Sunghoon Kim,Andrew Wolfe,Sung Eun Kim
Sunghoon Kim
Understanding the mechanisms governing metabolic reprogramming that underlie potential vulnerabilities in cancer cells is key to developing novel therapeutic strategies. The catalytic enzyme UDP-glucose pyrophosphorylase 2 (UGP2) drives the...
Caiyun Liu,Xinjian Li
Caiyun Liu
How cancer cells absorb enough glucose to support their rapid growth is poorly understood. We have recently demonstrated that palmitoyl transferase DHHC9 palmitoylates glucose transporter GLUT1 at Cys207 to maintain GLUT1 plasma membrane lo...
ZNF768: controlling cellular senescence and proliferation with ten fingers [0.03%]
锌指基因ZNF768用十个手指调控细胞衰老和增殖
Romain Villot,Audrey Poirier,Romain Devillers et al.
Romain Villot et al.
We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle progression and triggers cellul...
Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα [0.03%]
细胞死亡受抑：线粒体和IκBα的意外联系
Evangelos Pazarentzos
Evangelos Pazarentzos
IκΒα (the protein product of NFKBIA gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB. Our findings indicate that IκΒα also exerts a strong anti-apopto...
A therapeutic window for preventive therapy in NF1-associated optic pathway glioma [0.03%]
NF1相关视路胶质瘤预防性治疗的治疗窗口期研究
Yuan Zhu,Wang Zheng,Emmanuelle S Jecrois et al.
Yuan Zhu et al.
Pediatric low-grade gliomas (pLGGs) are almost universally driven by abnormal activation of RAS-mediated MEK-ERK/MAPK signaling pathway. pLGGs predominantly occur in children, suggesting that they originate in an ERK-dependent neural stem/p...
Aurora A and Mcl-1: new potential treatment targets in antiestrogen-resistant breast cancer [0.03%]
乳腺癌中抗雌激素耐药的新治疗靶点Aurora A和Mcl-1
Christina W Yde
Christina W Yde
Antiestrogen resistance is a major clinical limitation in treatment of breast cancer. We have recently reported that Aurora A and Mcl-1 (myeloid cell leukemia 1) are potential novel treatment targets in antiestrogen-resistant breast cancer ...
Anja Bufe,Sergio P Acebrón
Anja Bufe
WNT signaling regulates cell cycle progression and fate determination through β-catenin dependent transcription, and its misregulation is often associated with tumorigenesis. Our recent work demonstrated that basal WNT activity is also req...
A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops) [0.03%]
由非计划性RNA-DNA杂交体(R-loop)介导的针对氧化应激的线粒体反应
Xavier Renaudin,Ashok R Venkitaraman
Xavier Renaudin
How oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (...
Marta Llorens-Agost,Michael Ensminger,Hang Phuong Le et al.
Marta Llorens-Agost et al.
How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appear...
Bastian Stark,Gregory M K Poon,John J Wyrick
Bastian Stark
Somatic mutations in skin cancers are highly enriched at binding sites for CCCTC-binding factor (CTCF). We have discovered that CTCF binding alters the DNA structure to render it more susceptible to UV damage. Elevated UV damage formation a...