Nonspiking Interneurons in the Drosophila Antennal Lobe Exhibit Spatially Restricted Activity [0.03%]
果蝇 antennal lobe 中的非爆发型中间神经元表现出空间受限的活动模式
Jonathan E Schenk,Quentin Gaudry
Jonathan E Schenk
Inhibitory interneurons are important for neuronal circuit function. They regulate sensory inputs and enhance output discriminability (Olsen and Wilson, 2008; Root et al., 2008; Olsen et al., 2010). Often, the identities of interneurons can...
Photothrombotic Middle Cerebral Artery Occlusion in Mice: A Novel Model of Ischemic Stroke [0.03%]
小鼠光诱导血栓性中动脉闭塞：一种缺血性卒中的新型模型
Emilia Conti,Noemi Carlini,Benedetta Piccardi et al.
Emilia Conti et al.
Stroke is one of the main causes of death and disability worldwide. Over the past decades, several animal models of focal cerebral ischemia have been developed allowing to investigate pathophysiological mechanisms underlying stroke progress...
Philipp Kreyenmeier,Luca Kämmer,Jolande Fooken et al.
Philipp Kreyenmeier et al.
Objects in our visual environment often move unpredictably and can suddenly speed up or slow down. The ability to account for acceleration when interacting with moving objects can be critical for survival. Here, we investigate how human obs...
A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses [0.03%]
标准非视觉行为事件在皮质视觉区域均匀传播而不调节视觉反应
Mahdi Ramadan,Eric Kenji Lee,Saskia de Vries et al.
Mahdi Ramadan et al.
Multiple recent studies have shown that motor activity greatly impacts the activity of primary sensory areas like V1. Yet, the role of this motor related activity in sensory processing is still unclear. Here, we dissect how these behavior s...
Pi USB Cam: A Simple and Affordable DIY Solution That Enables High-Quality, High-Throughput Video Capture for Behavioral Neuroscience Research [0.03%]
树莓派USB相机：一种简单经济的DIY解决方案，可实现行为神经科学研究中的高质量高吞吐量视频捕获
Shikun Hou,Elizabeth J Glover
Shikun Hou
Video recording is essential for behavioral neuroscience research, but the majority of available systems suffer from poor cost-to-functionality ratio. Commercial options frequently come at high financial cost that prohibits scalability and ...
Measuring Nonapoptotic Caspase Activity with a Transgenic Reporter in Mice [0.03%]
使用转基因报告小鼠检测非凋亡caspase活性
P J Nicholls,Thomas F Pack,Nikhil M Urs et al.
P J Nicholls et al.
The protease caspase-3 is a key mediator of apoptotic programmed cell death. But weak or transient caspase activity can contribute to neuronal differentiation, axonal pathfinding, and synaptic long-term depression. Despite the importance of...
Intrasession and Intersession Reproducibility of Artificial Scotoma pRF Mapping Results at Ultra-High Fields [0.03%]
超高磁场下人工盲点pRF映射结果的会内和会间可重复性
David Linhardt,Maximilian Pawloff,Michael Woletz et al.
David Linhardt et al.
Functional magnetic resonance imaging (fMRI) combined with population receptive field (pRF) mapping allows for associating positions on the visual cortex to areas on the visual field. Apart from applications in healthy subjects, this method...
Using SuperClomeleon to Measure Changes in Intracellular Chloride during Development and after Early Life Stress [0.03%]
使用SuperClomeleon测量发育过程中和早期生命压力后的细胞内氯化物变化
Lotte J Herstel,Carlijn Peerboom,Sten Uijtewaal et al.
Lotte J Herstel et al.
Intraneuronal chloride concentrations ([Cl-]i) decrease during development resulting in a shift from depolarizing to hyperpolarizing GABA responses via chloride-permeable GABAA receptors. This GABA shift plays a pivotal role in postnatal br...
Function of Excitatory Periaqueductal Gray Synapses in the Ventral Tegmental Area following Inflammatory Injury [0.03%]
炎症损伤后中脑腹侧被盖区的兴奋性中央导水管灰质突触功能研究
Claire Elena Manning,Michael Fritz,Julie Ann Kauer
Claire Elena Manning
Manipulating the activity of ventral tegmental area (VTA) dopamine (DA) neurons can drive nocifensive reflexes, and their firing rates are reduced following noxious stimuli. However, the pain-relevant inputs to the VTA remain incompletely u...
The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease [0.03%]
神经毒素DSP-4紊乱了蓝斑-去甲肾上腺素系统并使前驱神经退行性疾病的分子和行为特征重新表现出来
Alexa F Iannitelli,Michael A Kelberman,Daniel J Lustberg et al.
Alexa F Iannitelli et al.
The noradrenergic locus coeruleus (LC) is among the earliest sites of tau and α-synuclein pathology in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively. The onset of these pathologies coincides with loss of noradrenergic...