Support vector machine-driven Parkinson's disease identification: a 7-Tesla multidimensional structural MRI approach [0.03%]
Yongqin Xiong,Zhixuan Li,Mingliang Yang et al.
Yongqin Xiong et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder diagnosed clinically by cardinal motor symptoms, with structural brain changes associated with its diverse motor and non-motor manifestations. This study integrated multid...
Differentiating tremor-dominant parkinson's disease from essential tremor using neuromelanin- sensitive imaging and T1w/T2w ratio [0.03%]
Yuelin Fang,Cheng Zhou,Bingting Zhu et al.
Yuelin Fang et al.
Parkinson's disease (PD) and essential tremor (ET) are the most common movement disorders and share tremor symptom. This study aimed to differentiate tremor-dominant PD (TD-PD) from ET using neuromelanin-sensitive MRI (NM-MRI) and T1w/T2w r...
Brendan Santyr,Aaron Loh,Jürgen Germann et al.
Brendan Santyr et al.
The network changes elicited by deep brain stimulation (DBS) in Parkinson's disease (PD) remain incompletely understood. We used functional MRI (fMRI) during active stimulation of the subthalamic nucleus (STN) to identify brain networks ass...
Elevated levels of colonic interleukin-1beta and interleukin-8 in isolated REM sleep behavior disorder without associated changes in permeability [0.03%]
Loïc Sellier Montaigne,Simon Lassozé,Adrien de Guilhem de Lataillade et al.
Loïc Sellier Montaigne et al.
Gastrointestinal inflammation could contribute to the early development of Parkinson's disease (PD). This study investigated gut inflammation, intestinal barrier function, and integrity in patients with isolated REM sleep behavior disorder ...
Frequency-based deep learning to identify subtle postural instability in early, untreated Parkinson's disease [0.03%]
David Engel,Pablo Burgos,Patricia Carlson-Kuhta et al.
David Engel et al.
Despite evidence of early neurodegeneration, postural instability is commonly associated with later stages of Parkinson's disease (PD), mainly due to a lack of sensitive measures. Here, we aim to provide a sensitive, easily obtainable objec...
Probiotic supplementation for anxiety symptoms in people with Parkinson's disease: a randomized, double-blind, placebo-controlled trial [0.03%]
Joyce S T Lam,Kira N Tosefsky,Nicholas J Ainsworth et al.
Joyce S T Lam et al.
Anxiety is a prevalent non-motor symptom of Parkinson's disease (PD), yet treatment options remain limited. This randomized, double-blind, placebo-controlled trial evaluated the effects of a 12-week probiotic supplement containing nine bact...
Plasma proteomics for Parkinson's disease classification: cross-cohort benchmarking of proteomic, transcriptomic, and multimodal models [0.03%]
Nicholas Minster,Saleet Jafri
Nicholas Minster
Blood-based biomarkers could facilitate early detection and severity monitoring for Parkinson's disease (PD), yet the relative diagnostic utility of proteomic versus transcriptomic signals and the added value of multimodal integration under...
Disruption of the LRRK2 substrate RAB12 facilitates neurotransmission and causes hyperactivity in mice [0.03%]
Xingjian Li,Yuanxin Chen,Huaixing Wang et al.
Xingjian Li et al.
RAB12 is a small GTPase and a validated substrate of LRRK2, a kinase genetically linked to Parkinson's disease (PD). While RAB12-LRRK2 signaling has been implicated in ciliogenesis and immune regulation, the neuronal function of RAB12 remai...
Personalized metabolite biomarker predictions reveal heterogeneous characteristics of Parkinson's disease [0.03%]
个性化代谢标志物预测揭示帕金森病的异质性特征
Ecehan Abdik,Tunahan Çakır
Ecehan Abdik
Understanding the heterogeneous nature of Parkinson's disease is crucial for improving diagnostic and treatment strategies that benefit distinct patient subgroups. Genome-scale metabolic models (GEMs) comprising biochemical reactions and co...
StimVision: smartphone video kinematics to optimize DBS programming in Parkinson's disease [0.03%]
基于智能手机的视频运动分析用于帕金森病脑深部电刺激编程优化
Florian Lange,Philipp Köberle,Gamze Adaçay et al.
Florian Lange et al.
Deep brain stimulation (DBS) improves motor function in Parkinson's disease, yet programming remains labor-intensive and largely subjective. We evaluated a smartphone video-based kinematic framework (StimVision) for objective, within-sessio...