Camille Gontier,Laura Drouvé,Johannes Striebel et al.
Camille Gontier et al.
Electrophysiological experiments have shown that neuronal activity changes upon exposure to altered gravity. More specifically, neurons' firing rates increase during microgravity and decrease during centrifugal-induced hypergravity. Differe...
Boundary cap neural crest stem cells exhibit remarkable resilience to environmental stressors associated with International Space Station mission [0.03%]
边界帽神经 crest 干细胞表现出对国际空间站任务相关环境压力的独特抗逆性
Robert Fredriksson,Yilin Han,Xiangyi Du et al.
Robert Fredriksson et al.
Boundary cap neural crest stem cells (BCs) previously demonstrated resilience during short-term microgravity exposure. In this study, BCs were sent to the International Space Station aboard Axiom Mission 3. Owing to launch regulations and w...
Extreme environment provides clues about socio-environmental stressors contribution to ISS-induced changes in antibody repertoire [0.03%]
极端环境提供了关于社会环境压力源对国际空间站诱导的抗体谱系变化所做贡献的线索
Pauline Jacob,Anne Vanet,Matthias Feuerecker et al.
Pauline Jacob et al.
Spaceflight-induced immune system dysregulation coupled with limited clinical care represents a risk for crew members. This study aimed to discern which stressor encountered during a space mission impact the antibody repertoire. Via next-ge...
Persistent cognitive impairment and bone health following helium ion exposure: implications for space travel [0.03%]
氦离子辐射引起的空间辐射危害：对认知和骨骼健康的潜在长期影响
Laura C Bowman,Carli J Burns,Victoria E Elliott et al.
Laura C Bowman et al.
This study investigated the long-term neurobehavioral and physiological impacts of low-dose helium (4He) ion exposure-a key component of galactic cosmic radiation-on male Long Evans rats. After training on the rodent psychomotor vigilance t...
Space travel does not significantly impact cardiac sarcomere function but does induce immune-related proteomic changes [0.03%]
空间旅行不会显著影响心脏肌节功能，但会诱发免疫相关的蛋白质组变化
Henry M Gong,Christine E Delligatti,Hana K Pak et al.
Henry M Gong et al.
Space exploration is important for scientific discovery, advancing technology, and the long-term survival of humanity. However, the impacts of microgravity and cosmic radiation during space travel on human physiology are not completely unde...
Cardiovascular and central nervous system risk in astronauts: the minipig as a physiologically relevant radiation model [0.03%]
航天员的心血管和中枢神经系统风险：作为生理相关的辐射模型的迷你猪
Diana Cruz-Topete,Gregory Nelson,Marshleen Yadav et al.
Diana Cruz-Topete et al.
Humans will return to the Moon and travel to deep space on their journey to Mars. Space exploration presents significant hazards to human health, including exposure to ionizing radiation (IR) from galactic cosmic rays (GCR) and solar partic...
Ground-based microgravity simulators for plant research: principles and biological responses [0.03%]
基于地面的植物微重力模拟装置及生物学效应研究
Gwanggeun Song,Byoung-Kwan Cho,Geonwoo Kim et al.
Gwanggeun Song et al.
Gravity is a fundamental environmental factor influencing plant evolution and development. As humanity prepares for long-duration space missions, understanding plant responses to microgravity is crucial for sustainable space agriculture. Wh...
Simulated microgravity with physiological shear reveals endothelial disruption in a dual-stimulus bioreactor [0.03%]
基于生理剪切力的仿失重双刺激生物反应器揭示内皮细胞损伤
Nikolaos Pipis,Rachel Garner,Christopher Ludtka et al.
Nikolaos Pipis et al.
Microgravity alters vascular homeostasis by disrupting mechanical cues critical to endothelial function. Here, we report a benchtop bioreactor that integrates simulated microgravity with physiological laminar shear stress ( ~ 3 dyn/cm²) to...
Comprehensive analysis of miRNA expression, secretion profile, and functional network during myogenesis in response to spaceflight [0.03%]
微重力诱导的肌肉萎缩过程中miRNA表达、分泌及功能网络的分析研究
Wenqing Kong,Mei Ma,Zhuoyang Li et al.
Wenqing Kong et al.
MicroRNAs (miRNAs) are key regulators of skeletal muscle development and homeostasis. As secretory factors, previous studies have identified and validated a space flight-associated circulating microRNA (miRNA) signature in response to space...
Decoupling surface topography from gravitational acceleration in cryogenic pool boiling [0.03%]
极低温池沸腾中脱耦表面形貌和重力加速度的影响
Mohammad S Reza,Philip Ignatoff,Jimmy Almacddissi et al.
Mohammad S Reza et al.
Boiling heat transfer is governed by a complex interplay between surface conditions and gravitational acceleration. To isolate the sole effects of gravity, we investigated the pool boiling characteristics of liquid nitrogen on atomically sm...