Decreased SNCA expression in whole-blood RNA analysis of Parkinson's disease adjusting for neutrophils [0.03%]
校正中性粒细胞后全血RNA分析帕金森病SNCA表达降低
Kayla Y Xu,Ivo Violich,Elizabeth Hutchins et al.
Kayla Y Xu et al.
Blood-based RNA transcriptomics offers a promising avenue for identifying biomarkers of Parkinson's disease (PD) progression and mechanisms of pathogenesis. Previous work uncovered an age-related increase of neutrophil-enriched gene express...
Rita Bernhardt,Julia Schulze-Hentrich
Rita Bernhardt
Parkinson's disease (PD) has been proposed to be a predominantly genetic versus a mainly environmental disease. We suggest to consider PD rather as a disease caused by multi-dimensional factors, including genetic and environmental, but also...
Sneha Mantri,M Felice Ghilardi,Nicole Lessard et al.
Sneha Mantri et al.
This meeting report summarizes the proceedings of the inaugural World Summit on Parkinson’s Disease, held 11-13 June 2025 in Fiesole, Italy. The Summit was co-sponsored by the Parkinson’s Foundation and the Fresco Parkinson’s Institute. ...
Exposure to ambient air pollution and onset of Parkinson's disease in a large cohort study [0.03%]
基于大规模人群队列的环境空气污染暴露与帕金森病发病关联研究
Babak Jahanshahi,Duncan McVicar,Neil Rowland
Babak Jahanshahi
This population-based longitudinal cohort study examines the association between ambient air pollution (PM2.5 and NO2) and Parkinson's disease (PD) using a 28% representative sample of Northern Ireland's population (2009-2016). We matched c...
Targeting metabotropic glutamate receptors for symptomatic and disease-modifying treatment in Parkinson's disease [0.03%]
靶向代谢型谷氨酸受体以改善帕金森病的症状和改变疾病进程
Marika Alborghetti,Alessia Ceccherelli,Matteo Caridi et al.
Marika Alborghetti et al.
Degeneration of substantia nigra pars compacta dopaminergic neurons is the "hallmark" of Parkinson's disease (PD) and is responsible for motor signs. Other neurotransmitter systems are responsible for non-motor symptoms that may precede by ...
Investigating the ageing-Parkinson's disease nexus: standardisation of in vitro models and techniques by the PD-AGE network [0.03%]
PD-AGE网络探讨老龄化与帕金森病的关系：体外模型和技术标准化研究
Alexander G Bury,Alicja Olejnik,Chiara Tocco et al.
Alexander G Bury et al.
Ageing is the primary risk factor for Parkinson's disease, yet the intricate interplay between these processes remains ambiguous. This position paper, a collaborative output from the PD-AGE consortium, addresses the urgent need for standard...
The effects of aquaporin-4 polymorphisms on glymphatic function and motor symptoms in Parkinson's disease [0.03%]
多巴氏病患者中水通道蛋白-4基因多态性对其胶淋巴功能及运动症状的影响
Jianmei Qin,Yi Fang,Xiaojie Duanmu et al.
Jianmei Qin et al.
Growing evidence suggests that the glymphatic system, driven by aquaporin-4 (AQP4) water channels, plays a key role in Parkinson's disease (PD). We examined the impact of specific AQP4 variants on glymphatic function using diffusion tensor ...
Subjective cognitive decline in individuals with isolated REM sleep behavior disorder [0.03%]
局限于快动眼睡眠行为异常的个体中的主观认知下降现象
Anja Ophey,Sinah Röttgen,Christopher E J Doppler et al.
Anja Ophey et al.
Subjective cognitive decline (SCD) may constitute an early marker of mild cognitive impairment (MCI) in individuals with isolated REM sleep behavior disorder (iRBD). In this cross-sectional study, 80 individuals with iRBD were classified in...
Evaluating Parkinson's disease biomarkers in substantia nigra following sublethal γ-radiation exposure in a large animal model [0.03%]
评估亚致死剂量γ射线辐射大型动物模型黑质中的帕金森病生物标志物
Erin K Murphy,Daniel P Perl,Regina M Day et al.
Erin K Murphy et al.
Idiopathic Parkinson's Disease (iPD) involves genetic and environmental factors, including ionizing radiation. While high-dose radiation induces neurodegeneration, the effects of low-dose radiation (LDR) remain unclear. This study examined ...
Capsaicin and nicotine alleviate MPTP induced olfactory dysfunction by suppressing cGAS/TBK1/STING and MAPK mediated neuroinflammation [0.03%]
辣椒素和尼古丁通过抑制cGAS/TBK1/STING和MAPK介导的神经炎症缓解MPTP诱导的嗅觉障碍
Jingjing Wei,Linhai Wang,Dingzhong Wang et al.
Jingjing Wei et al.
Olfactory dysfunction serves as a potential early diagnostic biomarker for Parkinson's disease (PD), providing essential evidence for investigating PD pathogenesis and developing neuroprotective strategies. Capsaicin (CAP) and nicotine (Nic...