Muhannad Abu-Remaileh,Victoria L Seewaldt,Rami I Aqeilan
Muhannad Abu-Remaileh
Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for...
Gabriel Ichim,Stephen Wg Tait
Gabriel Ichim
Apoptosis and necroptosis are 2 major, yet distinct, forms of regulated cell death. Whereas apoptosis requires caspase protease function, necroptosis requires activation of the receptor interacting protein kinases 1 (RIPK1) and RIPK3. Follo...
Abhishek A Chakraborty,William P Tansey
Abhishek A Chakraborty
The role of changes in the c-MYC coding sequence in cancer is controversial. Overexpression of wild-type protein is sufficient to drive tumorigenesis, yet point mutations in c-MYC are common in Burkitt's lymphoma. Our discovery that dispara...
Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells "it's time to die" [0.03%]
溶酶体靶向的REV-ERB拮抗作用：昼夜节律和自噬之间的代谢联系可能提示癌细胞“是时候死了”
Benedetto Grimaldi
Benedetto Grimaldi
The discovery that inhibition of a circadian regulator enhances autophagy-dependent cancer cell death reveals potential avenues for the development of new multifunctional anticancer agents. Further studies may elucidate novel crosstalk betw...
Joyce V Lee,Supriya Shah,Alessandro Carrer et al.
Joyce V Lee et al.
Histone acetylation is sensitive to the availability of acetyl-CoA. However, the extent to which metabolic alterations in cancer cells impact tumor histone acetylation has been unclear. Here, we discuss our recent findings that oncogenic AK...
Ailine Stolz,Norman Ertych,Holger Bastians
Ailine Stolz
Although chromosomal instability (CIN) is a recognized hallmark of cancer the underlying mechanisms and consequences are largely unknown. However, it is accepted that lagging chromosomes represent a major prerequisite for chromosome missegr...
Zhangang Xiao,Yangchao Chen
Zhangang Xiao
miR-34a functions as a tumor suppressor in many cancers. In a recent issue of Cancer Research, we describe a small molecule, Rubone, with strong anticancer activity. Rubone selectively restored miR-34a expression in hepatocellular carcinoma...
Alternative end joining, clonal evolution, and escape from a telomere-driven crisis [0.03%]
备选末端连接、克隆演化和逃避端粒驱动的危机
Eric A Hendrickson,Duncan M Baird
Eric A Hendrickson
Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by t...
Two roads to death - Bax targets mitochondria by distinct routes before or during apoptotic cell death [0.03%]
两条通向死亡的道路-Bax通过不同的途径在凋亡细胞死亡之前或期间靶向线粒体
Grant Dewson
Grant Dewson
Recent studies have revolutionized our understanding of how the crucial apoptosis effectors Bax and Bak target mitochondria to kill cells. We recently reported that an important determinant of the localization, oligomerization, and apoptoti...
Tiziana Lischetti,Jakob Nilsson
Tiziana Lischetti
Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle. The spindle assembly checkpoint (SAC) protects again...