Shijie Wang,Kaela Kelly,Jonathan M Brotchie et al.
Shijie Wang et al.
Hyper-activated LRRK2 is linked to Parkinson's disease susceptibility and progression. Quantitative measures of LRRK2 inhibition, especially in the brain, maybe critical in the development of successful LRRK2-targeting therapeutics. In this...
Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations [0.03%]
携带PRKN突变的人脑和中脑类器官的小胶质细胞活化减弱
Masayoshi Kano,Masashi Takanashi,Genko Oyama et al.
Masayoshi Kano et al.
Parkin (encoded by PRKN) is a ubiquitin ligase that plays an important role in cellular mitochondrial quality control. Mutations in PRKN cause selective dopaminergic cell loss in the substantia nigra and are presumed to induce a decrease in...
Holly Woodrow,Malcolm K Horne,Chathurini V Fernando et al.
Holly Woodrow et al.
Medical conditions with effective therapies are usually managed with objective measurement and therapeutic targets. Parkinson's disease has effective therapies, but continuous objective measurement has only recently become available. This b...
Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease [0.03%]
多巴胺稳态的获得性失调重现帕金森病的特征
Meghan L Bucher,Caitlyn W Barrett,Connor J Moon et al.
Meghan L Bucher et al.
The catecholamine neurotransmitter dopamine has the potential to act as an endogenous neurotoxin when its vesicular sequestration is dysregulated. Despite postmortem analyses from patients with Parkinson's disease that demonstrate decreased...
Benedetta Demartini,Roberto William Invernizzi,Laura Campiglio et al.
Benedetta Demartini et al.
The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of ...
Effects of the agility boot camp with cognitive challenge (ABC-C) exercise program for Parkinson's disease [0.03%]
认知挑战下的敏捷训练营（ABC-C）对帕金森病患者的影响研究
Se Hee Jung,Naoya Hasegawa,Martina Mancini et al.
Se Hee Jung et al.
Few exercise interventions practice both gait and balance tasks with cognitive tasks to improve functional mobility in people with PD. We aimed to investigate whether the Agility Boot Camp with Cognitive Challenge (ABC-C), that simultaneous...
Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20 [0.03%]
过表达线粒体摄取受体TOM20对抗α-突触核蛋白诱导的多巴胺能神经元退行性变的作用
Briana R De Miranda,Emily M Rocha,Sandra L Castro et al.
Briana R De Miranda et al.
Dopaminergic neurons of the substantia nigra are selectively vulnerable to mitochondrial dysfunction, which is hypothesized to be an early and fundamental pathogenic mechanism in Parkinson's disease (PD). Mitochondrial function depends on t...
The CloudUPDRS smartphone software in Parkinson's study: cross-validation against blinded human raters [0.03%]
帕金森病研究中的CloudUPDRS智能手机软件与盲法人工评价者结果的一致性分析
Ashwani Jha,Elisa Menozzi,Rebecca Oyekan et al.
Ashwani Jha et al.
Digital assessments of motor severity could improve the sensitivity of clinical trials and personalise treatment in Parkinson's disease (PD) but have yet to be widely adopted. Their ability to capture individual change across the heterogene...
Dysfunction in superior frontal gyrus associated with diphasic dyskinesia in Parkinson's disease [0.03%]
与帕金森病双相异动症相关的额叶功能异常
Yu-Ting Shen,Yong-Sheng Yuan,Min Wang et al.
Yu-Ting Shen et al.
Alterations in brain function in Parkinson's disease (PD) patients with diphasic dyskinesia have not been investigated. We aimed to explore the alterations in regional brain function. Each of 53 levodopa (LD)-treated PD patients had two res...
Subthalamic deep brain stimulation improves sleep and excessive sweating in Parkinson's disease [0.03%]
丘脑底核深部脑刺激改善帕金森病患者的睡眠和过度出汗
Silje Bjerknes,Inger Marie Skogseid,Tuva Jin Hauge et al.
Silje Bjerknes et al.
Parkinson's disease (PD) is a complex multisystem disorder with motor and non-motor symptoms (NMS). NMS may have an even greater impact on quality of life than motor symptoms. Subthalamic nucleus deep brain stimulation (STN-DBS) has been sh...