Pattern of Driver-Like Input onto Neurons of the Mouse Ventral Lateral Geniculate Nucleus [0.03%]
小鼠外侧膝状体神经元的驱动信号样的输入模式研究
Gubbi Govindaiah,Michael A Fox,William Guido
Gubbi Govindaiah
The ventral lateral geniculate nucleus (vLGN) is a retinorecipient region of thalamus that contributes to a number of complex visual behaviors. Retinal axons that target vLGN terminate exclusively in the external subdivision (vLGNe), which ...
Neonatal Deafening Selectively Degrades the Sensitivity to Interaural Time Differences of Electrical Stimuli in Low-Frequency Pathways in Rats [0.03%]
新生儿耳聋选择性地降解大鼠低频通路中对双耳时间差异电刺激敏感性的研究
Woongsang Sunwoo
Woongsang Sunwoo
We examined the effect of neonatal deafening on frequency-specific pathways for processing of interaural time differences (ITDs) in cochlear-implant stimuli. Animal studies have demonstrated differences in neural ITD sensitivity in the infe...
Neural Dynamics during Binocular Rivalry: Indications from Human Lateral Geniculate Nucleus [0.03%]
双眼竞争过程中的神经动力学：来自人类外侧膝状体的迹象
Irem Yildirim,Keith A Schneider
Irem Yildirim
When two sufficiently different stimuli are presented to each eye, perception alternates between them. This binocular rivalry is conceived as a competition for representation in the single stream of visual consciousness. The magnocellular (...
Viral Tracing Confirms Paranigral Ventral Tegmental Area Dopaminergic Inputs to the Interpeduncular Nucleus Where Dopamine Release Encodes Motivated Exploration [0.03%]
病毒示踪证实了黑质外侧背盖区多巴胺能神经元投射至间脑核，且其中的多巴胺释放编码动力探索行为
Susanna Molas,Rubing Zhao-Shea,Timothy G Freels et al.
Susanna Molas et al.
Midbrain dopaminergic (DAergic) neurons of the ventral tegmental area (VTA) are engaged by rewarding stimuli and encode reward prediction error to update goal-directed learning. However, recent data indicate that VTA DAergic neurons are fun...
Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer's Disease Brains and Mouse Neurodegeneration Models [0.03%]
阿尔茨海默病大脑和小鼠神经退行模型中微胶质细胞差异表达Wnt信号调节分子DKK2
Nozie D Aghaizu,Sarah Jolly,Satinder K Samra et al.
Nozie D Aghaizu et al.
Wnt signaling is crucial for synapse and cognitive function. Indeed, deficient Wnt signaling is causally related to increased expression of DKK1, an endogenous negative Wnt regulator, and synapse loss, both of which likely contribute to cog...
Why Some Mice Are Smarter than Others: The Impact of Bone Morphogenetic Protein Signaling on Cognition [0.03%]
为什么有些小鼠比其他小鼠更聪明：骨形态发生蛋白信号对认知的影响
Jacqueline A Bonds,Elif Tunc-Ozcan,Sara R Dunlop et al.
Jacqueline A Bonds et al.
Inbred mice (C57Bl/6) display wide variability in performance on hippocampal-dependent cognitive tasks. Examination of microdissected dentate gyrus (DG) after cognitive testing showed a highly significant negative correlation between levels...
Age-Related Changes in Risky Decision Making and Associated Neural Circuitry in a Rat Model [0.03%]
大鼠模型中危险决策和相关神经回路的年龄相关变化
Caitlin A Orsini,Wonn S Pyon,Richard J Dragone et al.
Caitlin A Orsini et al.
Altered decision making at advanced ages can have a significant impact on an individual's quality of life and the ability to maintain personal independence. Relative to young adults, older adults make less impulsive and less risky choices; ...
Water-Reaching Platform for Longitudinal Assessment of Cortical Activity and Fine Motor Coordination Defects in a Huntington Disease Mouse Model [0.03%]
用于评估亨廷顿舞蹈病小鼠模型皮质功能和精细运动协调缺陷的水中平台测试系统
Yundi Wang,Marja D Sepers,Dongsheng Xiao et al.
Yundi Wang et al.
Huntington disease (HD), caused by dominantly inherited expansions of a CAG repeat results in characteristic motor dysfunction. Although gross motor defects have been extensively characterized in multiple HD mouse models using tasks such as...
Matteo Carandini
Matteo Carandini
The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats [0.03%]
中央杏仁核的垂体腺苷酸环化酶激活多肽(PACAP)系统介导了大鼠慢性社交失败应激的负面影响
Mariel P Seiglie,Lauren Lepeak,Clara Velázquez-Sanchez et al.
Mariel P Seiglie et al.
Many psychiatric diseases stem from an inability to cope with stressful events, as chronic stressors can precipitate or exacerbate psychopathologies. The neurobiological mechanisms underlying the response to chronic stress and the resulting...