Towards scalable screening for the early detection of Parkinson's disease: validation of an iPad-based eye movement assessment system against a clinical-grade eye tracker [0.03%]
一种基于iPad的眼动检测系统在帕金森病早期筛查中的有效性研究：与临床专用眼动仪的对比研究
Jamie Koerner,Erin Zou,Jessica A Karl et al.
Jamie Koerner et al.
Early detection and monitoring of Parkinson's disease (PD) remain challenging, highlighting the need for accessible, cost-effective tools. Saccadic eye movement abnormalities are promising noninvasive biomarkers for PD screening and monitor...
Online prediction of optimal deep brain stimulation contacts from local field potentials in Parkinson's disease [0.03%]
基于局部场电位的帕金森病最佳深部脑刺激触点的在线预测
Marjolein Muller,Stefano Scafa,Ibrahem Hanafi et al.
Marjolein Muller et al.
Selecting optimal contacts for chronic deep-brain stimulation (DBS) requires a monopolar review, involving time-consuming manual testing by trained personnel, often causing patient discomfort. Neural biomarkers, such as local field potentia...
Phosphorylated α-synuclein in CSF and plasma does not reflect synucleinopathy [0.03%]
磷酸化α-突触核蛋白的脑脊液和血浆检测不能反映路易小体疾病病理特征
Giovanni Bellomo,Erik Stoops,Jeroen Vanbrabant et al.
Giovanni Bellomo et al.
We developed a highly sensitive and specific single-molecule array (Simoa) Homebrew assay for quantification of phosphorylated α-synuclein at serine 129 (pS129 α-syn) and evaluated its performance in human cerebrospinal fluid (CSF) and pl...
Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinson's Disease [0.03%]
采用果蝇帕金森病模型研究多胺相互转换酶的调节对α-突触核蛋白水平和毒性的影响
Bedri Ranxhi,Zoya R Bangash,Zachary M Chbihi et al.
Bedri Ranxhi et al.
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by α-synuclein accumulation and aggregation, leading to disrupted cellular homeostasis, impaired mitochondrial function, and neuroinflammation, ultimately causing neuro...
Enhanced beta power emerges from simulated parkinsonian primary motor cortex [0.03%]
模拟帕金森病原发性运动皮层增强的beta频段功率
Donald W Doherty,Liqiang Chen,Yoland Smith et al.
Donald W Doherty et al.
Primary motor cortex (M1) layer 5B pyramidal tract (PT5B) neurons develop intrinsic pathology in rodent and primate Parkinson's disease (PD) models. We used computer simulation to predict how decreased PT5B neuron excitability, identified w...
GABA outperforms iron and neuromelanin in detecting nigrostriatal alterations in early-stage Parkinson's disease with RBD [0.03%]
在早期具有快速眼动睡眠行为障碍的帕金森病中，GABA胜过铁和神经黑素检测黒质纹状体通路异常
Youmin Zhang,Pei Huang,Peng Liu et al.
Youmin Zhang et al.
This study aimed to examine variations in iron deposition, neuromelanin (NM) content, gamma-aminobutyric acid (GABA) and glutamate-glutamine complex (Glx) levels within the nigrostriatal pathway in early-stage Parkinson's disease (PD) patie...
Elevated plasma levels of alpha-synuclein are dispensable for Parkinson's disease pathology [0.03%]
Parkinson病病理无需α-突触核蛋白升高 Plasma水平即可
Jin-Young Jeong,Namsuk Kim,Yan Li et al.
Jin-Young Jeong et al.
Although α-synuclein levels are elevated in the blood plasma of Parkinson's disease (PD) patients, it remains unclear whether blood-derived α-synuclein directly contributes to PD. To investigate this, we developed a novel mouse model in w...
Classification of GBA1 variants and their impact on Parkinson's disease: an in silico score analysis [0.03%]
GBA1变异的分类及其对帕金森病的影响：一种基于计算机分析的方法
Aymeric Lanore,Christelle Tesson,Aymeric Basset et al.
Aymeric Lanore et al.
Bi-allelic pathogenic GBA1 variants cause Gaucher disease (GD), whereas certain heterozygous missense variants increase the risk of Parkinson's disease (PD), although the underlying mechanisms are unclear. Here, we classified GBA1 missense ...
Position paper: leveraging non-human primate (NHP) specificities to accelerate Parkinson's disease and ageing research [0.03%]
position paper:利用非人灵长类动物的特有性加速帕金森病和衰老研究
Erwan Bezard,Rozalyn M Anderson,Romina Aron Badin et al.
Erwan Bezard et al.
The PD-AGE international task force underscores the pivotal role that non-human primate (NHP) models play in advancing our understanding of Parkinson's disease (PD) and ageing. Due to their close genetic, anatomical, and behavioural similar...
Large-scale copy number variant analysis in genes linked to Parkinson´s disease [0.03%]
与帕金森病相关的基因的大规模拷贝数变异分析
Zied Landoulsi,Katja Lohmann,Eva-Juliane Vollstedt et al.
Zied Landoulsi et al.
Genetic studies of Parkinson's disease (PD) have focused on single nucleotide variants (SNVs), with limited attention to copy number variants (CNVs). This study investigates CNVs in PD using candidate PD-related genes and genome-wide approa...