Di Zhao,Fu-Long Li,Zhou-Li Cheng et al.
Di Zhao et al.
Acetylation of protein lysine residues is a reversible and dynamic process that is controlled by histone acetyltransferases (HATs) and deacetylases (HDACs and SIRTs). Recent studies have revealed that acetylation modulates not only nuclear ...
Theodora S Ross,Victoria E Mgbemena
Theodora S Ross
Chronic myelogenous leukemia (CML) requires the BCR/ABL tyrosine kinase for disease onset and maintenance. As a result, CML can be successfully treated with tyrosine kinase inhibitors (TKIs) such as imatinib. Most patients are maintained in...
Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment [0.03%]
基于理性的PI3K抑制剂联合治疗癌症的策略
Pau Castel,Eneda Toska,Zachary S Zumsteg et al.
Pau Castel et al.
The PI3K/AKT/mTOR signaling is important for cell proliferation, survival, and metabolism. Hyperactivation of this pathway is one of the most common signaling abnormalities observed in cancer and a substantial effort has recently been made ...
Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism [0.03%]
突变的p53通过调节癌细胞代谢发挥致癌功能
Ge Zhou,Jeffrey N Myers
Ge Zhou
The metabolic function of p53 is important for its oncosuppressive function. Mutant p53 (mutp53) with gain of oncogenic function can regulate cell metabolism. Our recent study revealed a novel transcription-independent mechanism for a gain-...
Stéphane Marcand
Stéphane Marcand
The telomeres of eukaryotes are stable open double-strand ends that coexist with nonhomologous end joining (NHEJ), the repair pathway that directly ligates DNA ends generated by double-strand breaks. Since a single end-joining event between...
Role of the stem cell niche in the pathogenesis of epithelial ovarian cancers [0.03%]
卵巢癌干细胞生态位在上皮性卵巢癌发病机制中的作用
Andrea Flesken-Nikitin,Ashley A Odai-Afotey,Alexander Yu Nikitin
Andrea Flesken-Nikitin
Ovarian cancer is the fifth leading cause of cancer-related deaths among women in the United States. Recent extensive genomic analyses of epithelial ovarian cancer (EOC), particularly the most common and deadly form of high-grade serous ova...
Matthew L Bochman
Matthew L Bochman
Genome integrity is achieved and maintained by the sum of all of the processes in the cell that ensure the faithful duplication and repair of DNA, as well as its genetic transmission from one cell division to the next. As central players in...
Yadi Wu,Binhua P Zhou
Yadi Wu
Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. ...
Lorenzo Galluzzi,Guido Kroemer
Lorenzo Galluzzi
The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition [0.03%]
癌细胞上皮间质转化后的内质网可能是其阿喀琉斯之踵
Yu-Xiong Feng,Ethan S Sokol,Piyush B Gupta
Yu-Xiong Feng
In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial-mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is con...