miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration [0.03%]
microRNA-146a通过靶向免疫抑制中性粒细胞和增强CD8+T细胞浸润来抑制卵巢肿瘤的生长
Rui Chen,Elaina Coleborn,Chintan Bhavsar et al.
Rui Chen et al.
Immunotherapies have emerged as promising strategies for cancer treatment. However, existing immunotherapies have poor activity in high-grade serous ovarian cancer (HGSC) due to the immunosuppressive tumor microenvironment and the associate...
Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate [0.03%]
一种针对间皮素的新型人源抗体可变区作为抗体药物偶联物的临床前评估研究
Zehua Sun,Xiaojie Chu,Cynthia Adams et al.
Zehua Sun et al.
Mesothelin (MSLN) has been a validated tumor-associated antigen target for several solid tumors for over a decade, making it an attractive option for therapeutic interventions. Novel antibodies with high affinity and better therapeutic prop...
Oncolytic myxoma virus is effective in murine models of triple negative breast cancer despite poor rates of infection [0.03%]
溶细胞性黏液瘤病毒可有效治疗三阴乳腺癌小鼠模型尽管感染效率低
Raquela J Thomas,Mee Y Bartee,Miriam Valenzuela-Cardenas et al.
Raquela J Thomas et al.
Oncolytic viruses are being heavily investigated as novel methods to treat cancers; however, predicting their therapeutic efficacy remains challenging. The most commonly used predictive tests involve determining the in vitro susceptibility ...
Smoking induces WEE1 expression to promote docetaxel resistance in esophageal adenocarcinoma [0.03%]
吸烟通过上调WEE1诱导食管腺癌耐药机制研究
Md Obaidul Islam,Krishnapriya Thangaretnam,Heng Lu et al.
Md Obaidul Islam et al.
Esophageal adenocarcinoma (EAC) patients have poor clinical outcomes, with an overall 5-year survival rate of 20%. Smoking is a significant risk factor for EAC. The role of WEE1, a nuclear kinase that negatively regulates the cell cycle in ...
Transgenic viral expression of PH-20, IL-12, and sPD1-Fc enhances immune cell infiltration and anti-tumor efficacy of an oncolytic virus [0.03%]
转基因表达PH-20、IL-12和sPD1-Fc可增强溶瘤病毒对免疫细胞的募集及抗肿瘤效果
Soon-Oh Hong,Joonsung Kim,Sungmin Lee et al.
Soon-Oh Hong et al.
Oncolytic viruses are of significant clinical interest due to their ability to directly infect and kill tumors and enhance the anti-tumor immune response. Previously, we developed KLS-3010, a novel oncolytic virus derived from the Internati...
Claudin18.2 bispecific T cell engager armed oncolytic virus enhances antitumor effects against pancreatic cancer [0.03%]
针对 Claudin18.2的双特异性T细胞衔接病毒型溶瘤病毒增强对胰腺癌的抗肿瘤作用
Shiyu Liu,Fan Li,Li Deng et al.
Shiyu Liu et al.
Bispecific T cell engagers (BiTEs) represent a promising immunotherapy, but their efficacy against immunologically cold tumors such as pancreatic ductal adenocarcinoma remains unclear. Oncolytic viruses (OVs) can transform the immunosuppres...
A new strategy for treating colorectal cancer: Regulating the influence of intestinal flora and oncolytic virus on interferon [0.03%]
一种新的肠癌治疗策略：调控肠道菌群及溶瘤病毒对干扰素的影响
Jia Yi,Peizhe Lin,Qingbo Li et al.
Jia Yi et al.
Colorectal cancer (CRC) has the third highest incidence and the second highest mortality in the world, which seriously affects human health, while current treatments methods for CRC, including systemic therapy, preoperative radiotherapy, an...
Interleukin-6-controlled, mesenchymal stem cell-based sodium/iodide symporter gene therapy improves survival of glioblastoma-bearing mice [0.03%]
白细胞介素-6控制的间质干细胞基钠/碘辛porter基因治疗可改善胶质母细胞瘤小鼠的存活率
Carolin Kitzberger,Khuram Shehzad,Volker Morath et al.
Carolin Kitzberger et al.
New treatment strategies are urgently needed for glioblastoma (GBM)-a tumor resistant to standard-of-care treatment with a high risk of recurrence and extremely poor prognosis. Based on their intrinsic tumor tropism, adoptively applied mese...
The quest for effective immunotherapies against malignant peripheral nerve sheath tumors: Is there hope? [0.03%]
寻找恶性外周神经鞘肿瘤有效免疫治疗的探索：还有希望吗？
Siddhi N Paudel,Brian Hutzen,Timothy P Cripe
Siddhi N Paudel
Immune-based therapies represent a new paradigm in the treatment of multiple cancers, where they have helped achieve durable and safe clinical responses in a growing subset of patients. While a wealth of information is available concerning ...
JNTX-101, a novel albumin-encapsulated gemcitabine prodrug, is efficacious and operates via caveolin-1-mediated endocytosis [0.03%]
新型白蛋白包封吉西他滨前体药物JNTX-101的抗肿瘤作用及作用机制研究
Tiantian Cui,Sergio Corrales-Guerrero,Veronica Castro-Aceituno et al.
Tiantian Cui et al.
Albumin is an attractive candidate carrier for the development of novel therapeutic drugs. Gemcitabine has been FDA approved for the treatment of solid tumors; however, new drugs that optimize gemcitabine delivery are not available for clin...