Predicting cognition after subthalamic Deep Brain Stimulation in Parkinson's Disease [0.03%]
预测帕金森病下丘脑深部刺激后的认知状况
Dorothee Kübler-Weller,Heiner Stuke,Melanie Astalosch et al.
Dorothee Kübler-Weller et al.
Cognitive deficits have a high impact on quality of life in Parkinson's disease (PD). This study takes into account the multifaceted etiology of cognition to estimate the cognitive outcome after deep brain stimulation (DBS) surgery in PD. C...
Longitudinal non-negative matrix factorization identifies the altered trajectory of motor symptoms in Parkinson's disease [0.03%]
纵向非负矩阵分解识别帕金森病运动症状改变的轨迹
Xinmin Hou,Kai Zhou,Yuxuan Wu et al.
Xinmin Hou et al.
Parkinson's disease (PD) is the second most common neurodegenerative disease with progressive structural alterations throughout the brain, resulting in motor symptoms that seriously affect patients' daily life. The present study then aimed ...
Balancing practicality and complexity in neuroimaging models of Parkinson's disease progression [0.03%]
帕金森病进展的神经影像模型的实用性和复杂性平衡研究
Valtteri Kaasinen,Thilo van Eimeren
Valtteri Kaasinen
Reliable progression models are essential for clinical decision-making and trial design in Parkinson’s disease. We discuss linear, exponential, and sigmoidal patterns in PET and SPECT data, emphasizing the mismatch between biomarker and cl...
Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation [0.03%]
氨基末端截短的α-突触核蛋白在病理及路易小体形成中的不同作用
Anne-Laure Mahul-Mellier,Melek Firat Altay,Niran Maharjan et al.
Anne-Laure Mahul-Mellier et al.
Alpha-synuclein (aSyn) post-translational modifications (PTM), especially phosphorylation at serine 129 and C-terminal truncations, are highly enriched in Lewy bodies (LB), Lewy neurites, and other pathological aggregates in Parkinson's dis...
Novel in situ seeding immunodetection assay uncovers neuronal-driven alpha-synuclein seeding in Parkinson's disease [0.03%]
新的原位播种免疫检测法揭示帕金森病中的神经元驱动α-突触核蛋白病理播种种机制
Maria Otero-Jimenez,Marcelina J Wojewska,Simona Jogaudaite et al.
Maria Otero-Jimenez et al.
Aggregates of alpha-synuclein (α-syn) propagate through template-induced misfolding in people with Parkinson's disease (PD) and Multiple System Atrophy (MSA). Prion-like seeding is crucial in disease initiation and progression, representin...
Supplementary motor area microstructure defines the extent of gait impairment in Parkinson's disease [0.03%]
补充运动区的微结构定义了帕金森病患者步态障碍的程度
Paweł P Wróbel,Annika Peter,Maja Kirsten et al.
Paweł P Wróbel et al.
Gait disorders and freezing of gait are challenging symptoms in Parkinson's disease. Cortical gait centers as the supplementary motor area appear to be relevant in gait control. We hypothesize that diffusion-MRI microstructural markers in t...
Synthetic MRI study of brain volume and subcortical myelin in various Parkinson's disease motor subtypes [0.03%]
不同帕金森病运动亚型的合成MRI脑体积和皮质下髓鞘研究
Dongliang Cheng,Junyan Wen,Nan Ding et al.
Dongliang Cheng et al.
Alterations in brain volume and subcortical myelin content (MyC) between tremor-dominant (TD) and postural instability and gait difficulty (PIGD) subtypes of Parkinson's (PD) disease remain unclear. This study investigated whole-brain volum...
Brain-region-specific lipid dysregulation in L-DOPA-induced dyskinesia in a primate model of Parkinson's disease [0.03%]
巴金森病猴模型中左多巴诱发不随意运动的脑区特异性脂质失调
Ibrahim Kaya,Theodosia Vallianatou,Anna Nilsson et al.
Ibrahim Kaya et al.
L-DOPA-induced dyskinesia (LID) is a significant and treatment-limiting complication in Parkinson's disease (PD) therapy, yet its mechanisms remain poorly understood. We used high-resolution mass spectrometry imaging to map brain-region-spe...
Alterations of the skin microbiome in multiple system atrophy: a pilot study [0.03%]
多系统萎缩患者皮肤微生物组的改变：一项初步研究
Daji Chen,Lang Sun,Linlin Wan et al.
Daji Chen et al.
Multiple system atrophy (MSA) alters skin physiology, potentially impacting skin microbiota. This pilot study investigated whether skin microbiota differs in MSA and whether these differences relate to disease severity. Using 16S rRNA seque...
New perspectives on molecular mechanisms underlying exercise-induced benefits in Parkinson's disease [0.03%]
运动改善帕金森病分子机制的最新研究进展
Xingyue Chen,Guoxin Zhang,Miao Liu et al.
Xingyue Chen et al.
Exercise offers neuroprotective benefits in Parkinson's disease (PD) by enhancing neurotrophic factors (e.g., BDNF, GDNF), improving mitochondrial function, reducing inflammation, and promoting autophagy. Irisin, a muscle-derived cytokine, ...