Claudio Raimondi,Alessandro Fantin,Christiana Ruhrberg
Claudio Raimondi
We recently reported that neuropilin 1 (NRP1) drives angiogenesis by promoting extracellular matrix signaling in endothelial cells via ABL1 kinase. Imatinib targets this pathway in pathological angiogenesis and may provide a novel opportuni...
Hiba Ahmad Zahreddine,Biljana Culjkovic-Kraljacic,Katherine Lb Borden
Hiba Ahmad Zahreddine
Chemoresistance remains a major impediment in cancer therapy. Although major progress has been made in understanding the mechanisms underlying resistance in cancer, there is still more to learn. Our studies provide evidence that Gli1 drives...
Susana A Godinho
Susana A Godinho
Despite being a common feature of human cancer, the role of supernumerary centrosomes in tumourigenesis is still poorly understood. We have recently described a novel role for centrosome amplification in promoting cell invasion that could i...
Petrus R de Jong,Samuel Bertin,Eyal Raz
Petrus R de Jong
TRP channels are associated with the development and progression of cancer but their precise molecular roles in these processes are unclear. Recently, we showed that the transient receptor potential cation channel, subfamily V, member 1 (TR...
Targeting the hallmarks of cancer with therapy-induced endoplasmic reticulum (ER) stress [0.03%]
利用诱导内质网(ER)应激的疗法针对癌症标志物
Abhishek D Garg,Hannelore Maes,Alexander R van Vliet et al.
Abhishek D Garg et al.
The endoplasmic reticulum (ER) is at the center of a number of vital cellular processes such as cell growth, death, and differentiation, crosstalk with immune or stromal cells, and maintenance of proteostasis or homeostasis, and ER function...
UCP2 induces metabolic reprogramming to inhibit proliferation of cancer cells [0.03%]
UCP2诱导代谢重编程以抑制癌细胞增殖
Pauline Esteves,Claire Pecqueur,Marie-Clotilde Alves-Guerra
Pauline Esteves
Invalidation of uncoupling protein 2 (Ucp2) increases glucose utilization and proliferation in normal cells. We recently reported that cancer cells that overexpress UCP2 become less tumorigenic while switching their metabolism from glycolys...
YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations [0.03%]
YAP抑制作用可阻断由GNAQ或GNA11突变驱动的脉络膜黑色素细胞色素生成
Vera Lyubasyuk,Hong Ouyang,Fa-Xing Yu et al.
Vera Lyubasyuk et al.
Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein...
The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression [0.03%]
剪接调控因子在肿瘤发生和发展过程中替代剪接去调控中的作用
Asaf Shilo,Zahava Siegfried,Rotem Karni
Asaf Shilo
In past decades, cancer research has focused on genetic alterations that are detected in malignant tissues and contribute to the initiation and progression of cancer. These changes include mutations, copy number variations, and translocatio...
Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease [0.03%]
停止放松：DNA损伤诱导的染色质压缩可能如何影响表观遗传完整性和疾病
Philipp Oberdoerffer
Philipp Oberdoerffer
DNA damage is widely recognized for its potential to impair epigenetic integrity. Epigenetic defects are closely associated with a variety of diseases. We have recently uncovered DNA double-strand break-induced chromatin condensation as a c...
Antoaneta Belcheva,Alberto Martin
Antoaneta Belcheva
Understanding the complex pathophysiology of colorectal cancer and the interaction between host genetics, the gut microbiome, and diet has attracted significant attention in the last few years. The discovery that gut microbial metabolites m...