Aberrant Emotion-Cognition Integration in FMR1 Premutation Carriers: a fNIRS Study [0.03%]
FMR1前突变携带者的异常情绪-认知整合：一项fNIRS研究
Yuewen Bian,Yuhang Li,Yiting Zhu et al.
Yuewen Bian et al.
Carriers of the FMR1 (Fragile X Messenger Ribonucleoprotein 1) premutation (55-200 CGG repeats on the X chromosome), known as premutation carriers (PMCs), often exhibit executive dysfunction. Yet, the neural mechanism of cognitive and execu...
Pre-Training for Large-Scale Functional Connectome Fingerprinting Supports Generalization and Transfer Learning in Functional Neuroimaging [0.03%]
大规模功能连接组指纹的预训练支持功能神经影像中的泛化和迁移学习
Mattson Ogg,Lindsey Kitchell
Mattson Ogg
Functional MRI currently supports a limited application space stemming from modest dataset sizes, large interindividual variability and heterogeneity among scanning protocols. These constraints have made it difficult for fMRI researchers to...
Connectome-guided personalization of optimal tDCS intervention selection in Alzheimer's disease: A modeling study [0.03%]
基于连接组的个性化经颅直流电刺激干预选择在阿尔茨海默病中的应用：一种建模研究
Janne J Luppi,Annel P Koomen,Cornelis J Stam et al.
Janne J Luppi et al.
Transcranial direct current stimulation (tDCS) could reduce the neurophysiological effects in Alzheimer's disease (AD), but progress is hampered by variable outcomes across studies, likely related to both methodological and individual diffe...
Therapeutic Potential of Platelet-Derived Growth Factor-B-Modified Nanoparticles in Enhancing Pericyte Activation for Acute Ischemic Stroke [0.03%]
血小板源性生长因子B修饰的纳米颗粒在激活急性缺血性脑卒中微环境周细胞中的治疗潜能研究
Satoshi Karashima,Koichi Arimura,Ryusuke Hatae et al.
Satoshi Karashima et al.
Platelet-derived growth factor subunit B (PDGF-B) signaling plays a critical role in pericyte activation and neurovascular repair following ischemic injury. Although enhancing PDGF-B signaling in pericytes represents a promising therapeutic...
Hippocampal gene expression in zebra finches reveals sex- and subregion-specific topographies [0.03%]
环斑丛鸦莺海马区的基因表达在性别和亚区之间存在特定的空间分布格局
Alexander C Taylor,Chinweike N Asogwa,Changjiu Zhao et al.
Alexander C Taylor et al.
The hippocampus is a highly evolutionarily conserved brain region that supports spatial memory, stress responses, and social behavior across vertebrates. While mammalian hippocampal transcriptomics have been extensively characterized, compa...
Sustaining Drug Discovery Amid the Limits of Alzheimer's Disease Immunotherapies [0.03%]
阿尔茨海默病免疫疗法的局限性背景下维持药物发现工作
Amina McDiarmid
Amina McDiarmid
Accumulation of insoluble extracellular amyloid-β (Aβ) plaques and intraneuronal fibrillary hyperphosphorylated tau fibrils in the brain are widely believed to contribute to the progressive neurodegeneration and neuronal loss characterist...
GluN2A Enables Noradrenergic Control of Prefrontal Oscillations and Cognitive Flexibility [0.03%]
GluN2A使去甲肾上腺素控制前额叶振荡和认知灵活性
Hassan Hosseini,Sky Evans-Martin,Emma Bogomilsky et al.
Hassan Hosseini et al.
Cognitive flexibility-the ability to adapt behavior when contingencies change-is impaired in psychiatric disorders involving prefrontal dysfunction. The medial prefrontal cortex (mPFC) relies on noradrenergic input from the locus coeruleus ...
Yessenia Magaña,Shanshan Wang,Albertina Torreblanca-Zanca et al.
Yessenia Magaña et al.
Adeno-associated virus (AAV) vectors are widely used for neuroscience research. Labeling AAV mRNA by in situ hybridization can track AAV transduction with high sensitivity and without the need for reporter genes. However, it is challenging ...
Zebra finch introductory notes become song-like but have different timing and acoustic correlations with the song that follows [0.03%]
虎皮鹦鹉的入门笔记变得像歌曲一样，但与随后的歌曲有不同的时间和声学相关性
Divya Rao,Devika Babu Kizhakoot,Shikha Kalra et al.
Divya Rao et al.
Male zebra finches begin their song bouts by repeating a short sound called an introductory note (IN). As INs repeat, their timing and acoustic properties change, similar to pre-movement neural preparatory activity seen in primates and rode...
Hemifield-Specific Motion Extrapolation Reveals Limits of Interhemispheric Integration [0.03%]
半球特异性运动外插显示半球间整合的局限性
Coleman E Olenick,Mazyar Fallah
Coleman E Olenick
The accurate perception of moving objects is a fundamental challenge for the visual system, which must compensate for neural processing delays. Motion extrapolation is a proposed mechanism whereby the brain predicts an object's future posit...