanostructured HAp/PDA Coatings with Anisotropy and Enhanced Hardness [0.03%]
基于界面工程各向异性增强硬度的纳米结构HAp/PDA涂层引导仿生牙釉质矿化
Pavel Seredin,Dmitry Goloshchapov,Tatiana Litvinova et al.
Pavel Seredin et al.
Human enamel is a hierarchically organized hydroxyapatite biomineral, but it lacks regenerative capacity, motivating interfacial engineering strategies that control mineral growth at the enamel surface. This work examines an electric-field-...
AAV9-Mimetic Peptides and Electroporation Synergistically Enhance Nanoparticle Transport through the Blood-Brain Barrier [0.03%]
AAV9拟肽和电穿孔协同增强纳米颗粒通过血脑屏障运输
Nina Butkovich,Yifei Xu,Yuchen Song et al.
Nina Butkovich et al.
Crossing the blood-brain barrier (BBB) remains a major hurdle in neurotherapeutics delivery. However, adeno-associated virus serotype 9 (AAV9) variants can cross from the bloodstream to accumulate in brain tissue, with their tropism facilit...
Dual Biomolecule Patterning on Micropatterned Polylactide Surfaces Bearing Oppositely Charged Polymer Brushes at Neighboring Sites [0.03%]
基于邻位携带相反电荷聚合物刷的微图案聚乳酸表面的双分子阵列图案化技术
Meenakshi Verma,Zhaowei Jiang,Anita Shukla et al.
Meenakshi Verma et al.
Suitably functionalized polymer brush-modified micropatterned surfaces may enable precise control over interfacial interactions with multiple biomolecules, potentially leading to the creation of proteins/DNA microarrays, biosensors, diagnos...
Silk Fibroin-Based Hemostatic Sealant with Robust Wet Adhesion and High Burst Pressure Resistance for Arterial Bleeding Control [0.03%]
一种用于动脉止血且具有强力湿粘附和高爆破压抵抗力的丝素蛋白基血液密封剂
Yanqiu Leng,Qing Li,Kun Yu et al.
Yanqiu Leng et al.
High-pressure arterial bleeding is a life-threatening condition that can rapidly lead to hemorrhagic shock or death. However, effective noncompressive hemostatic strategies for managing such bleeding remain a significant clinical challenge....
Therapeutic Potential of Mn- and Ce-Doped Bioactive Glass-Eggshell Membrane Composites in Critical Skin Wound Repair [0.03%]
掺锰和掺铈生物活性玻璃-蛋膜复合材料在难治性皮肤伤口修复中的治疗潜力
Pratik Das,Tuhin Sarkar,Bhavana Narayana Swamy et al.
Pratik Das et al.
The fabrication and use of sustainable and biocompatible wound-healing materials represent a newer approach to wound regeneration. An eggshell membrane (ESM), a naturally derived biomaterial, has a thin but permeable structure, making it su...
Three-Dimensional-Printed Gelatin Methacrylate/Hydroxyapatite/Barium Titanate Piezoelectric Hydrogels for Bone Tissue Engineering [0.03%]
用于骨组织工程的三维打印压电明胶甲基丙烯酸盐/羟基磷灰石/钛酸钡水凝胶
Yunfeng Zhao,Meng Li,Yifei Zhang et al.
Yunfeng Zhao et al.
Bone defect repair remains a major clinical challenge. This study presents a novel strategy using a 3D-printed piezoelectric hydrogel scaffold─composed of gelatin methacrylate (GelMA, Gel), hydroxyapatite (HA), and barium titanate (BTO)─f...
Corrosion and Wear Properties of Low-Modulus TiZrNb-Based Complex Concentrated Alloys under Simulated Physiological Conditions [0.03%]
低模量TiZrNb基复合集中合金在模拟生理条件下的腐蚀和磨损性能研究
Nanda Kishore Karnam,Ravishankar Suman,Srikant Gollapudi et al.
Nanda Kishore Karnam et al.
Titanium (Ti) and its alloys have evolved through multiple generations to possess enhanced biomedical performance. However, challenges such as stress shielding, low yield strength, and inadequate corrosion resistance persist in conventional...
Hesperidin-Loaded Nanoparticles Attenuate Pathological Angiogenesis in Oxygen-Induced Retinopathy by Modulating the Retinal Immune Microenvironment [0.03%]
芸香素纳米粒通过调节视网膜免疫微环境抑制氧诱导视网膜病变小鼠病理性血管生成
Minglan Wang,Menglei Wang,Changhao Dong et al.
Minglan Wang et al.
Retinal neovascularization is closely linked to retinal inflammation. Microglia, the resident immune cells of the retina and the primary responders to inflammatory stimuli, play a central role in pathological retinal vascular remodeling, in...
Engineering Dynamic Hydrogels via GelMa-AlgMa Hybrids for Enhanced Swelling, Porosity, and Tissue Mimicry [0.03%]
通过明胶甲基丙烯酸(GelMa)和藻酸盐甲基丙烯酸(AlgMa)的杂化制备工程动态水凝胶以增强溶胀性、多孔性和组织模拟性
Claudia Benito Alston,Madelyn Grace Chadwick,Saaniya Eman Rupani et al.
Claudia Benito Alston et al.
Hydrogels have gained prominence in biomedical applications, including drug design, tissue engineering, and wound dressing, due to their versatile properties. In this study, we investigated the mechanical and biological properties of a phot...