MacKenzie L Bolen,Kelly B Menees,Aidan C Dupreez et al.
MacKenzie L Bolen et al.
The heterogeneous prodromal phase of Parkinson's disease (PD) has made identifying catalysts that drive disease progression critical for effective development of disease-modifying therapies. Recently, the role of gastrointestinal dysfunctio...
Increased frontal [123I]FP-CIT binding in Parkinson's disease patients with self-reported REM sleep behavior disorder [0.03%]
帕金森病患者中特发性快速眼球运动睡眠行为障碍的正电子发射断层扫描研究
Elina Jaakkola,Jani Ijas,Juho Joutsa et al.
Elina Jaakkola et al.
Rapid eye movement (REM) sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson's disease (PD) and a potential early marker of synucleinopathy-related neurodegeneration. While striatal dopaminergic dysfunction in PD-RBD ...
Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts [0.03%]
甘油三酯-葡萄糖指数可预测两组帕金森病患者的认知衰退和纹状体多巴胺缺乏
Huimin Cao,Yuying Zhao,Ziyi Chen et al.
Huimin Cao et al.
Heterogeneity is an important feature of cognitive impairment in patients with Parkinson's disease (PD), with emerging evidence linking insulin resistance to accelerated cognitive decline. Our investigation examined the relationship between...
Author Correction: Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson's disease trials [0.03%]
作者更正：时间事件分析可减轻症状治疗对帕金森病临床试验疗效的影响
Gennaro Pagano,Dylan Trundell,Tanya Simuni et al.
Gennaro Pagano et al.
Published Erratum
NPJ Parkinson's disease. 2025 Aug 13;11(1):241. DOI:10.1038/s41531-025-01103-y 2025
Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotype [0.03%]
类似帕金森病小鼠的抑郁表型早期突触变化和大脑连接减少
Lluis Miquel-Rio,Judith Jericó-Escolar,Unai Sarriés-Serrano et al.
Lluis Miquel-Rio et al.
Anxiety and depression are common in Parkinson's disease (PD), affecting quality of life. Aggregates of α-synuclein (α-Syn) are found in serotonergic (5-HT) raphe nuclei early in the disease, but their relationship to brain changes is unc...
Glutamatergic synaptic resilience to overexpressed human alpha-synuclein [0.03%]
人α-突触核蛋白过表达条件下谷氨酸能突触的适应性反应
Patrícia I Santos,Inés Hojas García-Plaza,Ali Shaib et al.
Patrícia I Santos et al.
Alpha synuclein (aSyn) is abundant in the brain and strongly implicated in Parkinson's disease (PD), genetically and through its accumulation in neuronal pathognomonic inclusions. While mutations or increased expression of wild-type aSyn ca...
Remote real time digital monitoring fills a critical gap in the management of Parkinson's disease [0.03%]
远程实时数字监测在帕金森病管理中的重要作用
Aarushi S Negi,Shreesh Karjagi,Laura Parisi et al.
Aarushi S Negi et al.
People with Parkinson's disease (PWP) face significant gaps in care. Limited neurologist access, infrequent clinic visits, and inadequate symptom measurement culminate in suboptimal therapy and high morbidity. Quantitative Digitography (QDG...
Strain-specific effects of Desulfovibrio on neurodegeneration and oxidative stress in a Caenorhabditis elegans PD model [0.03%]
Desulfovibrio 菌株特异性诱发帕金森病线虫模型中神经退行性和氧化应激的效应
Khosrow Mohammadi,Dongming Zhang,Per Erik Joakim Saris
Khosrow Mohammadi
The gut microbiota is increasingly recognized as a key contributor to intestinal and brain pathologies, including Parkinson's disease (PD). Sulfate-reducing Desulfovibrio (DSV) species have emerged as microbial drivers through hydrogen sulf...
Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson's disease [0.03%]
尿素循环失调驱动帕金森病代谢应激和神经退行性病变
Shengyao Zhang,Guoran Wan,Yu Qiu et al.
Shengyao Zhang et al.
Parkinson's disease (PD), common neurodegenerative disorder, involves substantia nigra dopaminergic neuron loss and α-synuclein accumulation in Lewy bodies. While pathogenesis remains unclear, dysregulated urea metabolism may play a centra...
Parkinson's disease quality of life at 12 months comparing invasive device-aided therapy with oral treatment [0.03%]
与口服药物治疗相比，器械辅助治疗帕金森病一年后的生存质量状况研究
Adolfo Ramirez-Zamora,Michael S Okun,Pavnit Kukreja et al.
Adolfo Ramirez-Zamora et al.
Real-world impact of device-aided therapy on quality of life (QoL) in people with Parkinson's remains unknown. This large, retrospective, observational study assessed QoL in people transitioning to device-aided therapy (deep brain stimulati...