Cortical Pyramidal and Parvalbumin Cells Exhibit Distinct Spatiotemporal Extracellular Electric Potentials [0.03%]
皮层锥体细胞和副蛋白细胞表现出不同的时空细胞外电位
Lior J Sukman,Eran Stark
Lior J Sukman
Brain circuits are composed of diverse cell types with distinct morphologies, connections, and distributions of ion channels. Modeling suggests that the spatial distribution of the extracellular voltage during a spike depends on cellular mo...
Dragoş Cȋrneci,Mihaela Onu,Claudiu C Papasteri et al.
Dragoş Cȋrneci et al.
Training of autobiographical memory has been proposed as an intervention to improve cognitive function. The neural substrates for such improvements are poorly understood. Several brain areas have been previously linked to autobiographical r...
Maurice-Philipp Zech,Sandra Schäble,Tobias Kalenscher
Maurice-Philipp Zech
Temporal reward discounting describes the decrease of value of a reward as a function of delay. Decision-making between future aversive outcomes is much less studied, and there is no clear decision pattern across studies; while some authors...
Fast Synaptically Activated Calcium and Sodium Kinetics in Hippocampal Pyramidal Neuron Dendritic Spines [0.03%]
海马区锥体神经元树突棘中快速的突触激活钙钠动力学研究
Kenichi Miyazaki,William N Ross
Kenichi Miyazaki
An accurate assessment of the time course, components, and magnitude of postsynaptic currents is important for a quantitative understanding of synaptic integration and signaling in dendritic spines. These parameters have been studied in som...
Decoding the Time Course of Spatial Information from Spiking and Local Field Potential Activities in the Superior Colliculus [0.03%]
从上丘的尖峰和局部场电位活动中解码空间信息的时间过程
Michelle R Heusser,Clara Bourrelly,Neeraj J Gandhi
Michelle R Heusser
Place code representation is ubiquitous in circuits that encode spatial parameters. For visually guided eye movements, neurons in many brain regions emit spikes when a stimulus is presented in their receptive fields and/or when a movement i...
P2X7 Receptor and Purinergic Signaling: Orchestrating Mitochondrial Dysfunction in Neurodegenerative Diseases [0.03%]
P2X7受体和嘌呤能信号传导：在神经退行性疾病中调节线粒体功能障碍
Alexsandra S Zelentsova,Alexei V Deykin,Vladislav O Soldatov et al.
Alexsandra S Zelentsova et al.
Mitochondrial dysfunction is one of the basic hallmarks of cellular pathology in neurodegenerative diseases. Since the metabolic activity of neurons is highly dependent on energy supply, nerve cells are especially vulnerable to impaired mit...
Structural and Functional MRI Data Differentially Predict Chronological Age and Behavioral Memory Performance [0.03%]
结构和功能MRI数据对预测实际年龄和行为记忆表现的不同影响
Joram Soch,Anni Richter,Jasmin M Kizilirmak et al.
Joram Soch et al.
Human cognitive abilities decline with increasing chronological age, with decreased explicit memory performance being most strongly affected. However, some older adults show "successful aging," that is, relatively preserved cognitive abilit...
A Prospective Study of the Impact of Severe Childhood Deprivation on Brain White Matter in Adult Adoptees: Widespread Localized Reductions in Volume But Unaffected Microstructural Organization [0.03%]
童年剥夺对成人收养者的脑白质影响的前瞻性研究：体积减少但微结构组织未受影响
Nuria K Mackes,Mitul A Mehta,Ahmad Beyh et al.
Nuria K Mackes et al.
Early childhood neglect can impact brain development across the lifespan. Using voxel-based approaches we recently reported that severe and time-limited institutional deprivation in early childhood was linked to substantial reductions in to...
De Novo Brain-Computer Interfacing Deforms Manifold of Populational Neural Activity Patterns in Human Cerebral Cortex [0.03%]
从头开始的脑机接口改变了人脑皮层群体神经活动模式的手法
Seitaro Iwama,Yichi Zhang,Junichi Ushiba
Seitaro Iwama
Human brains are capable of modulating innate activities to adapt to novel environments and tasks; for sensorimotor neural system this means acquisition of a rich repertoire of activity patterns that improve behavioral performance. To direc...
Angular Tuning Properties of Low Threshold Mechanoreceptors in Isolated Rat Whisker Hair Follicles [0.03%]
孤立大鼠 whisker 毛囊中低阈值机械感受器的角调性质
Akihiro Yamada,Hidemasa Furue,Jianguo G Gu
Akihiro Yamada
Angular tuning is preferential sensory response to a directional stimulus and is observed in the whisker tactile system. In whisker hair follicles, there are at least three types of low threshold mechanoreceptors (LTMRs): rapidly adapting (...