Jacob L Léger,Lee-Hwa Tai
Jacob L Léger
Bispecific CD33/CD123 targeted chimeric antigen receptor T cells for the treatment of acute myeloid leukemia [0.03%]
双特异针对CD33/CD123嵌合抗原受体T细胞治疗急性髓系白血病
Justin C Boucher,Bishwas Shrestha,Paresh Vishwasrao et al.
Justin C Boucher et al.
CD33 and CD123 are expressed on the surface of human acute myeloid leukemia blasts and other noncancerous tissues such as hematopoietic stem cells. On-target off-tumor toxicities may limit chimeric antigen receptor T cell therapies that tar...
Bacterial cancer therapy using the attenuated fowl-adapted Salmonella enterica serovar Gallinarum [0.03%]
减毒禽适应性沙门氏菌鸡胚亚种细菌癌症治疗
Daejin Lim,Kwangsoo Kim,Taner Duysak et al.
Daejin Lim et al.
We report here a novel anti-cancer therapy based on an avian-host-specific serotype Salmonella enterica serovar Gallinarum (S. Gallinarum) deficient in ppGpp synthesis. To monitor the tumor targeting, a bioluminescent ΔppGpp S. Gallinarum ...
Dual blockade of CD47 and CD24 signaling using a novel bispecific antibody fusion protein enhances macrophage immunotherapy [0.03%]
一种新型双特异性抗体融合蛋白通过同时阻断CD47和CD24信号通路增强巨噬细胞免疫治疗
Yun Yang,He Wu,Yan Yang et al.
Yun Yang et al.
CD47 and its receptor signal regulatory protein α (SIRPα) act as a dominant antiphagocytic, "don't eat me" signal. Recent studies reveal CD24 as a novel target for cancer immunotherapy by macrophages in ovarian cancer and breast cancer. H...
Improved oncolytic activity of a reovirus mutant that displays enhanced virus spread due to reduced cell attachment [0.03%]
一种由于细胞附着减少而导致病毒扩散增强的溶瘤活性改善的重组雷噬菌体变异毒株
Francisca Cristi,Maiah Walters,Nashae Narayan et al.
Francisca Cristi et al.
Wild-type reovirus serotype 3 Dearing (T3wt), a non-pathogenic intestinal virus, has shown promise as a cancer therapy in clinical trials, but it would benefit from an increased potency. Given that T3wt is naturally adapted to the intestina...
Zhi Li,Jiuwei Cui
Zhi Li
Lactic acid is one of the most abundant products of cellular metabolism and has historically been considered a cell-damaging metabolic product. However, as research has deepened, the beneficial effects of lactic acid on tumor cells and the ...
Retraction Notice to: miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT/p70S6K and JNK Pathways through ABHD2 [0.03%]
撤销文章：miR-140-3p通过ABHD2破坏AKT/p70S6K和JNK途径抑制皮肤黑色素瘤进展
Yuanmin He,Yan Yang,Yongmei Liao et al.
Yuanmin He et al.
[This retracts the article DOI: 10.1016/j.omto.2020.03.009.]. © 2023 The Author(s).
Retraction of Publication
Molecular therapy oncolytics. 2023 Nov 3:31:100742. DOI:10.1016/j.omto.2023.100742 2023
An epitope encoded by uORF of RNF10 elicits a therapeutic anti-tumor immune response [0.03%]
由RNF10的uORF编码的表位引发治疗性抗肿瘤免疫反应
Lili Zeng,Wei Zheng,Jiahui Zhang et al.
Lili Zeng et al.
Tumor-specific antigens (TSAs) are crucial for tumor-specific immune response that reduces tumor burden and thus serve as important targets for immunotherapy. Identification of novel TSAs can provide new strategies for immunotherapies. In t...
Replication-incompetent influenza A viruses armed with IFN-γ effectively mediate immune modulation and tumor destruction in mice harboring lung cancer [0.03%]
一种复制缺陷的流感病毒能够携带干扰素-γ有效调节小鼠肺癌免疫并破坏肿瘤细胞
Ramona Meissner,Viktor Wixler,Franziska Paulina Wulfert et al.
Ramona Meissner et al.
Low pathogenic influenza A viruses (IAVs) have shown promising oncolytic potential in lung cancer-bearing mice. However, as replication-competent pathogens, they may cause side effects in immunocompromised cancer patients. To circumvent thi...
Erratum: CM082 Enhances the Efficacy of Chemotherapeutic Drugs by Inhibiting the Drug Efflux Function of ABCG2 [0.03%]
校正：CM082通过抑制ABCG2的药物外排功能增强化疗药疗效
Lejia Xu,Jiwei Huang,Jie Liu et al.
Lejia Xu et al.
[This corrects the article DOI: 10.1016/j.omto.2019.12.007.]. © 2023 The Author(s).
Published Erratum
Molecular therapy oncolytics. 2023 Nov 10:31:100746. DOI:10.1016/j.omto.2023.100746 2023