Resting and action tremor in Parkinson's disease: pathophysiological insights from long-term STN-DBS [0.03%]
长期STN-DBS对帕金森病静息震颤和行动性震颤的病理生理影响
Alessandro Zampogna,Antonio Suppa,Martina Patera et al.
Alessandro Zampogna et al.
Tremor is a well-recognized sign of Parkinson's disease (PD), yet its long-term evolution remains unclear, particularly regarding the relationship between resting and action tremor. This retrospective study examined resting and action tremo...
Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older [0.03%]
一份简短的气味辨别测试在六万多名60岁以上老年人中的百分比成绩报告
Kerri A Pierz,Whitley Aamodt,Caroline Gochanour et al.
Kerri A Pierz et al.
The study goal was to use a very large study cohort to establish normative data for the revised UPSIT (UPSIT-R) and to compare the resultant percentiles to those of the original UPSIT. A second study was performed to compare the performance...
Assessing prevalence and risk factors for REM sleep behavior disorder among patients with inflammatory bowel disease [0.03%]
评估炎症性肠病患者快速眼动睡眠行为障碍的患病率和危险因素
Vijaya L Reddy,Zihan Chen,Sohail Dewain et al.
Vijaya L Reddy et al.
REM sleep behavior disorder (RBD) and inflammatory bowel disease (IBD) are associated with Parkinson's Disease. Using a cross-sectional design, we assessed RBD prevalence in IBD and controls. In total, 158 controls and 462 IBD patients comp...
Severe GBA1 variants drive the GBA1-PD clinical phenotype: implications for counselling and clinical trials [0.03%]
GBA1严重突变体驱动GBA1-PD临床表型：对咨询和临床试验的意义
Elisa Menozzi,Sara Lucas Del Pozo,Jane Macnaughtan et al.
Elisa Menozzi et al.
Variants in the GBA1 gene are the commonest genetic risk factor for Parkinson disease (PD). Genotype-phenotype correlations exist but with conflicting data. Here, we compared the clinical phenotype of 183 idiopathic PD (iPD) patients, 39 se...
Altered habenular and whole brain functional connectivity in early Parkinson's disease using 7 T MRI [0.03%]
利用7T磁共振成像观察早期帕金森病纹状体和全脑功能连接的改变
Bedia Samanci,Ulas Ay,Mark L Kuijf et al.
Bedia Samanci et al.
Parkinson's disease (PD) is traditionally linked to basal ganglia dysfunction, yet evidence highlights broader network disruptions. Habenula, involved in regulating mood, reward, and motor functions, remains underexplored in PD. This study ...
Cerebral perfusion imaging predicts levodopa-induced dyskinesia in Parkinsonian rat model [0.03%]
脑灌注显像预测帕金森病大鼠模型左旋多巴诱导的异动症
Jarrad Perron,Sophia Krak,Samuel Booth et al.
Jarrad Perron et al.
Many Parkinson's disease (PD) patients manifest complications related to treatment called levodopa-induced dyskinesia (LID). Preventing the onset of LID is crucial to the management of PD, but the reasons why some patients develop LID are u...
Thalamic nuclei volume changes associated with cognitive and motor manifestations of Parkinson's disease [0.03%]
与帕金森病认知和运动表现相关的丘脑核体积变化
Vicente J Ferrer-Gallardo,Teresa Esteban-Peñalba,Maria C Rodriguez-Oroz et al.
Vicente J Ferrer-Gallardo et al.
Motor and cognitive symptoms are key features of Parkinson's disease (PD), which typically appear over time as the disease progresses. The thalamus, a central hub within basal ganglia-thalamocortical circuits, plays a crucial role in motor,...
Proteolytic activities of extracellular vesicles attenuate A-synuclein aggregation [0.03%]
外泌体的蛋白酶活性可减轻α-突触核蛋白聚集作用
Kostas Vekrellis,Agaristi Lamprokostopoulou,Katerina Melachroinou et al.
Kostas Vekrellis et al.
Extracellular vesicles (EVs) are nano-sized lipid vesicles released into the extracellular space. We investigated the role of mouse brain-derived EVs in α-synuclein (α-syn) degradation and pathology transmission. Using sucrose gradient is...
N-type Ca2+ channels mediate the stimuli-dependent α-synuclein secretion in mouse striatum [0.03%]
小鼠纹状体中刺激依赖性的α-突触核蛋白分泌由N型Ca2+通道介导
Emmanouela Leandrou,Ioanna Chalatsa,Kostas Vekrellis et al.
Emmanouela Leandrou et al.
The secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to...
Sleep stage mixing is associated with poor prognosis in early Parkinson's disease [0.03%]
睡眠分期混乱与早期帕金森病不良预后有关
Pauline Dodet,Emmanuel During,Isabelle Arnulf et al.
Pauline Dodet et al.
This study assessed the prognostic value of probabilistic sleep staging in early PD by quantifying sleep stage uncertainty and mixing. Data from two longitudinal cohorts (DeNoPa and ICEBERG) included 280 patients with early PD (mean duratio...