Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells [0.03%]
细胞周期检查点和DNA复制抑制剂对正常尿路上皮细胞与恶性尿路上皮细胞的不同影响
Mark Meuth
Mark Meuth
S-phase checkpoints are triggered in tumor cells in response to DNA replication stress caused by the tumor microenvironment or oncogenes. A recent report from our laboratory showed that tumor cells and more normal epithelial cells have a ve...
Federica Rossin,Manuela D&#x;Eletto,Maria Grazia Farrace et al.
Federica Rossin et al.
Macroautophagy selectively degrades dysfunctional mitochondria by a process known as mitophagy. The purpose of the study published in Cell Death and Differentiation was to investigate the involvement of transglutaminase 2 (TG2) in the turno...
Lon protease: A key enzyme controlling mitochondrial bioenergetics in cancer [0.03%]
Lon蛋白酶：调控癌症线粒体生物能量的关键酶
Pedro M Quirós,Clea Bárcena,Carlos López-Otín
Pedro M Quirós
We have recently explored the in vivo functional and oncologic relevance of Lon protease (LONP1), an enzyme involved in mitochondrial quality control. We found that LONP1 is an essential protein for life and that it also performs a critical...
Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation [0.03%]
Pumilio和nanos结合RNA的蛋白质可以抵消RB1失活的转录后果
Wayne O Miles,Nicholas J Dyson
Wayne O Miles
The ability of the retinoblastoma protein (RB) tumor suppressor to repress transcription stimulated by the E2 promoter binding factors (E2F) is integral to its biological functions. Our recent report described a conserved feedback mechanism...
Xian-Yang Li,He-Zhou Guo,Jiang Zhu
Xian-Yang Li
Retinoic acid inducible gene-I (RIG-I), named for the observation that its mRNA expression is highly upregulated in the progression of all-trans retinoic acid (ATRA)-induced maturation of acute promyelocytic leukemia (APL) cells, has been w...
PTHrP, its receptor, and protein kinase A activation in osteosarcoma [0.03%]
破骨肉瘤中的PTHrP、其受体及蛋白激酶A的活化
Carl R Walkley,Mannu K Walia,Patricia W Ho et al.
Carl R Walkley et al.
In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in ...
Alvaro Ingles-Prieto,Eva Reichhart,Karin Schelch et al.
Alvaro Ingles-Prieto et al.
As light-based control of fundamental signaling pathways is becoming a reality, the field of optogenetics is rapidly moving beyond neuroscience. We have recently developed receptor tyrosine kinases that are activated by light and control ce...
Ann-Marie Baker,Trevor A Graham
Ann-Marie Baker
Stem cell and crypt dynamics in the human gut have been remarkably poorly characterized. We used random somatic mutations to trace stem cell lineages in the human intestine and coupled these data with mathematical modeling to infer the in v...
Awakening the Hippo co-activator YAP1, a mercurial cancer gene, in hematologic cancers [0.03%]
唤醒 hippo 信号通路共激活因子 yap1 在血液系统肿瘤中的作用机制研究
Francesca Cottini,Kenneth C Anderson,Giovanni Tonon
Francesca Cottini
Unrestrained oncogene activity triggers DNA damage. Cancer cells exploit various stratagems to deal with this potentially lethal event. We found that hematologic cancer cells inactivate the Hippo co-activator Yes-associated protein 1 (YAP1)...
ZNF423: Transcriptional modulation in development and cancer [0.03%]
锌指蛋白423(ZNF423)在发育和癌症中的转录调控功能研究
Lena Harder,Ann-Christin Puller,Martin A Horstmann
Lena Harder
Krüppel-like zinc finger proteins are versatile players in biology that have been implicated in mammalian development and disease. Among these proteins, ZNF423 and its mouse ortholog Zfp423 were initially implicated in midline patterning o...