Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype [0.03%]
脂肪 Stromal细胞促进结肠癌细胞向间充质表型转化
Simone Di Franco,Giorgio Stassi
Simone Di Franco
Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal tra...
KMT2D deficiency confers a therapeutic vulnerability to glycolytic and IGFR inhibitors in melanoma [0.03%]
KMT2D缺乏在黑色素瘤中对糖酵解和IGFR抑制剂产生了治疗上的脆弱性
Navya Murugesan,Mayinuer Maitituoheti
Navya Murugesan
We reported that histone H3 lysine (K) 4 methyltransferase, KMT2D, serves as a potent tumor-suppressor in melanoma, which was identified via in vivo epigenome-focused RNA interference (RNAi) screen. KMT2D-deficient tumors show substantial r...
Christina G Towers
Christina G Towers
Autophagy is a central recycling process, and it plays a complex role in cancer. We discovered that when autophagy is blocked, cancer cells compensate by increasing mitochondrial-derived vesicles. However, there are many unanswered question...
Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects [0.03%]
癌症简化：由相反的YAP / TEAD效应分层的二元泛癌超类
Joel D Pearson,Rod Bremner
Joel D Pearson
The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expressio...
Ana Ortega-Molina,Alejo Efeyan
Ana Ortega-Molina
The identification of the Rag GTPases initiated the deciphering of the molecular puzzle of nutrient signaling to the mechanistic target of rapamycin (mTOR), and spurred interest in targeting this pathway to combat human disease. Recent mous...
SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix [0.03%]
SGK1调节的代谢反应对脱离细胞外基质的细胞存活至关重要
Jordan A Cockfield,Zachary T Schafer
Jordan A Cockfield
Cells that lack attachment to the extracellular matrix (ECM) experience metabolic defects that can lead to caspase-independent cell death. Recently, we discovered that serum and glucocorticoid kinase-1 (SGK1) plays a critical role in the re...
A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate [0.03%]
从发现到验证癌症患者的有效性的一段科学旅程：HAMLET和alpha1-油酸
James C S Ho,Ines Ambite,K H Mok et al.
James C S Ho et al.
The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and re...
Vincent Chen,Chu Bo,Wei Gu
Vincent Chen
The calcium-independent phospholipase iPLA2β has been identified as a transcriptional target of the tumor suppressor TP53 (or p53). Unlike GPX4 (glutathione peroxidase 4), iPLA2β is not required for normal homeostasis but critical for fer...
The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential [0.03%]
SWI/SNF 复合体，转录-复制冲突与癌症：一种具有较高治疗潜力的联系
Aleix Bayona-Feliu,Andrés Aguilera
Aleix Bayona-Feliu
Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-medi...
Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1 [0.03%]
解开分离酶通过Securin和CDK1-CCNB1抑制人类分离酶的方式
Pierre Raia,Jun Yu,Andreas Boland
Pierre Raia
Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids. We recently reported structures of human separase bound to its inhib...