Theta-frequency subthalamic stimulation enhances conflict resolution in Parkinson's disease patients with freezing of gait through frontal cortex modulation [0.03%]
θ频段底丘脑核刺激通过调节前额叶皮层缓解帕金森病患者的中轴症状冻结步态
Hutao Xie,Yutong Bai,Yutong Zhuang et al.
Hutao Xie et al.
Freezing of gait (FOG) in Parkinson's disease (PD) is a debilitating motor symptom linked to executive dysfunction, particularly impaired conflict resolution. However, the underlying neural mechanisms and optimal treatment remain unclear. W...
Long-term consistency of aperiodic and periodic physiomarkers in subthalamic local field potentials in Parkinson's disease [0.03%]
帕金森病丘脑底核电位中非周期性和周期性生理标志物的长期一致性
Mariëlle J Stam,Bernadette C M van Wijk,Arthur W G Buijink et al.
Mariëlle J Stam et al.
Beta oscillations (±13-35 Hz) and aperiodic spectral features extracted from local field potential (LFP) recordings have been identified as promising physiomarkers for adaptive deep brain stimulation (aDBS) in Parkinson's disease. However,...
Faecal microbiota transplant in Parkinson's disease: pilot study to establish safety & tolerability [0.03%]
帕金森病粪菌移植研究：建立安全性和耐受性的试点研究
Michele De Sciscio,Robert V Bryant,Sarah Haylock-Jacobs et al.
Michele De Sciscio et al.
Emerging evidence suggests gut microbiota differences in Parkinson's Disease (PD) may impact disease progression and treatment. Faecal Microbiota Transplantation (FMT) offers a potential therapeutic approach. We conducted an open-label pilo...
Multiparametric quantitative MRI uncovers putamen microstructural changes in Parkinson's disease [0.03%]
多参数定量磁共振成像揭示帕金森病患者苍白球微结构变化
Elior Drori,Lee Cohen,David Arkadir et al.
Elior Drori et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder dominated by motor and non-motor dysfunction. Despite extensive research, in vivo characterization of PD-related brain microstructure remains a challenge, limiting diagnos...
Novel technologies for REM sleep behavior disorder detection for home screening in Parkinson's disease and related alpha-synucleinopathies [0.03%]
针对帕金森病和α-突触核蛋白病的家庭筛查REM睡眠行为障碍检测的新技术
Kaat Colman,An-Marie Schyvens,Ilse De Volder et al.
Kaat Colman et al.
Isolated REM sleep behavior disorder (iRBD) is a prodromal marker of Parkinson's disease (PD) and related alpha-synucleinopathies. Identification of RBD is crucial for timely intervention and disease-modifying treatments. While video-polyso...
Gardenia-derived extracellular vesicles exert therapeutic effects on dopaminergic neuron apoptosis-mediated Parkinson's disease [0.03%]
使君子外泌体对多巴胺能神经元凋亡介导的帕金森病的治疗作用研究
Wen Chen,Haobo Wang,Xiang Ye et al.
Wen Chen et al.
Plant-derived extracellular vesicles (EVs) show health benefits. Gardenia jasminoides Ellis, known for its neuroprotective properties, lacks therapeutic investigation on gardenia-derived extracellular vesicles (GDEVs). This study investigat...
Beta-adrenoceptor drugs and progression to Parkinson's disease milestones in a large pooled incident cohort [0.03%]
β肾上腺素受体药物与大规模队列中帕金森病进展至临床里程碑的关系
Ruwani S Wijeyekoon,Marta Camacho,David Bäckström et al.
Ruwani S Wijeyekoon et al.
Beta-adrenoceptor-blockers and agonists have been associated with an increased and decreased risk of Parkinson's disease (PD), respectively. We aimed to investigate whether these medications are linked to clinical heterogeneity and progress...
Insights into ancestral diversity in Parkinson's disease risk: a comparative assessment of polygenic risk scores [0.03%]
帕金森病风险的祖先多样性洞察：多基因风险评分的比较评估
Paula Saffie-Awad,Spencer M Grant,Mary B Makarious et al.
Paula Saffie-Awad et al.
Risk prediction models play a crucial role in advancing healthcare by enabling early detection and supporting personalized medicine. Nonetheless, polygenic risk scores (PRS) for Parkinson's disease (PD) have not been extensively studied acr...
Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder [0.03%]
孤立的快速动眼睡眠行为障碍的大脑皮层宏观和微观结构变化
Jèssica Pardo,Ignacio Roura,Victor Montal et al.
Jèssica Pardo et al.
Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship ...
Machine learning for Parkinson's disease: a comprehensive review of datasets, algorithms, and challenges [0.03%]
帕金森病的机器学习综述：数据集、算法和挑战全面回顾
Sahar Shokrpour,AmirMehdi MoghadamFarid,Sepideh Bazzaz Abkenar et al.
Sahar Shokrpour et al.
Parkinson's disease (PD) is a devastating neurological ailment affecting both mobility and cognitive function, posing considerable problems to the health of the elderly across the world. The absence of a conclusive treatment underscores the...