Altered light-dark phase-dependent behavioral responses and suprachiasmatic nucleus pathology in an α-synuclein rat model of Parkinson's disease [0.03%]
α-突触核蛋白帕金森病大鼠模型中光线明暗相位依赖性行为反应的改变及视交叉上核病理变化
Hanna Weber,Meike Statz,Nicolas Casadei et al.
Hanna Weber et al.
Disruption of circadian rhythms is a key feature of neurodegenerative diseases and a non-motor feature of Parkinson's disease, which significantly impairs health-related quality of life; yet, the underlying mechanisms are only partially und...
Auditory cueing modulates motor performance and brain activity in early Parkinson's disease-a kinematic and fMRI study [0.03%]
听觉提示可调节早期帕金森病患者的运动表现及大脑活动--一项关于运动学和fMRI的研究
Andrea Gardoni,Elisabetta Sarasso,Marco Forghieri et al.
Andrea Gardoni et al.
Cues are specific references that support motor performance by improving speed, timing, and amplitude while reducing variability. This study aimed at investigating the effects of external auditory cueing on bradykinesia-related kinematic de...
Discovery of lipid biomarkers for idiopathic Parkinson's disease in red blood cells and plasma [0.03%]
血红细胞和血浆中帕金森病脂质生物标志物的发现
Shaima Muhammed Nazaar,Anne M Roberts,Malcolm Horne et al.
Shaima Muhammed Nazaar et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss and lipid-rich Lewy bodies containing misfolded alpha-synuclein, implicating lipid dysregulation in pathogenesis. We performed comprehensive ...
DBSsync: combining intracranial and multimodal data to investigate new biomarkers in Parkinson's disease [0.03%]
DBSsync：结合颅内和多模态数据以研究帕金森病的新生物标志物
Juliette Vivien,Charlotte E Stensholt,Lucie Hortmann et al.
Juliette Vivien et al.
Implanted deep brain stimulation devices are now capable of chronically recording activity from intracranial brain areas during stimulation. This new type of data has the potential to increase our understanding of disease-related brain acti...
Comparative analysis of progression milestones across Parkinson's disease clinical, pathological, and data-driven subtypes: a 10-year follow-up [0.03%]
帕金森病临床、病理和数据驱动亚型进展里程的比较分析：为期十年的随访研究
Ahmed Negida,Nitai Mukhopadhyay,Brian D Berman et al.
Ahmed Negida et al.
Parkinson's disease (PD) heterogeneity complicates disease-modification clinical trial design and lead to ambiguous results, necessitating robust subtyping frameworks to identify rapid progressors. This study compared progression milestones...
Reactive astrocytes mediate toxicity in iPSC derived dopaminergic neurons [0.03%]
诱导多能干细胞来源的多巴胺能神经元中的星形胶质细胞介导的毒性反应
Naroa Ibarra-Aizpurua,Jon Olano-Bringas,Benjamin Vallin et al.
Naroa Ibarra-Aizpurua et al.
Neuroinflammation is a hallmark of Parkinson's disease (PD), a progressive neurodegenerative disorder characterized by the accumulation of α-synuclein and the death of dopaminergic neurons in the substantia nigra. Mutations in GBA are a co...
Associations of DTI-ALPS index and choroid plexus volume with clinical severity across the Parkinson's disease spectrum [0.03%]
Parkinson病谱不同临床阶段DTI-ALPS指数及脉络丛体积变化的关联性研究
Yujue Wang,Zixuan Lin,Dan Wu et al.
Yujue Wang et al.
Impaired clearance of pathogenic proteins may contribute to Parkinson's disease (PD) progression, but the clinical relevance of brain clearance-associated processes in humans remains incompletely understood. Using cross-sectional data from ...
Denoised MDS-UPDRS part-III scores yield new patterns of progression heterogeneity in early stage Parkinson's disease [0.03%]
降噪的MDS-UPDRS第Ⅲ部分评分可揭示帕金森病早期阶段进展异质性的新模式
Jonathan D Koss,Sule Tinaz,Hemant D Tagare
Jonathan D Koss
Parkinson's Disease (PD) Motor Scores (MDS-UPDRS Part III) are quite noisy. This paper proposes a new methodology for processing these scores by first denoising the scores to enhance the underlying progression signal, and then conducting a ...
The degenerome-a novel streamline-wise approach for white matter integrity in neurodegeneration [0.03%]
脑退行性疾病中白质完整性的新型分析方法-损伤基因组学法
Jonas A Hosp,Marco Reisert,Nils Schröter et al.
Jonas A Hosp et al.
Neurodegenerative diseases impair both gray matter and long-range white-matter pathways. Existing diffusion MRI approaches are either local or depend on predefined parcellations, limiting their ability to capture distributed network disrupt...
Spatial multi-omics reveals region-specific molecular signatures in a 6-OHDA model of Parkinson's disease [0.03%]
空间多组学揭示6-OHDA帕金森病模型中区域特异性分子标志物
Sun Young Lee,Hyun Kyong Shon,Amos Chungwon Lee et al.
Sun Young Lee et al.
Parkinson's disease (PD) is characterized by complex molecular and circuit-level alterations that extend beyond dopaminergic neurodegeneration, yet the spatial integration of metabolic and proteomic changes remains insufficiently explored. ...