Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson's disease [0.03%]
α-突触核蛋白原纤维结构对帕金森病实验模型中诱导作用的影响
Junichiro Ohira,Masanori Sawamura,Kenichi Kawano et al.
Junichiro Ohira et al.
The central pathogenesis of Parkinson's disease involves the misfolding and aggregation of α-synuclein (α-syn). There is a widespread belief that α-syn can propagate in a prion-like manner, and α-syn preformed fibrils (PFFs) have been w...
Video analysis reveals early signs of Bradykinesia in REM sleep behavior disorder and Parkinson's disease [0.03%]
视频分析揭示了快速眼动睡眠行为障碍和帕金森病的早期间歇性运动减少迹象
Diego L Guarín,Gabriela Acevedo,Carolina Calonge et al.
Diego L Guarín et al.
Idiopathic REM sleep behavior disorder (iRBD) is a strong predictor of neurodegenerative diseases like Parkinson's disease (PD). Early detection of motor impairments such as bradykinesia is critical for identifying at-risk populations. This...
Effect of high, low, and asymmetric frequency subthalamic stimulation on speech and voice in Parkinson's disease: a randomized trial [0.03%]
高频、低频及不对称频率刺激对帕金森病言语和声音的影响：一项随机对照试验
Zhitong Zeng,Mei Yang,Zhengyu Lin et al.
Zhitong Zeng et al.
While bilateral high-frequency subthalamic nucleus stimulation (Bi-HFS) frequently worsens speech in Parkinson's disease (PD), low-frequency stimulation (LFS) may alleviate gait deficits but lacks robust evidence for speech benefits. This r...
Advancements in invasive and non-invasive neuromodulation for Parkinson's disease: current findings and future directions [0.03%]
帕金森病的有创和无创脑刺激治疗进展：现有研究发现及未来发展方向
Nabin Koirala,Manuel Bange,Aparna Wagle Shukla et al.
Nabin Koirala et al.
A novel approach to detecting plasma synuclein aggregates for Parkinson's disease diagnosis [0.03%]
一种新的检测帕金森病血浆中α-突触核蛋白聚集体的方法
Hyo Rim Ko,Dawon Lee,Hyojung Park et al.
Hyo Rim Ko et al.
Alpha-synuclein (αSyn) aggregates are pathognomonic of Parkinson's disease (PD) and play a critical role in its pathogenesis. However, existing diagnostic approaches rely on invasive cerebrospinal fluid (CSF) sampling or tissue biopsies, l...
Oligomeric alpha-synuclein causes early synaptic dysfunction of the corticostriatal pathway associated with non-motor symptoms [0.03%]
寡聚alpha-突触核蛋白引起皮质纹状体通路早期突触功能障碍与非运动症状相关
Laura Bellingacci,Miriam Sciaccaluga,Alfredo Megaro et al.
Laura Bellingacci et al.
In synucleinopathies, α-synuclein oligomers (OSyn) appear to be associated with neurodegeneration, neurotoxicity, and proinflammatory responses, even at low concentrations, suggesting their pivotal role in the pathogenesis of Parkinson's d...
Diffusion-tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson's disease [0.03%]
帕金森病胆碱能起始侧别的甘霖系统不对称的扩散张量MRI研究
Zihan Li,Xinxin Miao,Qiumei Zhang et al.
Zihan Li et al.
The characteristic asymmetric motor symptoms of Parkinson's disease (PD) may be associated with asymmetric deposition of α-synuclein. The impaired glymphatic system may promote pathological deposition of α-synuclein, leading to disease pr...
Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson's model [0.03%]
表观基因团和转录分析在罗特诺模型帕金森病中的独特黑质和皮层通路
Maria Tsalenchuk,Kyle Farmer,Sandra Castro et al.
Maria Tsalenchuk et al.
Pesticide exposure is increasingly recognized as a potential environmental factor in idiopathic Parkinson's disease, though the molecular mechanisms remain unclear. This study explores how pesticide exposure alters gene regulation in key br...
Identifying individuals at-risk of developing Parkinson's disease using a population-based recruitment strategy: The Healthy Brain Ageing Kassel Study [0.03%]
利用基于人群的招募策略识别帕金森病高风险个体：卡塞尔健康大脑老化研究
Sebastian Schade,Soumyabrata Ghosh,Alicia Garrido et al.
Sebastian Schade et al.
Neurodegeneration in Parkinson's disease (PD) occurs before motor features develop: assessing risk factors and identifying prodromal markers is necessary to recruit prodromal cohorts, improve early diagnosis, and develop preventive therapie...
Functional network differences between unilateral and bilateral deep brain stimulation of the subthalamic nucleus [0.03%]
丘脑底核电刺激的单侧与双侧差异性功能网络分析
Brendan Santyr,Alexandre Boutet,Mohamad Abbass et al.
Brendan Santyr et al.
Unilateral versus bilateral implantation is a critical surgical consideration for deep brain stimulation in Parkinson's disease; however, the differing therapeutic effects remain incompletely understood. Using functional magnetic resonance ...