Ana Ortega-Molina,Alejo Efeyan
Ana Ortega-Molina
The identification of the Rag GTPases initiated the deciphering of the molecular puzzle of nutrient signaling to the mechanistic target of rapamycin (mTOR), and spurred interest in targeting this pathway to combat human disease. Recent mous...
SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix [0.03%]
SGK1调节的代谢反应对脱离细胞外基质的细胞存活至关重要
Jordan A Cockfield,Zachary T Schafer
Jordan A Cockfield
Cells that lack attachment to the extracellular matrix (ECM) experience metabolic defects that can lead to caspase-independent cell death. Recently, we discovered that serum and glucocorticoid kinase-1 (SGK1) plays a critical role in the re...
A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate [0.03%]
从发现到验证癌症患者的有效性的一段科学旅程：HAMLET和alpha1-油酸
James C S Ho,Ines Ambite,K H Mok et al.
James C S Ho et al.
The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and re...
Vincent Chen,Chu Bo,Wei Gu
Vincent Chen
The calcium-independent phospholipase iPLA2β has been identified as a transcriptional target of the tumor suppressor TP53 (or p53). Unlike GPX4 (glutathione peroxidase 4), iPLA2β is not required for normal homeostasis but critical for fer...
The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential [0.03%]
SWI/SNF 复合体，转录-复制冲突与癌症：一种具有较高治疗潜力的联系
Aleix Bayona-Feliu,Andrés Aguilera
Aleix Bayona-Feliu
Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-medi...
Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1 [0.03%]
解开分离酶通过Securin和CDK1-CCNB1抑制人类分离酶的方式
Pierre Raia,Jun Yu,Andreas Boland
Pierre Raia
Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids. We recently reported structures of human separase bound to its inhib...
Hydrogen sulfide operates as a glioblastoma suppressor and is lost under high fat diet [0.03%]
硫化氢作为胶质母细胞瘤抑制因子，并在高脂饮食下失去作用
Daniel J Silver,Justin D Lathia,Christopher Hine
Daniel J Silver
Glioblastoma (GBM) is one of the deadliest and aggressive forms of brain cancer. Environmental and intrinsic factors such as Western Diet and advanced age can function as powerful accelerants to the progression of GBM. Recently, we discover...
A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer [0.03%]
乳腺癌中连接PI3Kα和WNT/β-连环蛋白信号的晚期内体信号中心
Samuel J Rodgers,Sabryn A Hamila,Christina A Mitchell et al.
Samuel J Rodgers et al.
AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly ...
Predicting survival of cancer patients by chromosomal copy number heterogeneity [0.03%]
通过染色体拷贝数异质性预测癌症患者生存率
Tom Van Den Bosch,Erik van Dijk,Louis Vermeulen et al.
Tom Van Den Bosch et al.
We recently introduced a method to derive intra-tumor heterogeneity (ITH) from a single copy number measurement. This method stratifies patients for survival and could potentially help to identify low and high-risk patients with clinical re...
AMBRA1 and FAK1: crosstalking for improved targeted therapy in melanoma [0.03%]
AMBRA1和FAK1在黑色素瘤靶向治疗中的相互交流作用
Luca Di Leo,Daniela De Zio
Luca Di Leo
Through genetically engineered mouse models of melanoma, we identified Autophagy/beclin 1 regulator 1 (Ambra1) as novel tumor-suppressor in melanoma. In these settings, loss of Ambra1 associated with the hyperactivation of focal adhesion ki...