Hydrogen sulfide operates as a glioblastoma suppressor and is lost under high fat diet [0.03%]
硫化氢作为胶质母细胞瘤抑制因子，并在高脂饮食下失去作用
Daniel J Silver,Justin D Lathia,Christopher Hine
Daniel J Silver
Glioblastoma (GBM) is one of the deadliest and aggressive forms of brain cancer. Environmental and intrinsic factors such as Western Diet and advanced age can function as powerful accelerants to the progression of GBM. Recently, we discover...
A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer [0.03%]
乳腺癌中连接PI3Kα和WNT/β-连环蛋白信号的晚期内体信号中心
Samuel J Rodgers,Sabryn A Hamila,Christina A Mitchell et al.
Samuel J Rodgers et al.
AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly ...
Predicting survival of cancer patients by chromosomal copy number heterogeneity [0.03%]
通过染色体拷贝数异质性预测癌症患者生存率
Tom Van Den Bosch,Erik van Dijk,Louis Vermeulen et al.
Tom Van Den Bosch et al.
We recently introduced a method to derive intra-tumor heterogeneity (ITH) from a single copy number measurement. This method stratifies patients for survival and could potentially help to identify low and high-risk patients with clinical re...
AMBRA1 and FAK1: crosstalking for improved targeted therapy in melanoma [0.03%]
AMBRA1和FAK1在黑色素瘤靶向治疗中的相互交流作用
Luca Di Leo,Daniela De Zio
Luca Di Leo
Through genetically engineered mouse models of melanoma, we identified Autophagy/beclin 1 regulator 1 (Ambra1) as novel tumor-suppressor in melanoma. In these settings, loss of Ambra1 associated with the hyperactivation of focal adhesion ki...
Mónica Vara-Pérez,Patrizia Agostinis
Mónica Vara-Pérez
Melanoma cells exploit mitophagy and hypoxia signaling to promote their growth. In a recent study, we found that loss of B-cell lymphoma 2 (BCL-2)/adenovirus E1B 19kDa protein-interacting protein 3 (BNIP3) curbed Hypoxia Inducible Factor 1 ...
Francesco Cecconi,Francesca Nazio
Francesco Cecconi
TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autop...
Akshay Narkar,Blake A Johnson,Rong Li
Akshay Narkar
TP53-dependent cell cycle arrest has been proposed to limit the proliferation of aneuploid cells. We investigated the cellular response to aneuploidy in cell lines and organoid cultures and found that TP53 (also known as p53) is not activat...
A direct role of RNA polymerase III and RNA in DNA homologous recombination [0.03%]
RNA聚合酶III和RNA在DNA同源重组中的直接作用
Sijie Liu,Daochun Kong
Sijie Liu
End resection excises several thousand bases from the 5'-ended strand during DNA double-strand break repair, creating 3'-end single-stranded DNA overhangs. This overhang requires strict protection from DNA2 or other nucleases digestion. A r...
Non-neuroendocrine differentiation generates a ferroptosis-prone lipidome in small cell lung cancer (SCLC) [0.03%]
非神经内分泌分化在小细胞肺癌(SCLC)中产生了易发生铁死亡的脂质组
Christina M Bebber,Silvia von Karstedt
Christina M Bebber
Our recent study revealed that non-neuroendocrine small cell lung cancer (SCLC) is sensitive to the induction of ferroptosis due to upregulation of ether lipid synthesis. While neuroendocrine SCLC is ferroptosis resistant, it acquires addic...
Cancer-associated keratinocytes: new members of the microenvironment in head and neck cancer [0.03%]
与癌症相关的角质形成细胞：头颈部癌症微环境中新的成员
Erika B Danella,Marcell Costa De Medeiros,Nisha J D&#x;Silva
Erika B Danella
The tumor microenvironment is a complex ecosystem of malignant and nonmalignant cells and extracellular proteins that work together to enhance tumor progression. We identified a mechanism in which adjacent nonmalignant epithelium enhances i...