Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia [0.03%]
FOXC1错义表达募集RUNX1-HDAC1-TLE3共抑制复合物干扰急性髓系白血病分化
Fabrizio Simeoni,Tim Cp Somervaille
Fabrizio Simeoni
Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabili...
Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade [0.03%]
免疫原性细胞应激和损伤与免疫原性细胞死亡：对利用免疫检查点阻断改善癌症治疗的启示
Ganapathy Sriram,Tiffany R Emmons,Lauren E Milling et al.
Ganapathy Sriram et al.
Inducing immunogenic tumor cell death to stimulate the response to immune checkpoint blockade has not yet been effectively translated into clinical practice. We recently discovered that stressed/injured but still viable tumor cells are crit...
RAD51 wrestles with SUMO [0.03%]
SUMO与RAD51博弈
Younghoon Kee,Jung-Hee Lee,Ho Jin You
Younghoon Kee
RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylati...
Mercedes Blanco-Benítez,Ana Calderón-Fernández,Saray Canales-Cortés et al.
Mercedes Blanco-Benítez et al.
Phenolic compounds derived from olive oil have beneficial health properties against cancer, neurodegenerative, and metabolic diseases. Therefore, there are discrepancies in their impact on mitochondrial function that result in changes in ox...
Priyanka Bansal,Christoph F Kurat
Priyanka Bansal
We have recently revealed the existence of a cell cycle-regulated chromatin segregase, Yta7 (Yeast Tat-binding Analog 7), involved in chromosome replication. Phosphorylation of Yta7 by S-CDK (S-phase Cyclin-Dependent Kinase) regulates its f...
Chandrani Mukhopadhyay,Pengbo Zhou
Chandrani Mukhopadhyay
Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3SPOP), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor progn...
Christos P Zampetidis,Argyris Papantonis,Vassilis G Gorgoulis
Christos P Zampetidis
Although senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. Consequently, senescence appears as an imperfect barrier to impede cancer progression, constituting a step prior to dis...
Aziz M Rangwala,Benedict-Tilman Berger,Matthew B Robers et al.
Aziz M Rangwala et al.
Imatinib, a selective inhibitor of the breakpoint cluster region (BCR)-ABL kinase, is the poster child for targeted cancer therapeutics. However, its efficacy is limited by resistance mutations. Using a quantitative bioluminescence resonanc...
Barrett's esophagus stages: their correlation with SBS17-associated DNA mutations and the identification of histological marker genes [0.03%]
巴雷特食管的病理分期及其与SBS17相关DNA突变的相关性及组织标记基因的鉴定
Georg A Busslinger
Georg A Busslinger
We have recently reported a correlation between the accumulation of specific T > C and T > G mutations and the chromosomal instability in cells of Barrett's esophagus (BE), which represents a premalignant condition of esophageal adenocarcin...
Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma [0.03%]
脂质代谢的重塑可作为治疗激进型结直肠癌的有效手段
Daria Capece,Guido Franzoso
Daria Capece
Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma ...