Anja Bufe,Sergio P Acebrón
Anja Bufe
WNT signaling regulates cell cycle progression and fate determination through β-catenin dependent transcription, and its misregulation is often associated with tumorigenesis. Our recent work demonstrated that basal WNT activity is also req...
A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops) [0.03%]
由非计划性RNA-DNA杂交体(R-loop)介导的针对氧化应激的线粒体反应
Xavier Renaudin,Ashok R Venkitaraman
Xavier Renaudin
How oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (...
Marta Llorens-Agost,Michael Ensminger,Hang Phuong Le et al.
Marta Llorens-Agost et al.
How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appear...
Bastian Stark,Gregory M K Poon,John J Wyrick
Bastian Stark
Somatic mutations in skin cancers are highly enriched at binding sites for CCCTC-binding factor (CTCF). We have discovered that CTCF binding alters the DNA structure to render it more susceptible to UV damage. Elevated UV damage formation a...
Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia [0.03%]
FOXC1错义表达募集RUNX1-HDAC1-TLE3共抑制复合物干扰急性髓系白血病分化
Fabrizio Simeoni,Tim Cp Somervaille
Fabrizio Simeoni
Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabili...
Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade [0.03%]
免疫原性细胞应激和损伤与免疫原性细胞死亡：对利用免疫检查点阻断改善癌症治疗的启示
Ganapathy Sriram,Tiffany R Emmons,Lauren E Milling et al.
Ganapathy Sriram et al.
Inducing immunogenic tumor cell death to stimulate the response to immune checkpoint blockade has not yet been effectively translated into clinical practice. We recently discovered that stressed/injured but still viable tumor cells are crit...
RAD51 wrestles with SUMO [0.03%]
SUMO与RAD51博弈
Younghoon Kee,Jung-Hee Lee,Ho Jin You
Younghoon Kee
RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylati...
Mercedes Blanco-Benítez,Ana Calderón-Fernández,Saray Canales-Cortés et al.
Mercedes Blanco-Benítez et al.
Phenolic compounds derived from olive oil have beneficial health properties against cancer, neurodegenerative, and metabolic diseases. Therefore, there are discrepancies in their impact on mitochondrial function that result in changes in ox...
Priyanka Bansal,Christoph F Kurat
Priyanka Bansal
We have recently revealed the existence of a cell cycle-regulated chromatin segregase, Yta7 (Yeast Tat-binding Analog 7), involved in chromosome replication. Phosphorylation of Yta7 by S-CDK (S-phase Cyclin-Dependent Kinase) regulates its f...
Chandrani Mukhopadhyay,Pengbo Zhou
Chandrani Mukhopadhyay
Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3SPOP), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor progn...