FLCN: A new regulator of AMPK-dependent Warburg metabolic reprogramming [0.03%]
FLCN：一种新的依赖于AMPK的瓦博格代谢重构调节因子
Marie-Claude Gingras,Arnim Pause
Marie-Claude Gingras
Tumor cells manage their energy to support aberrant proliferation by reprogramming their cellular metabolism, for example through the Warburg effect. Although AMPK is a major regulator of energy homeostasis, its role in cancer metabolic ada...
The Epithelial-to-Mesenchymal Transition (EMT), a Particular Case [0.03%]
上皮间质转化（epithelial-mesenchymal transition，EMT）的特殊情形
Joan Pau Cebrià-Costa,Alba Millanes-Romero,Antonio García de Herreros et al.
Joan Pau Cebrià-Costa et al.
Constitutive heterochromatin, an essential structure that has been conserved throughout evolution, is required to maintain genome stability. Although heterochromatin is enriched for repressive traits, it can be actively transcribed to gener...
Regulation of cancer stem-like cell differentiation by Smac mimetics [0.03%]
凋亡蛋白Smac模拟物通过调节肿瘤起始细胞分化抑制肿瘤生长和转移
Simone Fulda
Simone Fulda
Small-molecule antagonists of inhibitor of apoptosis (IAP) proteins such as Smac mimetics are considered promising cancer therapeutics through the engagement of cell death pathways. Recent evidence suggests that Smac mimetics perform additi...
Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140 [0.03%]
转录辅调节因子RIP140调节肠内稳态和肿瘤发生
Vincent Cavaillès,Marion Lapierre
Vincent Cavaillès
Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 a...
Zhenyu Cai,Zheng-Gang Liu
Zhenyu Cai
Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptor...
Sean G Rudd,Julie Bianchi,Aidan J Doherty
Sean G Rudd
The DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase superfamily represents an ancient solution to the many problems faced during genome duplication. This versatile enzyme is capable of initiating de novo DNA/RNA sy...
Approaches to uncovering cancer diagnostic and prognostic molecular signatures [0.03%]
揭示癌症诊断和预后分子特征的方法
Shengjun Hong,Yi Huang,Yaqiang Cao et al.
Shengjun Hong et al.
The recent rapid development of high-throughput technology enables the study of molecular signatures for cancer diagnosis and prognosis at multiple levels, from genomic and epigenomic to transcriptomic. These unbiased large-scale scans prov...
Homologous recombination maintenance of genome integrity during DNA damage tolerance [0.03%]
同源重组在DNA损伤耐受过程中的作用及其对基因组稳定性的维护
Félix Prado
Félix Prado
The DNA strand exchange protein Rad51 provides a safe mechanism for the repair of DNA breaks using the information of a homologous DNA template. Homologous recombination (HR) also plays a key role in the response to DNA damage that impairs ...
Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes [0.03%]
与内质网膜相关线粒体的致癌和抑癌信号转导
Saverio Marchi,Carlotta Giorgi,Monika Oparka et al.
Saverio Marchi et al.
The different mechanisms employed by proto-oncogenes and tumor suppressors to regulate cell death pathways are strictly linked to their localization. In addition to the canonical control of apoptosis at a transcriptional/nuclear level, intr...
Dong Wook Choi,Cheol Yong Choi
Dong Wook Choi
Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine protein kinase that participates in the regulation of diverse cellular activities as a transcriptional cofactor and signal transducer. HIPK2 senses various signaling cue...