A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies [0.03%]
一种治疗路易 bodies病的脑内转运抗体
Sungwon An,John J McInnis,Dongin Kim et al.
Sungwon An et al.
Parkinson's disease and multiple system atrophy are members of a class of devastating neurodegenerative diseases called synucleinopathies, which are characterized by the presence of alpha-synuclein (α-Syn) rich aggregates in the brains of ...
Unraveling morphological brain network disparities Parkinsonian tremor from essential tremor: an artificial intelligence approach for clinical differentiation [0.03%]
基于人工智能的临床鉴别技术在帕金森病性震颤和特发性震颤间大脑形态学网络差异解析研究
Moxuan Zhang,Siyu Zhou,Huizhi Wang et al.
Moxuan Zhang et al.
Tremor-dominant Parkinson's disease (TD) and Essential Tremor (ET) are the two most common types of tremors, posing huge challenges in diagnosis. This study was to investigate the pathogenesis of tremors using brain morphology and employ ar...
Association between anxiety disorder, anxiolytic drugs, and risk of incident Parkinson's disease [0.03%]
焦虑症、抗焦虑药与帕金森病发病风险之间的关联性研究
Xiaoyan Hao,Zhiyun Wang,Yanmei Feng et al.
Xiaoyan Hao et al.
In this prospective cohort study, we analysed data from 502,364 participants (ages 40-69) in the UK Biobank, with follow-up until 2024. Logistic and Cox regression analysis identified generalized anxiety disorder (GAD) and obsessive-compuls...
Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum [0.03%]
路易体连续谱中皮层胆碱能通路与脑血管疾病的区域相关性研究
Anna Rennie,Milan Nemy,Cene Jerele et al.
Anna Rennie et al.
Cerebrovascular disease is common in patients on the Lewy body (LB) continuum (dementia with Lewy bodies (DLB) and prodromal-DLB). White matter signal abnormality (WMSA) volume is higher in patients with LB than controls, both globally and ...
Mehri Salari,Masoud Etemadifar,Alireza Vakilian et al.
Mehri Salari et al.
Millions of people worldwide suffer from Parkinson's disease (PD), which has a varying distribution and features in each country. Since there is a shortage of data regarding PD patients in Iran, we present a registry-based study to deepen o...
Revamping Parkinson's disease therapy using PLGA-based drug delivery systems [0.03%]
基于PLGA的药物输送系统在帕金森病治疗中的应用
Jude Majed Lababidi,Hassan Mohamed El-Said Azzazy
Jude Majed Lababidi
Parkinson's Disease (PD) involves degeneration of dopamine-producing neurons, mitochondrial dysfunction, alpha-synuclein aggregation, neuroinflammation, and gut-brain axis disturbances. Despite the availability of pharmacological treatments...
Parkinson's disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial [0.03%]
基于可穿戴设备信息与其它方法调整帕金森病药物剂量的随机临床试验
Alejandro Rodríguez-Molinero,Carlos Pérez-López,Nuria Caballol et al.
Alejandro Rodríguez-Molinero et al.
Parkinson's disease (PD) is characterized by motor fluctuations, with alternating periods of good ("ON") and poor ("OFF") motor function. Monitoring these fluctuations is crucial for optimizing treatment, yet traditional methods rely on sub...
Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson's disease [0.03%]
帕金森病中轻微幻觉数量与结构良好视觉幻觉的关联性研究
Haiying Zhang,Yang Zhao,Yi Chen et al.
Haiying Zhang et al.
Minor hallucinations (MH), comprising three subtypes (presence hallucinations, passage hallucinations, and visual illusions), typically emerge during the early stages of Parkinson's disease (PD) and precede the onset of well-structured visu...
Spontaneous eye blink-based machine learning for tracking clinical fluctuations in Parkinson's disease [0.03%]
基于自发性眨眼的机器学习在追踪帕金森病临床波动方面的应用
Noriko Nishikawa,Shin Tejima,Daiki Kamiyama et al.
Noriko Nishikawa et al.
In this uncontrolled, open-label exploratory clinical study, the authors explore the potential of blink data as a digital biomarker for estimating clinical indices of Parkinson's disease (PD) using a machine learning approach. Blink data we...
Associations of digestive diseases exposure and lifestyle factors with Parkinson's disease [0.03%]
消化系统疾病和生活习惯与帕金森病的关联性研究
Kaitai Yang,Ruitian Zeng,Yiling Zheng et al.
Kaitai Yang et al.
Emerging evidence highlights the importance of gastrointestinal (GI) dysfunction in Parkinson's disease (PD). While inflammatory bowel disease (IBD) has been linked to PD, the association with other GI conditions remains unclear. This study...