Independent serum metabolomics approaches identify disrupted glutamic acid and serine metabolism in Parkinson's disease patients [0.03%]
独立的血清代谢组学方法识别帕金森病患者的谷氨酸和甘氨酸代谢紊乱
Jacopo Gervasoni,Carmen Marino,Alberto Imarisio et al.
Jacopo Gervasoni et al.
Whether distinct blood metabolomic profiles can distinguish Parkinson's disease (PD) patients from healthy controls (HC) is still a matter of debate. Here, we employed ¹H-NMR and UPLC/MS analyses on serum samples from a cohort of PD patien...
Predicting Parkinson's disease and its progression based on radiomics in T1-weight images and α‑synuclein in cerebrospinal fluid [0.03%]
基于T1权像影像组学和脑脊液α-突触核蛋白预测帕金森病及其进展
Xu Zhang,Hui Li,Xiaona Xia et al.
Xu Zhang et al.
This study aimed to develop a radiomics model that can predict Parkinson's disease (PD) and its progression of using T1-weighted images (T1WI), and to evaluate the prediction performance of a multimodal model incorporating clinical factors....
Genome-wide association study of REM sleep behavior disorder in Parkinson's disease [0.03%]
帕金森病患者REM睡眠行为障碍的全基因组关联研究
Yuri L Sosero,Karl Heilbron,Pierre Fontanillas et al.
Yuri L Sosero et al.
REM sleep behavior disorder (RBD), is a prodromal synucleinopathy affecting a subset of Parkinson's disease (PD) patients and associated with neuropsychiatric symptoms. This study compared the genetic profiles of 13,020 PD patients with pro...
Direct disassembly of α-syn preformed fibrils into α-syn monomers by an all-D-peptide [0.03%]
全D-肽直接拆解α-突触核蛋白原纤维为α-突触核蛋白单体
Marc Sevenich,Ian Gering,Bettina Kass et al.
Marc Sevenich et al.
A hallmark of Parkinson's disease (PD) is the progressive neurodegeneration associated with soluble oligomeric and fibrillar forms of misfolded α-synuclein (α-syn). In this study, all-D-enantiomeric peptide ligands are presented that bind...
Methodological validation of Miro1 retention as a candidate Parkinson's disease biomarker [0.03%]
Miro1保留的候选帕金森病生物标志物的方法验证
Layla Drwesh,Giuseppe Arena,Daniel J Merk et al.
Layla Drwesh et al.
Mitochondrial markers help stratify Parkinson's disease (PD) patients. We use high-throughput blotting to quantify Miro1, Mfn2, and VDAC levels in fibroblasts, blood cells, and iPSC-derived neurons. Miro1 is specifically retained in PD cell...
Author Correction: Patterns of cerebellar cortex hypermetabolism on motor and cognitive functions in PD [0.03%]
作者更正：纹状体外侧部代谢异常与PD运动和认知功能的关系模式
Wen-Hua Ren,Bin Chen,Jiu-Qin He et al.
Wen-Hua Ren et al.
Published Erratum
NPJ Parkinson's disease. 2025 Aug 31;11(1):269. DOI:10.1038/s41531-025-01131-8 2025
Elevated hexosylceramides in Parkinson's disease cause gene upregulations in neurons mimicking responses to pathogens [0.03%]
帕金森病中神经酰胺糖基化升高导致基因上调，类似于对病原体的反应
Luisa Franck,Lisa Hahnefeld,Lucie Valek et al.
Luisa Franck et al.
Parkinson's Disease (PD) is driven by pathological aggregates of alpha-synuclein (αSyn), whose formation is facilitated by impaired glycosphingolipid metabolism via acidic glucocerebrosidase (GCase). We investigated glucosylceramide (GlcCe...
Yan Li,Millie McDonald-Webb,David J McLernon et al.
Yan Li et al.
Predicting outcomes for people with Parkinson's (PwP) can enable better information provision, personalised treatments, and enhanced trial design. It is unclear what prognostic models are optimal for use. We systematically reviewed previous...
Chronic adaptive deep brain stimulation for Parkinson's disease: clinical outcomes and programming strategies [0.03%]
用于帕金森病的慢性自适应深部脑刺激：临床结果和编程策略
Johannes L Busch,Jonathan Kaplan,Jennifer K Behnke et al.
Johannes L Busch et al.
Adaptive deep brain stimulation (DBS) dynamically adjusts stimulation amplitude based on neurophysiological feedback and may alleviate residual motor fluctuations in patients with Parkinson's disease. However, potential clinical benefits an...
Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis [0.03%]
Lrrk2 G2019S突变通过增加中性粒细胞固有的效应功能在感染性结肠炎模型中小肠发炎
Jessica Pei,Nathalia L Oliveira,Sherilyn J Recinto et al.
Jessica Pei et al.
Parkinson's Disease (PD) is a neurodegenerative disorder often preceded by gastrointestinal dysfunction. Mutations in leucine-rich repeat kinase 2 (LRRK2) are known risk factors for both PD and inflammatory bowel disease (IBD), suggesting a...