Christos P Zampetidis,Argyris Papantonis,Vassilis G Gorgoulis
Christos P Zampetidis
Although senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. Consequently, senescence appears as an imperfect barrier to impede cancer progression, constituting a step prior to dis...
Aziz M Rangwala,Benedict-Tilman Berger,Matthew B Robers et al.
Aziz M Rangwala et al.
Imatinib, a selective inhibitor of the breakpoint cluster region (BCR)-ABL kinase, is the poster child for targeted cancer therapeutics. However, its efficacy is limited by resistance mutations. Using a quantitative bioluminescence resonanc...
Barrett's esophagus stages: their correlation with SBS17-associated DNA mutations and the identification of histological marker genes [0.03%]
巴雷特食管的病理分期及其与SBS17相关DNA突变的相关性及组织标记基因的鉴定
Georg A Busslinger
Georg A Busslinger
We have recently reported a correlation between the accumulation of specific T > C and T > G mutations and the chromosomal instability in cells of Barrett's esophagus (BE), which represents a premalignant condition of esophageal adenocarcin...
Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma [0.03%]
脂质代谢的重塑可作为治疗激进型结直肠癌的有效手段
Daria Capece,Guido Franzoso
Daria Capece
Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma ...
Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment [0.03%]
肿瘤抑制途径塑造EGFR驱动的肺肿瘤进展和治疗反应
Giorgia Foggetti,Chuan Li,Hongchen Cai et al.
Giorgia Foggetti et al.
In vivo modeling combined with CRISPR/Cas9-mediated somatic genome editing has contributed to elucidating the functional importance of specific genetic alterations in human tumors. Our recent work uncovered tumor suppressor pathways that af...
Bi Shi,Wei Li,Hao Jiang
Bi Shi
Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear. We discovered that lysine demethylase 6A (KDM6A, also known as UTX) suppresses cancer by...
Aiman Sabaawy,Saman Zeeshan
Aiman Sabaawy
JAK/STAT signaling is a central hub in cancer development, progression, immunosurveillance and response to immunotherapy. We discuss recent advances in the role of the JAK/STAT pathway in immunotherapies. We stress the importance of fully u...
ERBB3 as a therapeutic target in glioblastoma: overexpression can make the difference [0.03%]
ERBB3作为胶质母细胞瘤中的治疗靶点：过表达则会产生差异
Francesca De Bacco,Carla Boccaccio
Francesca De Bacco
By exploiting an integrated experimental platform based on patient-derived cancer stem cells, we identified a glioblastoma subset characterized by inheritable Erb-B2 Receptor Tyrosine Kinase 3 (ERBB3) overexpression, metabolic dependency on...
How multi-component cascades operate in cells: lessons from the ubiquitin system-containing liquid-separated condensates [0.03%]
多组分级联在细胞中如何运作：来自含有液相分离 Condensates 的泛素系统中的启示
Afu Fu,Ido Livneh,Aaron Ciechanover et al.
Afu Fu et al.
Membraneless condensates have recently caught the attention of biologists as hubs for cellular components required for catalysis of basic processes. Whether they are real has become the center of heated discussion where the main issues are ...
Chromatin state profiling reveals PRC2 inhibition as a therapeutic target in NRAS-mutant melanoma [0.03%]
染色质状态分析显示PRC2抑制是NRAS突变黑色素瘤的治疗靶点
Christopher J Terranova
Christopher J Terranova
Recently, we have generated 284 epigenomic maps in melanoma. Using chromatin state profiling we identify an association of NRAS-mutants with bivalent Histone H3 lysine 27 trimethylation (H3K27me3) and broad H3K4me3 domains. Reprogramming of...