Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene [0.03%]
视网膜母细胞瘤肿瘤抑制基因的条件性单倍体不足
Charles A Ishak,Frederick A Dick
Charles A Ishak
Recent work demonstrates that retention of a single functional retinoblastoma susceptibility (RB1) allele is insufficient to maintain genome stability. Haploinsufficiency of RB1 accelerates cancer pathogenesis in concert with inactivation o...
Ann Zeuner
Ann Zeuner
Quiescence represents a survival strategy adopted by cancer stem cells (CSCs) to resist harsh environmental conditions and cytotoxic insults. Recent studies show that quiescent CSCs are found in a low metabolic state in which they are exqui...
Animal model studies indicate a candidate biomarker for sorafenib treatment of hepatocellular carcinoma [0.03%]
动物模型研究发现肝细胞癌索拉非尼治疗候选生物标志物
Elad Horwitz,Ilan Stein,Yinon Ben-Neriah et al.
Elad Horwitz et al.
In contrast to common genomic amplifications that support cancer cell growth by rewiring intracellular signaling, VEGFA amplification drives tumor cell proliferation via the tumor microenvironment. VEGFA amplification is present in a subset...
Role of the double-strand break repair pathway in the maintenance of genomic stability [0.03%]
双链断裂修复通路在维持基因组稳定性中的作用
Tangui Le Guen,Sandrine Ragu,Josée Guirouilh-Barbat et al.
Tangui Le Guen et al.
DNA double-strand breaks (DSBs) are highly lethal lesions that jeopardize genome integrity. However, DSBs are also used to generate diversity during the physiological processes of meiosis or establishment of the immune repertoire. Therefore...
XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle [0.03%]
X蛋白作为炎症性细胞死亡调节因子：肿瘤坏死因子和RIP3的角度
Monica Yabal,Philipp J Jost
Monica Yabal
There is currently immense interest in understanding the biological consequences of aberrant necroptosis. The recently uncovered role for X-linked inhibitor of apoptosis protein (XIAP) in blocking tumor necrosis factor-dependent necroptosis...
Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival [0.03%]
甜与癌症细胞代谢和存活间的联系：O-GlcNA酰化链接癌细胞代谢和生存
Christina M Ferrer,Mauricio J Reginato
Christina M Ferrer
Increased O-GlcNAcylation is emerging as a general characteristic of cancer cells that is critical for multiple oncogenic phenotypes. Recently, we demonstrated that elevated O-GlcNAcylation contributes to the metabolic shift seen in cancer ...
Yulin Li,Stephanie C Casey,Peter S Choi et al.
Yulin Li et al.
MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17-92 clust...
Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells [0.03%]
p62在急性髓系白血病细胞粒状分化过程中的促生存作用
Evelyne Ségal-Bendirdjian,Mario P Tschan,Josy Reiffers et al.
Evelyne Ségal-Bendirdjian et al.
p62 regulates key signaling pathways including those that control cell death and autophagy. Recently, we reported that p62 is upregulated during all-trans retinoic acid (ATRA)-induced terminal differentiation of acute myeloid leukemia (AML)...
The programmed cell death GLuc PCA library - a powerful tool for pathway discovery and drug screening [0.03%]
程序性细胞死亡GLuc PCA库——一条强大的通路发现和药物筛选途径
Yuval Gilad,Adi Kimchi
Yuval Gilad
A programmed cell death library based on the Gaussia luciferase protein-fragment complementation assay (GLuc PCA) enables detection of protein-protein interactions (PPI) within the cell death network and quantitative assessments of these in...
Reinhard Dechant,Matthias Peter
Reinhard Dechant
Although target of rapamycin (TOR) kinase and Ras are central regulators of cell growth in yeast and mammals, the molecular mechanisms underlying their regulation by nutrients are still poorly understood. Interestingly, recent studies ident...