Rajni Kumari,Saishruti Kohli,Sanjeev Das
Rajni Kumari
p53, the revered savior of genomic integrity, receives signals from diverse stress sensors and strategizes to maintain cellular homeostasis. However, the predominance of p53 overshadows the fact that this herculean task is no one-man show; ...
Maria V Bogachek,James P De Andrade,Ronald J Weigel
Maria V Bogachek
Cancer stem cells (CSCs) represent a subset of tumor cells with tumor-initiating potential. We recently demonstrated that inhibition of the sumoylation pathway cleared the CSC population and repressed the outgrowth of basal breast cancer xe...
Redox-sensitive TP53INP1 SUMOylation as an oxidative stress sensor to activate TP53 [0.03%]
氧敏感的TP53INP1 SUMO化作为氧化应激传感器以激活p53蛋白
Thomas Bonacci,Sylvain Peuget,Philippe Soubeyran et al.
Thomas Bonacci et al.
Oxidative stress-induced sumoylation of TP53INP1 (tumor protein p53-induced nuclear protein 1) is essential to enhance the TP53 response. Sumoylation of TP53INP1 on the K113 residue, which is mediated by protein inhibitor of activated STAT ...
Key regulators of apoptosis execution as biomarker candidates in melanoma [0.03%]
凋亡执行的关键调节因子可作为黑色素瘤生物标志物候选者
Emilie M Charles,Markus Rehm
Emilie M Charles
Resistance to apoptosis is frequently detected in malignant melanoma, a skin cancer with rapidly growing incidence rates. Apoptosis resistance may develop with disease progression and may be associated with the poor responsiveness of metast...
Müge Ogrunc
Müge Ogrunc
Work carried out primarily in the laboratory of Fabrizio d'Adda di Fagagna unveils the mitogenic properties of Ras-induced reactive oxygen species (ROS) and their relationship with the DNA damage response. Combined data from studies of cult...
Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma [0.03%]
功能表征ENPP1揭示了细胞周期进程与胶质母细胞瘤干细胞样表型之间的联系
Josephine Bageritz,Violaine Goidts
Josephine Bageritz
A high-throughput phenotypic screen in glioblastoma stem-like cells (GSCs) identified a novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotid...
VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis [0.03%]
血管内皮生长因子信号、mTOR复合体和内质网：代谢感应在血管生成调控中的作用初探
Evdoxia Karali,Sofia Bellou,Dimitris Stellas et al.
Evdoxia Karali et al.
Vascular endothelial growth factor (VEGF) activates unfolded protein response sensors in the endoplasmic reticulum through phospholipase C gamma (PLCγ)-mediated crosstalk with mammalian target of rapamycin complex 1 (mTORC1). Activation of...
Katherine M Aird,Rugang Zhang
Katherine M Aird
Senescence is defined as a stable cell growth arrest. Oncogene-induced senescence (OIS) occurs in normal primary human cells after activation of an oncogene in the absence of other cooperating oncogenic stimuli. OIS is therefore considered ...
Vineshkumar Thidil Puliyappadamba,Kimmo J Hatanpaa,Sharmistha Chakraborty et al.
Vineshkumar Thidil Puliyappadamba et al.
Activation of NF-κB affects multiple aspects of cancer biology including cell survival and resistance to treatment. Glioblastoma (GBM) is the most common primary malignant tumor of the brain in adults and is resistant to treatment. Recent ...
Chunlai Li,Liuqing Yang,Chunru Lin
Chunlai Li
A large proportion of the control of gene expression in humans is mediated by noncoding elements in the genome. Long noncoding RNAs (lncRNAs) have emerged as a new class of pivotal regulatory components, orchestrating extensive cellular pro...