Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity [0.03%]
利用新型Klhl14-Cre小鼠品系选择性靶向一组定义完整的皮层脊髓神经元，从而能够从发育至成熟阶段开展分子和解剖学研究
Jake Lustig,Alexander Lammers,Julia Kaiser et al.
Jake Lustig et al.
The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPN) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular deli...
Gut microbiota and white matter integrity: a two-sample Mendelian randomization analysis [0.03%]
肠道微生物群和白质完整性：两样本孟德尔随机化分析
Lan Zhang,Xiao-Wei Pang,Lu-Yang Zhang et al.
Lan Zhang et al.
The causal relationship between gut microbiota (GM) and white matter injury and communication remains unclear. We aimed to scrutinize the plausible causal impact of GM on white matter hyperintensities (WMH), white matter microstructure, whi...
Tequila, the serine protease is involved in sleep-dependent memory consolidation in Drosophila [0.03%]
.tequila丝氨酸蛋白酶参与果蝇睡眠依赖型记忆巩固
Aishwarya Segu,Shrutika Sansaria,Nisha N Kannan
Aishwarya Segu
Sleep is a vital physiological phenomenon observed amongst almost all organisms. Although its exact purpose remains elusive, sleep has been linked to memory consolidation. In our present study, we investigated the role of sleep quality on s...
Thiamine Mitigates Nicotine Withdrawal Effects in Adolescent Male Rats: Modulation of Serotonin Metabolism, BDNF, Oxidative Stress, and Neuroinflammation [0.03%]
维生素B1通过调节血清素代谢、BDNF、氧化应激和神经炎症缓解青春期雄性大鼠的尼古丁戒断效应
Murtaza Haidary,Elham Akbari,Mohammad Edris Amiri et al.
Murtaza Haidary et al.
Adolescent nicotine use is particularly concerning due to increased susceptibility to long-term effects and dependence during this critical developmental period. This study investigates the therapeutic effects of thiamine on nicotine withdr...
Neuronal Colocalization of μ-Opioid Receptor, κ-Opioid Receptor, and Oxytocin Receptor mRNA in the Central Nucleus of the Amygdala in Male and Female Mice [0.03%]
雄性和雌性小鼠中枢杏仁核μ-阿片受体、κ-阿片受体和催产素受体mRNA的共定位研究
Khalin E Nisbett,George F Koob
Khalin E Nisbett
Given the observed interaction and reports of oxytocin, μ-opioid receptor, or κ-opioid receptor expression in brain regions important to emotion regulation (i.e., the central amygdala), we hypothesized that oxytocin (oxtr), μ-opioid (opr...
Single cell approaches define the murine leptomeninges:cortical brain interface as a distinct cellular neighborhood comprised of neural and nonneural cell types [0.03%]
单细胞方法定义小鼠软脑膜:皮层脑界面为一个独特的由神经和非神经元类型组成的细胞区域
Sarah N Ebert,Christine Eisner,Konstantina Karamboulas et al.
Sarah N Ebert et al.
The interface barrier between the brain surface and the adjacent meninges is important for regulating exchanges of fluid, protein and immune cells between the CNS and periphery. However, the cell types that form this important interface are...
Oxytocin Receptor Expression and Activation in Parasympathetic Brainstem Cardiac Vagal Neurons [0.03%]
催产素受体在副交感脑干心脏迷走神经元中的表达和激活作用
Xin Wang,Caitlin Ribeiro,Anna Nilsson et al.
Xin Wang et al.
Autonomic imbalance - particularly reduced activity from brainstem parasympathetic cardiac vagal neurons (CVNs)-is a major characteristic of many cardiorespiratory diseases. Therapeutic approaches to selectively enhance CVN activity have be...
Bichromatic exon-reporters reveal voltage-gated Ca2+-channel spliceisoform diversity across Drosophila neurons in vivo [0.03%]
双色外显子报道在果蝇神经元中揭示了电压门控Ca2 +通道剪接异构体的多样性
Touhid Feghhi,Roberto X Hernandez,Olena Mahneva et al.
Touhid Feghhi et al.
Every neuron contains the same genomic information but its complement of proteins is the product of countless neuron-specific steps including pre-mRNA splicing. Despite advances in RNA sequencing techniques, pre-mRNA splicing biases that fa...
Bruno F Cruz,Paulo Carriço,Luís Teixeira et al.
Bruno F Cruz et al.
Experimental behavioral neuroscience relies on the ability to deliver precise amounts of liquid volumes to animal subjects. Among others, it allows the progressive shaping of behavior through successive, automated, reinforcement, thus allow...
Experience-Dependent Intrinsic Plasticity in Layer IV of Barrel Cortex at Whisking Onset [0.03%]
whisking开始时桶状皮层IV层中与经验有关的固有可塑性
Molly C Shallow,Lucy Tian,Bryan T Higashikubo et al.
Molly C Shallow et al.
The development of motor control over sensory organs is a critical milestone, enabling active exploration and shaping of the sensory environment. Whether the onset of sensory organ motor control directly influences the development of corres...