Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML [0.03%]
通过治疗性细胞疫苗重新激活急性髓系白血病患者的先天性和适应性免疫反应
Shin-Ichiro Fujii,Toyotaka Kawamata,Kanako Shimizu et al.
Shin-Ichiro Fujii et al.
Strategies integrating activation of innate and adaptive immunity against cancer are desired. We established a novel platform, Wilms' tumor antigen 1 (WT1)-expressing artificial adjuvant vector cells (aAVC-WT1), linking invariant natural ki...
Timothy P Cripe
Timothy P Cripe
Minyue Shou,Hanyu Zhou,Ling Ma
Minyue Shou
Yanqi Ye,Nanhai G Chen
Yanqi Ye
The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges [0.03%]
囊泡在三阴性乳腺癌中的作用及应用：机遇与挑战
Ya-Nan Wei,Chun-Yan Yan,Meng-Lu Zhao et al.
Ya-Nan Wei et al.
Extracellular vesicles (EVs) carry DNA, RNA, protein, and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. Triple-negative breast cancer (TNBC) is rich in recurrent and metastatic dise...
Pre-treatment with systemic agents for advanced NSCLC elicits changes in the phenotype of autologous T cell therapy products [0.03%]
系统治疗后用于治疗晚期NSCLC的自体T细胞疗法产品的表型变化
Charlotte O&#x;Brien Gore,Amy Billman,Suchete Hunjan et al.
Charlotte O&#x;Brien Gore et al.
The antitumor activity of adoptive T cell therapies (ACT) is highly dependent on the expansion, persistence, and continued activity of adoptively transferred cells. Clinical studies using ACTs have revealed that products that possess and ma...
Kinetic analysis of oncolytic OrfV-induced innate and adaptive immune responses in a murine model of late-stage ovarian cancer [0.03%]
猫豆病毒溶瘤活性及其诱导机体免疫反应的机制研究
Jessica A Minott,Jacob P van Vloten,Jake G E Yates et al.
Jessica A Minott et al.
Immunotherapies revive host immune responses against tumors by stimulating innate and adaptive immune effector cells with antitumor functions. Thus, detailed studies of immunological cell phenotypes and functions within the tumor microenvir...
Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers [0.03%]
除了ENO1：癌症中其他烯醇酶的新角色和靶向策略
Jiaojiao Ni,Yihui Huang,Chaoqun Li et al.
Jiaojiao Ni et al.
Aerobic glycolysis is a hallmark property of cancer metabolism. Enolase is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In mammals, enolases exist in three isoforms, encoded by the genes ...
Cem Elbi
Cem Elbi
Treatment with the PPARα agonist fenofibrate improves the efficacy of CD8+ T cell therapy for melanoma [0.03%]
PPARα激动剂非诺贝特的治疗可提高CD8+T细胞对黑色素瘤疗效
Mohadeseh Hasanpourghadi,Arezki Chekaoui,Sophia Kurian et al.
Mohadeseh Hasanpourghadi et al.
Adoptive transfer of tumor antigen-specific CD8+ T cells can limit tumor progression but is hampered by the T cells' rapid functional impairment within the tumor microenvironment (TME). This is in part caused by metabolic stress due to lack...