Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment [0.03%]
肿瘤抑制途径塑造EGFR驱动的肺肿瘤进展和治疗反应
Giorgia Foggetti,Chuan Li,Hongchen Cai et al.
Giorgia Foggetti et al.
In vivo modeling combined with CRISPR/Cas9-mediated somatic genome editing has contributed to elucidating the functional importance of specific genetic alterations in human tumors. Our recent work uncovered tumor suppressor pathways that af...
Bi Shi,Wei Li,Hao Jiang
Bi Shi
Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear. We discovered that lysine demethylase 6A (KDM6A, also known as UTX) suppresses cancer by...
Aiman Sabaawy,Saman Zeeshan
Aiman Sabaawy
JAK/STAT signaling is a central hub in cancer development, progression, immunosurveillance and response to immunotherapy. We discuss recent advances in the role of the JAK/STAT pathway in immunotherapies. We stress the importance of fully u...
ERBB3 as a therapeutic target in glioblastoma: overexpression can make the difference [0.03%]
ERBB3作为胶质母细胞瘤中的治疗靶点：过表达则会产生差异
Francesca De Bacco,Carla Boccaccio
Francesca De Bacco
By exploiting an integrated experimental platform based on patient-derived cancer stem cells, we identified a glioblastoma subset characterized by inheritable Erb-B2 Receptor Tyrosine Kinase 3 (ERBB3) overexpression, metabolic dependency on...
How multi-component cascades operate in cells: lessons from the ubiquitin system-containing liquid-separated condensates [0.03%]
多组分级联在细胞中如何运作：来自含有液相分离 Condensates 的泛素系统中的启示
Afu Fu,Ido Livneh,Aaron Ciechanover et al.
Afu Fu et al.
Membraneless condensates have recently caught the attention of biologists as hubs for cellular components required for catalysis of basic processes. Whether they are real has become the center of heated discussion where the main issues are ...
Chromatin state profiling reveals PRC2 inhibition as a therapeutic target in NRAS-mutant melanoma [0.03%]
染色质状态分析显示PRC2抑制是NRAS突变黑色素瘤的治疗靶点
Christopher J Terranova
Christopher J Terranova
Recently, we have generated 284 epigenomic maps in melanoma. Using chromatin state profiling we identify an association of NRAS-mutants with bivalent Histone H3 lysine 27 trimethylation (H3K27me3) and broad H3K4me3 domains. Reprogramming of...
Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype [0.03%]
脂肪 Stromal细胞促进结肠癌细胞向间充质表型转化
Simone Di Franco,Giorgio Stassi
Simone Di Franco
Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal tra...
KMT2D deficiency confers a therapeutic vulnerability to glycolytic and IGFR inhibitors in melanoma [0.03%]
KMT2D缺乏在黑色素瘤中对糖酵解和IGFR抑制剂产生了治疗上的脆弱性
Navya Murugesan,Mayinuer Maitituoheti
Navya Murugesan
We reported that histone H3 lysine (K) 4 methyltransferase, KMT2D, serves as a potent tumor-suppressor in melanoma, which was identified via in vivo epigenome-focused RNA interference (RNAi) screen. KMT2D-deficient tumors show substantial r...
Christina G Towers
Christina G Towers
Autophagy is a central recycling process, and it plays a complex role in cancer. We discovered that when autophagy is blocked, cancer cells compensate by increasing mitochondrial-derived vesicles. However, there are many unanswered question...
Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects [0.03%]
癌症简化：由相反的YAP / TEAD效应分层的二元泛癌超类
Joel D Pearson,Rod Bremner
Joel D Pearson
The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expressio...