Modulating Surface Properties and Osteoblast Responses in Bone Regeneration via Positive and Negative Charges during Electrospinning of Poly(l-lactide- co-ε-caprolactone) (PLCL) Scaffolds [0.03%]
Katarzyna Marszalik,Martyna Polak,Krzysztof Berniak et al.
Katarzyna Marszalik et al.
The global demand for faster and more effective bone regeneration calls for biomimetic scaffolds that actively guide cell behavior beyond providing structural support. Electrospinning offers unique opportunities to tailor scaffold propertie...
Amin Orash Mahmoudsalehi,Kevin Stalin Catzim Rios,Wendy Ortega-Lara et al.
Amin Orash Mahmoudsalehi et al.
Corneal transplantation is the gold-standard treatment for end-stage corneal disease. However, its clinical use is limited by the global shortage of donor tissue, risks of immune rejection, and postoperative complications. Corneal tissue en...
Rigidity Sensing of Inclusions Directs Differentiated Cell Elongation and Force Generation across Phenotypes [0.03%]
Yuxin Luo,Yimin Luo
Yuxin Luo
Fibrosis is driven in part by the transition of healthy fibroblasts to a contractile phenotype called myofibroblasts. The mechanics of the extracellular matrix play a crucial role in regulating cell fates and behaviors during this transitio...
Biophysical Insights into the Effects of Alkyl Glucoside Surfactant Structural Characteristics on Antigen Stability under Thermal and Mechanical Stress [0.03%]
烷基糖苷表面活性剂结构特征对其在热力和机械应力下抗原稳定性影响的生物物理见解
Wenqi Yang,Ge Yu,Huiyang Wang et al.
Wenqi Yang et al.
The stability of protein antigens during production, storage, and transportation is critical for determining the effectiveness and safety of vaccines. However, protein antigens are susceptible to thermal and mechanical stresses, which can l...
In Vitro Analysis of Microneedle Patches for Transdermal Drug Delivery: A Minimally Invasive Route to Systemic Circulation [0.03%]
体外微针贴片透皮给药分析：微创进入全身循环的新途径
Haylee L Wagner,Tailynn Y McCarty,Theeraphop Prachyathipsakul et al.
Haylee L Wagner et al.
Nanoparticles offer great potential as drug delivery vehicles but conveniently administering them systemically at therapeutically relevant doses remains a challenge. To date, systemic delivery of nanoparticles is achieved through intravenou...
Development of High-Flexural-Strength Titanium/Hydroxyapatite Biocomposites via Cold Spray Deposition with Titanium and Niobium Bond Coats [0.03%]
基于冷喷涂技术的Ti/Nb复合底层钛/羟基磷灰石高挠性生物复合材料的研发
Fatemeh Andami,Prateek,Eric Chia et al.
Fatemeh Andami et al.
Achieving rapid, scalable fabrication of bone implants with a high flexural strength remains a major challenge. The persistent issues are mainly attributed to the incompatibility of the biomaterials (e.g., titanium (Ti) and niobium (Nb)) wi...
Rat Spine Fusion Models for Preclinical Research: Opportunities and Challenges [0.03%]
脊髓研究的啮齿动物融合模型：机会与挑战
Antonio Lobao,Samuel W Rice,James Chapman et al.
Antonio Lobao et al.
Rodent models have gained popularity for assessing the efficacy and safety of experimental spine fusion methods in preclinical research, but variability in surgical technique, graft materials, and outcome assessment has limited standardizat...
In Situ Development of Quercetin-Enhanced Layered Double Hydroxides for Targeted Osteosarcoma Therapy [0.03%]
原位生成檞皮素增强型层状双氢氧化物用于靶向治疗骨肉瘤
Panagiota Zygouri,Grigorios Tsiodoulos,Marilena Lianou et al.
Panagiota Zygouri et al.
In this study, we investigated the structural, thermal, and cytotoxic properties of Mg-Al layered double hydroxides (LDHs) intercalated with quercetin. Fourier transform infrared (FTIR) and Raman spectroscopy confirmed the successful incorp...
Exosomes from rADSCs Stress-Preconditioned by Pathological Tissue Homogenate for Diabetic Wound Treatment [0.03%]
病理组织匀浆诱导的rADSCs外泌体促进糖尿病难愈合创面修复
Chuan Chen,Zhou Zhang,Mengjie Xu et al.
Chuan Chen et al.
Diabetic wound healing is severely impaired by a pathological microenvironment, characterized by hyperinflammation, impaired angiogenesis, and disrupted ECM remodeling. Exosomes exhibit great potential for diabetic wound treatment, but the ...
3D/3.5D Extrusion-Printed Electroconductive Carbon-Nanofiber-Embedded Alginate-Gelatin Hydrogel-Based Grafts: Comprehensive Understanding of Process Science and Biocompatibility [0.03%]
基于藻酸盐-胶原蛋白凝胶的嵌入碳纳米纤维的导电性电挤出移植基底：工艺科学和生物相容性的综合研究
Sulob Roy Chowdhury,Krittika Dey,Bikramjit Basu
Sulob Roy Chowdhury
The reconstruction of complex soft tissues, such as urethral and nerve tissues, requires constructs that integrate vascularization, lumen integrity, and innervation with clinically relevant mechanical and biophysical properties. Current tis...